Legitimate Indications for Intramuscular Injections

In-vitro prediction of bioavailability following extravascular injection of poorly soluble drugs: an insight into clinical failure and the role of delivery systems

“…The initial precipitation observed with DZP reduced over time, possibly due to the precipitate being amorphous or a polymorph, which could readily redissolve. This supports reports of biphasic intramuscular absorption of DZP . Additionally, high inter‐individual variability was observed for absorption parameters ( C max and t max ) after intramuscular injection of DZP, resulting in clinical failure in some cases.…”