Leiomyosarcoma of the urinary bladder in a patient with bilateral retinoblastoma

Abstract

Abstract:We report a case of bladder leiomyosarcoma in a 27-year-old woman who had previously been treated with surgery and radiation for bilateral retinoblastoma. The patient was admitted to hospital with discomfort on micturition. Cystoscopy revealed a bladder tumor covered by normal urothelium. Transurethral resection of the bladder tumor was performed , and the histopathological diagnosis was leiomyosarcoma. Partial cystectomy was performed. The leiomyosarcoma of the bladder did not invade the muscle layer. However, bladder tumors recurred at new intravesical locations repeatedly. After transurethral resection of the bladder tumor had been performed twice, total cystectomy and creation of an ileal conduit were performed.

Urinary bladder leiomyosarcoma following radiotherapy in a patient with bilateral retinoblastoma: A case report

“…Minogawa et al .,[ 4 ] reported a case similar to ours wherein a 27-year-old woman with bilateral retinoblastoma had been treated with surgery and radiation. They suggested that along with RB1 gene and chemotherapy, other genetic factors might also be associated with bladder leiomyosarcoma in retinoblastoma patients.…”

“…They suggested that along with RB1 gene and chemotherapy, other genetic factors might also be associated with bladder leiomyosarcoma in retinoblastoma patients. [ 4 ]…”

Organ preservation in leiomyosarcoma bladder: Case report and review of literature

“…Bladder leiomyoma in contrast to LMS are noninfiltrative smooth muscle tumors, lacking mitotic activity, cytologic atypia, and necrosis. [ 5 ] Other spindle cell lesions including, sarcomatoid carcinoma, inflammatory myofibroblastic tumor, and postoperative spindle cell nodule need to be distinguished from LMS. This is usually accomplished by histology and immunochemistry.…”

Spindle cell lesions of the bladder and urinary tract

“…CK expression is typically focal, if present. There are multiple cases reported as leiomyosarcoma arising in long‐term survivors of retinoblastoma, 61–67 some but not all of whom received chemotherapy (mainly cyclophosphamide). There are occasional cases in patients receiving cyclophosphamide for other conditions such as Hodgkin’s lymphoma 68,69 or lupus nephritis 70 .…”