Leishmania (Viannia) panamensis-Specific IgE and IgA Antibodies in Relation to Expression of Human Tegumentary Leishmaniasis

O’Neil, Carol E.; Labrada, Maricel; Saravia, Nancy Gore

doi:10.4269/ajtmh.1993.49.181

Cited by 17 publications

(14 citation statements)

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“…However, high levels of parasitic-specific serum IgE without B-cell polyclonal activation or hypergammaglobulinemia are also observed (21). In this work, we documented the occurrence of IgE antileishmanial antibodies in serum for 40% of the patients with early CL which can react with proteins with molecular masses ranging from 18.5 to 75 kDa.…”

Section: Discussionmentioning

confidence: 68%

“…The positive correlation between IgE antileishmanial antibodies and the diameter for the skin Montenegro test could be attributed to a synergistic effect of the late-phase inflammation originating with immune reaction of leishmanial antigens injected in the skin with specific IgE antibodies fixed on mast cells and the type IV hypersensitivity caused by this test. Finally, finding elements of the Th2 immune response in early CL, demonstrated by serum IgE antileishmanial antibodies and high concentrations of this immunoglobulin in the sera of infected patients (21), is in accordance with previous observations of IL-4 and IL-10 mRNA in cells from biopsies of leishmanial skin ulcers (3,11,19,23). Previous study has shown a preferential IL-10 production to the detriment of IFN-␥ in early CL, with the change of this pattern occurring during the evolution of the infection, where the proinflammatory Th1 cytokine predominates (24).…”

Section: Discussionmentioning

confidence: 99%

“…Unlike the case with VL, patients with CL have a strong Th1 immune response, evidenced by a positive type IV hypersensitivity skin reaction and high IFN-␥ production by peripheral blood mononuclear cells stimulated ex vivo by leishmanial antigens (6,9). Nevertheless, evidence of a Th2 immune response has been reported with this disease, as high levels of serum IgE and mRNA for IL-4, IL-5, and IL-10 in skin biopsies of leishmanial ulcers (3,11,19,21,23). In this work we evaluated the occurrence of IgE antibodies to leishmanial antigens in sera from CL patients and looked for a relationship between the presence of this isotype of antibody and the following parameters: clinical features, positivity in skin Montenegro test, and therapeutic response to conventional chemotherapy with a pentavalent antimonial.…”

mentioning

confidence: 99%

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Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis

Sousa-Atta

Salamé

Júnior

et al. 2002

Clin Vaccine Immunol

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High levels of antileishmanial immunoglobulin E (IgE) antibodies are associated with disease activity in visceral leishmaniasis. Herein, we report our observations about the relationship between antileishmanial IgE antibodies and clinical aspects of cutaneous leishmaniasis. This study was carried out with 45 patients (29 male and 16 female), with ages ranging from 11 to 48 years. All subjects were from an area to which leishmaniasis is endemic, Corte de Pedra (Bahia, Brazil), and the duration of the illness was <30 days. The patients were classified as positive or negative for IgE serology in enzyme-linked immunosorbent assay with leishmanial antigens. IgE antibodies were detected in 18 patients (optical density, 0.421 ؎ 0.30; 95% confidence interval, 0.27 to 0.57), and only 3 (17%) had more than one ulcer. In this group the diameter of Montenegro's reaction was 18 ؎ 12.2 mm. In the group with negative IgE serology, 11 of 27 patients (48%) presented two or more cutaneous ulcers, and the mean of the skin test result was 9 ؎ 6.9 mm. There was a positive correlation between IgE antibody levels and Montenegro's reaction size and an inverse correlation between IgE antileishmanial antibodies and the number of skin ulcers. The presence of antileishmanial IgE antibodies in cutaneous leishmaniasis may be a result of immunoregulatory events with clinical implications.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis

Sousa-Atta

Salamé

Júnior

et al. 2002

Clin Vaccine Immunol

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“…CL is characterized by a mixed Th-1/Th-2 immune response during the early phase then Th-2 is detected and converts to an evident Th-1 type of immune response documented by lymphocyte proliferation and IFN-c secretion. (O'Neil et al 1993).…”

Section: Interleukin-4mentioning

confidence: 99%

Comparative immune study on cutaneous leishmaniasis patients with single and multiple sores

2013

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Ninety-five Iraqi patients with cutaneous leishmaniasis (CL) caused by Leishmania tropica at AL-Karama Hospital in Baghdad were included in this study. Sixty patients were with single sore and the remaining with multiple sores. The study also included 10 atopic patients and 30 healthy individuals as a control group. Cellular and humoral immune response at different stages of the disease activity (early and late) were evaluated by estimation of serum IFNc, IL-4 and total IgE antibodies using ELISA kits while, the detection of specific anti leishmanial IgE antibodies was done manually. Specific IgE antibodies were only detected in early CL (\2 months) patients 68 (71.57 %) while, were not detected in late CL, atopic and healthy controls 30 (100 %). The results also showed a positive relationship between this antibody and the number of sores. Th-2 predominates during the early stage of the disease then shifts to Th-1 that proceed in the late stage, but both cytokines increased in CL patients in comparison to control group. The immune response of CL infection is possibly regulated by both Th-1 and Th-2. Multiple sores patients showed an increase of anti leishmanial IgE (0.120 ± 0.014), total IgE (120.7 ± 39.58 IU/ml), IFN-c (87.4 ± 30.52 pg/ml) and IL-4 (63.70 ± 20.32 pg/ml) levels than single sore patients with mean value of 0.108 ± 0.14, 92.3 ± 35.23 IU/ml, 47.2 ± 27.80 pg/ml and 51.04 ± 15.0 pg/ml respectively. It can be presented also as ratio of INF-c/IL-4 = 1.37 which is greater than those for single sore 0.9. These results indicated that the immune response of multiple sores patient's is higher than that with single sores.

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“…Esses dados estão de acordo com outros autores 19 , que também demonstraram elevação dos níveis de anticorpos IgA-Leishmania específicos em pacientes com comprometimento mucoso.…”

Section: Discussionunclassified

Perfil de isotipos de imunoglobulinas e subclasses de IgG na leishmaniose tegumentar americana

Souza

Afonso-Cardoso

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMOParasitas do gênero Leishmania são protozoários intracelulares obrigatórios que causam um complexo de enfermidades no homem e animais denominadas leishmanioses. Essas infecções atingem cerca de 12 milhões de pessoas em todo o mundo e são consideradas uma das dez principais doenças tropicais pela Organização Mundial da Saúde 27 . De acordo com este órgão, a forma tegumentar dessa parasitose é a apresentação clínica mais comum, acometendo cerca de 75% dos casos e constituindo um grave problema de saúde pública. A importância dessa moléstia não se deve apenas à sua alta incidência e ampla

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Leishmania (Viannia) panamensis-Specific IgE and IgA Antibodies in Relation to Expression of Human Tegumentary Leishmaniasis

Cited by 17 publications

References 0 publications

Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis

Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis

Comparative immune study on cutaneous leishmaniasis patients with single and multiple sores

Perfil de isotipos de imunoglobulinas e subclasses de IgG na leishmaniose tegumentar americana

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