Leiomyosarcoma of the inferior vena cava

Chzhao, Alexey V.; Зотиков, А. Е.; Kаrmаzаnovsky, G. G.; Гурмиков, Б. Н.; Ивандаев, А. С.

doi:10.1016/j.jvscit.2020.04.001

Cited by 6 publications

(5 citation statements)

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“…9 With the developments of cardiopulmonary bypass and the commencement of multidisciplinary collaboration, surgical treatment became feasible. 8,9,11,12 The first resection of the IVC tumor was recorded at Lexington Memorial Hospital in 1951. 10 In 1974, Mandelbaum et al reported the first successful resection of IVC leiomyoma involving right atrium .…”

Section: Discussionmentioning

confidence: 99%

A 10-year experience of leiomyosarcoma of the inferior vena cava

Pan

Qiu

et al. 2022

Phlebology

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Objectives Leiomyosarcoma of the inferior vena cava (IVC) is rare. The study reviewed patients with IVC leiomyosarcoma in our hospital in the past ten years. Methods Twenty patients diagnosed with IVC leiomyosarcoma between October 2010 and October 2020 were enrolled. Their clinical manifestations, treatments, and follow-up results were analyzed. Results The sarcoma was located in the lower IVC segment in six patients, with 13 in the middle and one in the upper IVC segment. Eighteen patients underwent R0 resection. After resection, 16 patients (80%) had primary repair of the IVC, while four patients underwent ligation. During a mean follow-up of 37.7 months, seven patients died due to tumor metastasis, four patients were alive with the tumor recurrence and other nine patients were alive without recurrence. Conclusion The management of the IVC after tumor resection depended on the tumor location and size. R0 resection provided a chance for long term survival.

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Section: Discussionmentioning

confidence: 99%

A 10-year experience of leiomyosarcoma of the inferior vena cava

Pan

Qiu

et al. 2022

Phlebology

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“…[9] With the developments of cardiopulmonary bypass and the commencement of multidisciplinary collaboration, surgical treatment became feasible. [8,9,11,12] The rst resection of the IVC tumor was recorded at Lexington Memorial Hospital in 1951. [10] In 1974, Mandelbaum et al reported the rst successful resection of IVC leiomyoma involving right atrium.…”

Section: Discussionmentioning

confidence: 99%

A 10-Year Experience of Leiomyosarcoma of the Inferior Vena Cava

Qiu

Xue

et al. 2021

Preprint

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Background: Leiomyosarcoma of the inferior vena cava (IVC) is rare. The study reviewed patients with IVC leiomyosarcoma in our hospital in the past ten years.Methods: 20 patients diagnosed with IVC leiomyosarcoma between October 2010 and October 2020 were enrolled. Their clinical manifestations, treatments and follow-up results were analyzed.Results: The sarcoma was located in the lower IVC segment in six patients, with 13 in the middle IVC segment and one in the upper IVC segment. The median tumor size was 8.5 cm (range 2.5-27.0). Except for two patients who underwent partial resection, other patients underwent R0 resection. After resection, 16 patients (80%) had primary repair of the IVC, while four patients underwent ligation. Three patients with tumors invading the renal vein but not the kidney underwent renal vein revascularization. There was no perioperative death. During a mean follow-up of 37.7 months, seven patients died due to tumor metastasis, four patients were alive with the tumor recurrence and other nine patients were alive without recurrence.Conclusion: The perioperative mortality was low. The management of the IVC after tumor resection depended on the tumor location and size. R0 resection provided a chance for long term survival.

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“…Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle of gastrointestinal and vascular wall and accounts for 5%-10% of soft tissue tumors [1] . Primary leiomyosarcomas is originated from inferior vena cava (IVC) wall and presents as a very rare clinical entity [2] . It grows slow and insidiously without significant symptoms at early stage; thus, it is extensively advanced with multi-organ and vascular involvement when the diagnosis of leiomyosarcoma is confirmed [3,4] .…”

Section: Introductionmentioning

confidence: 99%

“…[ 1 ] Primary leiomyosarcomas is originated from inferior vena cava (IVC) wall and presents as a very rare clinical entity. [ 2 ] It grows slow and insidiously without significant symptoms at early stage; thus, it is extensively advanced with multi-organ and vascular involvement when the diagnosis of leiomyosarcoma is confirmed. [ 3 , 4 ] With the advancement of surgical oncology and its adjuncts, radical resection has become the only curative option considering poor clinical efficacy of chemo and radio-therapy.…”

Section: Introductionmentioning

confidence: 99%

Surgical management strategy for leiomyosarcoma of Zone I-II inferior vena cava

Tulahong¹,

Tuxun²,

Yao³

et al. 2022

Medicine

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Objectives: Leiomyosarcoma of inferior vena cava (IVC) is a rare clinical entity with severe vascular involvement. Surgical management of leiomyosarcoma is still challenging.Methods: This a retrospective study of consecutive patients referred to our hospital from January 2017 to June 2019. Depending on the anatomical site of affected IVC, leiomyosarcomas were categorized into zone I-II. The clinical data including baseline information, surgical parameters, peri-operative management, short-and mid-term outcomes were observed.Results: Four patients with leiomyosarcoma of zone I-III underwent radical resection without intraoperative mortality. Prosthetic grafts were interpositioned in all patients to instruct vena cava. Renal vein reconstruction was perfumed in two patients due to involvement to renal veins. Median blood loss was 450 mL (200-600 mL), median operative time was 215 minutes (150-240 minutes). No Clavien-Dindo IIIa or higher complication was observed. No organ dysfunction and recurrence were observed with median follow-up of 25.5 months.Conclusions: Curative resection of zone I-II leiomyosarcoma is associated with longer survival in selected cases, en-bloc resection with complex vascular reconstruction could be considered.Abbreviations: CT = computed tomography, DFS = disease free survival, IVC = inferior vena cava, OS = overall survival.

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Leiomyosarcoma of the inferior vena cava

Cited by 6 publications

References 5 publications

A 10-year experience of leiomyosarcoma of the inferior vena cava

A 10-year experience of leiomyosarcoma of the inferior vena cava

A 10-Year Experience of Leiomyosarcoma of the Inferior Vena Cava

Surgical management strategy for leiomyosarcoma of Zone I-II inferior vena cava

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