Uterine/female genital sarcomas

Hensley, Martee L.

doi:10.1007/s11864-000-0061-6

Cited by 19 publications

(19 citation statements)

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“…Similar to uterine leiomyosarcoma, WT1 overexpression in endometrial stromal sarcoma is a potential target for immunotherapy. 36 It is also believed that abnormalities in chromosomes 1, 7, and 11 may play an important role in the genesis of sarcomas or their progression. Changes in 11q22, the expression of epidermal growth factor receptors (HER-2/neu), p53, and Ki-67 were also described in malignant tumors of the uterus.…”

Section: Molecular Features Of Gynecological Sarcomasmentioning

confidence: 99%

“…35 Evaluation of the spread of extrapelvic structures should be performed by computed tomography of the thorax and abdomen. 36 The distant spread of sarcomas often involves the lungs. Tomography of the thorax is highly sensitive for the detection of pulmonary metastases.…”

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confidence: 99%

“…35 Although several features at ultrasonography and magnetic resonance imaging (MRI) can raise suspicion of a uterine sarcoma, there are no pathognomonic features on any imaging technique. 36 Complete staging includes cytology and a biopsy of any suspicious areas of metastasis, as is the case for other intraabdominal gynecologic malignancies. The tumor-free resection margin is recommended and has great importance.…”

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confidence: 99%

“…A total abdominal hysterectomy with bilateral salpingo-oophorectomy is the standard surgical treatment. 36 Total hysterectomy is essential when a uterine sarcoma is suspected, and it may be curative if the tumor is confined to the uterus. In the case of a preoperative diagnosis of endometrial stromal sarcoma, a radical hysterectomy is recommended due to the frequent involvement of the parametrium, which sometimes only presents invasion in the intravascular space.…”

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confidence: 99%

“…Hormonal treatment or surgery can, therefore, be considered first instead of chemotherapy. 36 The effect of optimal cytoreduction on the survival of women with disease presenting extra-uterine spread has only been evaluated in few studies, and the findings are inconsistent. Currently it is not possible to define an optimal cytoreduction for uterine sarcomas.…”

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confidence: 99%

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Clinical and molecular features of uterine sarcomas

Almeida¹,

Cunha²,

Maciel³

et al. 2014

Medical Express

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INTRODUCTION: Uterine sarcomas are rare forms of malignant neoplasm, comprising about 3% of all malignant uterine tumors, representing less than 1% of all gynecologic malignancies. Low cure rates often occur due mainly to distant metastases, usually to the lungs. Aggressiveness, high rates of local recurrence, distant metastasis and poor prognosis with overall two-year survival less than 50% are common features of uterine sarcomas. Despite the low prevalence, these tumors are of great interest because of their multiple morphological and clinical features. OBJECTIVE: This article will be focused on the uterine sarcomas general aspects, etiology, prognosis, treatment and molecular features. METHOD: This review was performed using the Pubmed database to search for published articles. RESULTS: Little is known about the etiology of uterine sarcomas. Some studies have demonstrated the association between genetic events involving mutations in genes of the cell cycle and apoptosis and epigenetic in gynecologic sarcomas. Previous studies showed that chromosomal translocations have been identified, resulting in fusion genes that are constitutive and might involve the activation of transcription factors. Advances in molecular techniques have improved the diagnostic possibilities and allowed an improved understanding of the various pathologies. CONCLUSIONS: There are several factors that make the study of sarcomas a challenging issue, since those tumors are rare and the cell origin of each histologic type is nor well known Thus, molecular study of the events involved in the development of different types of cancer may lead to new strategies used in the diagnosis and treatment of these tumors.

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Section: Molecular Features Of Gynecological Sarcomasmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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