Leg-Vein Thrombosis Following Myocardial Infarction

Heparin in the Prevention of Deep Vein Thrombosis after Myocardial Infarction

“…However, in the two patients in the present series who developed pulmonary emboli deep vein thrombosis was apparently confined to the calf; in the patient who died this was confirmed at necropsy. These findings agree with those of Murray et al (1970); they found evidence of pulmonary embolism after myocardial infarction in 4 out of 12 patients with thrombosis below the knee, but in none of those with normal radioactivity counts. It is accepted that the fibrinogen test cannot detect thrombi above mid-thigh level with any degree of accuracy (Flanc et al, 1968;Negus and Evans, 1971), so some of these patients may also have had undetected iliofemoral thrombosis.…”

“…With this technique the incidence of venous thrombosis in the control group was 29%. This is slightly lower than that reported by other authors (Murray et al, 1970;Maurer et al, 1971;Nicolaides et al, 1971), presumably because they included the high-risk older age group (Maurer et al, 1971).…”

Myocardial Infarction and Deep-vein Thrombosis

“…The findings of this preliminary study support the relatively high incidence of deep-vein thrombosis recently reported in patients with acute myocardial infarction (Murray et al, 1970). Above all, however, they show that those patients who are "severely ill" are by far the most likely to develop deepvein thrombosis (62%).…”

Changes in Coagulation Factors Following Acute Myocardial Infarction in Man

“…Experimental data favours the view that it is the activity of coagulation factors rather than their concentration which is important in the induction of thrombosis [29], It is probable that most venous thromboses following surgery or myocardial infarction are initiated during or soon after the stress situation [11,14,18,22,23]: it is, therefore, of interest that a shortening of the clotting time in polystyrene tubes, an indication of the presence of an increase in the procoagulant activity of one or more clotting factors, was found only on the 1st postinfarction day. The significance of increases in the concentration of factors VIII, IX and XI following myocardial infarction is uncertain: these rises occurred after a few days and coincided with the period when many cases of venous thrombosis become clinically apparent, but it is unlikely they can be relevant to the initiation process.…”