Leishmaniasis in Portugal: enzyme polymorphism of <i>Leishmania infantum</i> based on the identification of 213 strains

Campino, Lenea; Pratlong, Francine; Abranches, P.; Rioux, J. A.; Santos‐Gomes, Gabriela; Alves-Pires, C.; Cortes, Sofia; Ramada, João; Cristóvão, José Manuel; Afonso, Maria Odete; Dedet, Jean-Pierre

doi:10.1111/j.1365-3156.2006.01728.x

Cited by 52 publications

(43 citation statements)

References 26 publications

(21 reference statements)

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“…The data presented are based on a compilation of several papers, mainly three papers published in a 2003 special issue of Annals of Tropical Medicine and Parasitology, namely, those by Pratlong et al (195) for southern France, Chicharro et al (59) for Spain, and Gramiccia (108) for Italy, and a recent paper by Campino et al (54) for Portugal.…”

Section: Microbiologymentioning

confidence: 99%

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

et al. 2008

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SUMMARY To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of coinfection were identified, of which 90% were from Spain, Italy, France, and Portugal. However, these figures are misleading because they do not account for the large proportion of cases in many African and Asian countries that are missed due to a lack of diagnostic facilities and poor reporting systems. Most cases of coinfection in the Americas are reported in Brazil, where the incidence of leishmaniasis has spread in recent years due to overlap with major areas of HIV transmission. In some areas of Africa, the number of coinfection cases has increased dramatically due to social phenomena such as mass migration and wars. In northwest Ethiopia, up to 30% of all visceral leishmaniasis patients are also infected with HIV. In Asia, coinfections are increasingly being reported in India, which also has the highest global burden of leishmaniasis and a high rate of resistance to antimonial drugs. Based on the previous experience of 20 years of coinfection in Europe, this review focuses on the management of Leishmania-HIV-coinfected patients in low-income countries where leishmaniasis is endemic.

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Section: Microbiologymentioning

confidence: 99%

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

et al. 2008

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“…This has already been reported by different studies in various Mediterranean countries: France (Pratlong et al 2004;Marty et al 2007), Portugal (Campino et al 2006), Spain (Jimenez et al 1995;Martin-Sanchez et al 2004), Algeria (Harrat et al 1996), Tunisia (Belhadj et al 2002, Kallel et al 2008 and Italy (Gramiccia et al 1992;Gramiccia, 2003). Out of these 37 zymodemes, 25 were not isolated from dogs, and were considered as small variants of zymodeme MON-1, scarce in humans and the reservoir of which remains unknown.…”

Section: Discussionmentioning

confidence: 81%

“…The dog is incontestably the reservoir host of L. infantum MON-1, in the Mediterranean basin, where it represents between 75 and 98·4% of the canine strains depending on the countries (reviewed by Aït Oudhia et al 2011) (87·2% in the present study). MON-1 has also been found in foxes in Portugal (Campino et al 2006), and previous studies described it as L. infantum wild reservoir host in different countries, including France (Rioux et al 1968), Italy (Bettini et al 1980), Spain (Portus et al 2002) and Portugal (Abranches et al 1983).…”

Section: Discussionmentioning

confidence: 99%

Geographical distribution and epidemiological features of Old WorldLeishmania infantumandLeishmania donovanifoci, based on the isoenzyme analysis of 2277 strains

et al. 2012

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A series of 2277 Leishmania strains from Old World visceral leishmaniasis foci, isolated between 1973 and 2008, were studied by isoenzyme analysis. The strains were obtained from humans, domestic and wild carnivores, rodents and phlebotomine sandflies, and came from 36 countries. In all, 60 different zymodemes were identified and clustered by a phenetic analysis into 3 different groups corresponding to the typically visceralizing species L. donovani (20 zymodemes, 169 strains), L. archibaldi (3 zymodemes, 46 strains) and L. infantum (37 zymodemes, 2,062 strains). The taxonomic position of these isoenzymatic groups is discussed in view of contradictory results obtained from recent molecular studies.

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“…L. infantum can cause CL, although visceral leishmaniasis is the most common presentation of the disease (Campino et al, 2006). The protozoon is an obligate intracellular parasite, infecting macrophages, which are essential in the formation of granulomas.…”

Section: Discussionmentioning

confidence: 99%

Relapsing Cutaneous Leishmaniasis in a Patient Treated with Humira

Otte¹,

Christiansen²,

Petersen³

2015

American Journal of Infectious Diseases

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Leishmanias is an anthropozoonosis caused by the Leishmania protozoa. The manifestation of the disease varies depending on the type of Leishmania and the immunestatus of the patient. Tumor Necrosis Factor (TNF)-α antagonists were introduced in the late 1990s and have had a marked impact on rheumatic diseases. Tumor necrosis factor plays an important role in the immune systems defense against intracellular infections and the use of TNF-α antagonists is linked with an increased frequency of infections. We here present a case of cutaneous leishmaniasis relapse following treatment with miltefosine and amphotericin B, in a patient undergoing treatment with a TNF-α antagonist.

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Leishmaniasis in Portugal: enzyme polymorphism of Leishmania infantum based on the identification of 213 strains

Abstract: SummaryThis study reports isoenzyme polymorphism of

Cited by 52 publications

References 26 publications

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

Geographical distribution and epidemiological features of Old WorldLeishmania infantumandLeishmania donovanifoci, based on the isoenzyme analysis of 2277 strains

Relapsing Cutaneous Leishmaniasis in a Patient Treated with Humira

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