Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas

Leibsohn, Steven; d'Ablaing, Gerrit; Mishell,; Schlaerth, JB

doi:10.1016/0020-7292(91)90261-3

Cited by 85 publications

(120 citation statements)

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“…La relation entre myomes et sarcomes n'a jamais été prouvée [12] ; et la littérature ne rapporte que 2 sarcomes pour 1 000 fibromes [5,8,17].…”

Section: Discussionunclassified

“…Parmi les facteurs de bon pronostic : l'âge, la préménopause, l'absence de nécrose ou de hyalinisation péritumorale, l'absence d'invasion vasculaire, myométriale et/ou extra-utérine comme l'association à un léiomyome bénin sont cités par la plupart des auteurs [1,8,12,21]. Par contre plus l'index mitotique est élevé plus sombre est le pronostic [12,14,21].…”

Section: Pronosticunclassified

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Sarcomes utérins: à propos de 5 cas et revue de la littérature

et al. 2005

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“…La relation entre myomes et sarcomes n'a jamais été prouvée [12] ; et la littérature ne rapporte que 2 sarcomes pour 1 000 fibromes [5,8,17].…”

Section: Discussionunclassified

Section: Pronosticunclassified

Sarcomes utérins: à propos de 5 cas et revue de la littérature

et al. 2005

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“…However, the exact incidence of leiomyosarcoma in uteri removed for benign uterine myoma has not been reported. According to FDI the incidence is 1:375, whereas Leibsohn et al 8 found the incidence to be 1% (8 of 817) of leiomyosarcoma, between the ages of 40 and 60 years, in preoperatively presumed benign leiomyomas. Our own incidence in Apollo Hospital has been about 1 in 130 for the last 10 years.…”

Section: Controversiesmentioning

confidence: 95%

Challenges & controversies in robotic myomectomy

Khanna

Dash

2015

Apollo Medicine

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IntroductionUterine fibroids are the most common indication for hysterectomy in most parts of the world. Incidence varies from 5% to 21% between the ages of 35 and 49 years. 1 In African-American women, the incidence is higher, increasing to >80% by age 50, whereas Caucasian woman have an incidence of 40% by age 35 and about 70% by age 50. 2 Majority of women with uterine fibroids are asymptomatic. Abnormal uterine bleeding, dysmenorrhea, pelvic pain, infertility, and prevalence of a mass in lower abdomen or recurrent miscarriages are the common symptoms in some cases. The treatment done traditionally was to remove fibroids by an operation abdominally or vaginally. Since the last few decades, laparoscopy evolved as a minimal access surgery with its inherent benefits of short hospital stay, less post-operative pain, better cosmetic result, and faster return to normal activities.In 2005, the da Vinci ® Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) was the first robot approved by US FDA for gynecological surgeries. The largest body of experience in robotic surgery in gynecology exists with supracervical TLH, myomectomy, tubal anastomosis, sacrocolpopexy, and cancer staging and its treatment. The advantages of robotic surgery over laparoscopy are a 3-dimensional image, superior instrument articulation, and comfort for surgeon. The multilayer suturing is easier by a robot than by laparoscopy, and a further advantage is that the tremor of the surgeon is totally absent. a p o l l o m e d i c i n e 1 2 ( 2 0 1 5 ) 8 7 -9 0 a b s t r a c t Robotic surgery for gynecology is being performed since 2005. For myomectomy, it is a better technology since suturing of myoma bed is better with lower incidence of scar rupture.However, the morcellation for the myoma retrieval has to be done carefully in a bag, and preoperative investigation should be done to exclude occult leiomyosarcoma.

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“…A biopsy should be obtained for pathologic diagnosis. Occasionally, uterine sarcoma is found at pathologic examination of a hysterectomy or myomectomy specimen from surgery performed for presumed benign disease [8,9].…”

Section: Introductionmentioning

confidence: 99%

Uterine/female genital sarcomas

Hensley

2000

Curr. Treat. Options in Oncol.

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Choosing the best management of uterine and vulvo-vaginal sarcomas depends on careful histologic review of the pathologic specimen. Prognosis and treatment vary greatly depending on specific histology, grade, and tumor stage. The initial approach to sarcomas of the female genital tract, with the occasional exception of vulvo-vaginal rhabdomyosarcoma, is surgery. Adjuvant radiation decreases local recurrence rates for uterine sarcomas, but has not been clearly shown to improve overall survival. It is frequently used as adjuvant therapy for resected high-grade or margin-positive vulvo-vaginal sarcomas, and for endometrial stromal sarcomas. Adjuvant chemotherapy has not been demonstrated to improve survival in vulvo-vaginal sarcomas, with the exception of vulvo-vaginal rhabdomyosarcomas, nor has it been demonstrated to improve survival in uterine sarcomas. Chemotherapy may be used for recurrent or persistent disease. The choice of agent depends on the histologic type of sarcoma.

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Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas

Cited by 85 publications

References 0 publications

Sarcomes utérins: à propos de 5 cas et revue de la littérature

Sarcomes utérins: à propos de 5 cas et revue de la littérature

Challenges & controversies in robotic myomectomy

Uterine/female genital sarcomas

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