Leiomyosarcoma of inferior vena cava producing Budd‐Chiari syndrome

Cardell, B. S.; McGill, D. A. F.; Williams, Roger

doi:10.1002/path.1711040411

Cited by 22 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumor had a tendency to remain confined to its capsule and the overlying adventitia remained intact. Such confines were violated in seven cases (5.3%) [16,17,[23][24][25][26]. In some cases the liver was described as being ''infiltrated by tumor in the region of the hepatic veins.''…”

Section: Pathologic Featuresmentioning

confidence: 99%

“…Interference with the circulation on the right side of the heart by the tumor or tumor thrombus resulted in a host of manifestations. Patients presented with clinical picture of constrictive pericarditis, cardiac valvular, hepatic, renal, or pulmonary disease, idiopathic IVC thrombosis, deep vein thrombosis, or pulmonary embolism [2,3,9,12,13,[19][20][21]23,29,33,39,[49][50][51][52][53][54][55]. Budd-Chiari syndrome (BCS) (hepatomegaly, ascites, anasarca, hepatic failure and coma) developed in one-fourth of the cases.…”

Section: Clinical Presentationmentioning

confidence: 99%

See 1 more Smart Citation

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

et al. 1997

View full text Add to dashboard Cite

Background and Objectives We operated on three patients with leiomyosarcoma of the inferior vena cava. Methods Complete excision was possible in all three patients. Results One patient developed widespread metastasis at 23 months, one patient is alive with no evidence of disease at 70 months, and one patient is alive at 15 months. The third patient had subcutaneous and pulmonary metastases at the time of presentation, which are radiologically nondetectable at present following postoperative chemotherapy. Conclusions The clinicopathologic features, prognostic factors, and treatment of 130 cases found in a comprehensive literature search and our three cases are reported. J. Surg. Oncol. 1997;65:205–217. © 1997 Wiley‐Liss, Inc.

show abstract

Section: Pathologic Featuresmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

et al. 1997

View full text Add to dashboard Cite

show abstract

“…Since metastasis from another organ had been excluded, based on preoperative CTand Ga scintigram findings, we considered the possibility of a primary inferior vena cava rhabdomyosarcoma. Although about 100 cases of primary inferior vena cava leiomyosarcoma have been reported world wide (3)(4)(5)(6)(7)(8)(9), there have been no reports of rhabdomyosarcoma. In addition, only 6 cases of rhabdomyosarcoma to originating in the blood vessels have been reported.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma in the Inferior Vena Cava with Secondary Budd-Chiari Syndrome.

et al. 1993

View full text Add to dashboard Cite

A63-year-old manwith symptomsof obstruction of the inferior vena cava was examined by computed tomography, ultrasound imaging and angiography. Examination revealed a tumor in the inferior vena cava, and transvenous biopsy revealed a rhabdomyosarcoma. The tumor was surgically resected and was easily separated from the surrounding tissues. Nevertheless, a local recurrence developed 43 days after the operation, and the patient's condition deteriorated rapidly. Hepatomegaly and ascites believed to represent the Budd-Chiari syndrome were noted.The patient died on the 163rd postoperative day. Autopsy revealed a tumor extending from the inferior vena cava just above the right renal vein to the right atrium and involving the lobus caudatus of the liver. Clinically, the tumor was thought to have arisen from the middle segment of the inferior vena cava. However, a diagnosis of primary hepatic rhabdomyosarcomawith extrahepatic growth could not be excluded. Only 12 cases of primary liver rhabdomyosarcoma have been reported, and none of those patients demonstrated Budd-Chiari syndrome. Our patient, diagnosed as rhabdomyosarcoma with secondary Budd-Chiari syndrome, is believed to be the first such report. (Internal: Medicine 32: 67-71, 1993)

show abstract

“…1,3,5 Tumors of the upper third of the inferior vena cava are, however, more overt and often present as a variant of the Budd-Chiari syndrome. [5][6][7][8][9][10][11][12] In patients presenting with an abdominal mass, ultrasonography and CT scan should demonstrate the anatomical proximity of the tumor and inferior vena cava. Venacavography will confirm the site of origin and assess the operability.…”

Section: Perlmentioning

confidence: 99%

Leiomyosarcoma of the Inferior Vena Cava: Report of Two Cases and Review of the Literature

1989

View full text Add to dashboard Cite

Leiomyosarcoma of vascular origin is a rare and usually lethal tumor. It arises more commonly from large veins than arteries, and more than one half occur in the inferior vena cava.1 Most of these tumors are diagnosed at autopsy or laparotomy. Surgical resection offers the best prospect of cure; however, the majority of patients die from metastatic lesions into the liver and lungs.The purpose of this report is to describe two cases of leiomyosarcoma of the inferior vena cava. Case Reports Case 1A 35-year-old Saudi woman was admitted with a 14-year history of an intermittent dull ache in the right hypochondrium. The pain had no relationship to meals, and there was no history of weight loss or other relevant complaints. Physical examination revealed a large, nontender, firm abdominal mass in the right flank. Results of routine hematological investigations, including complete blood cell count, erythrocyte sedimentation rate, urea, and electrolytes, and liver function tests were all normal. Ultrasound examination of the abdomen revealed a 9 × 5 × 9-cm solid mass in the right flank and a single stone in the right kidney. The liver and spleen appeared normal, and there were no other masses in the abdomen or pelvis. Findings on subsequent radiologic investigations, which included chest x-ray, liver and spleen isotope scan, intravenous urogram, and barium enema, were all reported normal.At laparotomy the mass was retroperitoneal, arising from the inferior vena cava at the level of the right renal vein and extending superiorly to within 2.5 cm of the most inferior hepatic vein. The left renal vein was not involved in the tumor mass. The inferior vena cava was completely occluded. The mass was separated from surrounding structures by sharp and blunt dissection, then completely resected together with the right kidney. The two ends of the inferior vena cava were closed with a continuous suture. There were no other abnormal findings in the abdomen. Postoperative recovery was uneventful. Histopathologic examination of the resected mass showed leiomyosarcoma arising from the inferior vena cava.The patient is well and alive 23 months later with no signs of metastases or lower limb edema, and renal function is normal. Case 2A 55-year-old Saudi woman was admitted for further investigations of right flank pain, which was vague in nature and associated with indigestion and increasing constipation of 7 months' duration. Three months before admission, there was increasing puffiness of the face and swelling of both lower limbs. There was no history of jaundice or shortness of breath, nor was there any history of gynecologic problems. The patient was a known diabetic and had been treated with oral hypoglycemic drugs for the last 9 years. She was moderately obese, and apart from the puffiness of the face and minor edema of the lower limbs, the physical examination was normal.Laboratory studies showed normal blood cell count, but the ESR was high at 66 mm/h. Blood urea and creatinine were elevated at 12 mmol/L and 185 mmol/L, respectivel...

show abstract

Leiomyosarcoma of inferior vena cava producing Budd‐Chiari syndrome

Cited by 22 publications

References 9 publications

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

Leiomyosarcoma of the inferior vena cava: A clinicopathologic review and report of three cases

Rhabdomyosarcoma in the Inferior Vena Cava with Secondary Budd-Chiari Syndrome.

Leiomyosarcoma of the Inferior Vena Cava: Report of Two Cases and Review of the Literature

Contact Info

Product

Resources

About