Leg ulcers in systemic lupus erythematosus associated with underlying dystrophic calcinosis and bone infarcts in the absence of antiphospholipid antibodies

Lederhandler, Margo; Valins, Whitney; Zoghbi, Zena; Grossman, Marc E.

doi:10.1016/j.jdcr.2016.02.009

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…Osteonecrosis of the metaphysis or diaphysis of the bone is referred to as bone infarction and is rarely seen in SLE. 15 In our patient bone infarction was found in tip of great toe of right foot and distal phalanx of left little finger.…”

Section: Discussionmentioning

confidence: 44%

Earlier Development of Limb Ulcers, Digital Bone Infarction and Pulmonary Hypertension in a Patient with SLE- A Rare Case Report

Chakrabarty

Sultana

et al. 2017

J. Bangladesh Coll. Phys.

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Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease in which skin is involved in up to 85% of cases. Lower extremity ulcers are an infrequent but disabling complication of SLE. Critical peripheral ischemia (CPI) is also an uncommon but potentially devastating feature of SLE. We reported a case o f SLE who presented with multiple ulcers along with digital infarcts of upper and lower limbs. She had features of digital bone infarct of left hand and right foot. She also had features of pulmonary interstitial involvement with pulmonary hypertension. All of these features were found within three months of disease onset which is very rare. She was treated with intravenous Methylprednisolone followed by oral Prednisolone, Hydroxychloroquinine, Azathioprine, Diuretic, Bosentan, Aspirin and Nifedipine in combinaton. Later warfarin was added after one month. She showed significant improvement after three months of treatment.J Bangladesh Coll Phys Surg 2017; 35(3): 150-154

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Section: Discussionmentioning

confidence: 44%

Earlier Development of Limb Ulcers, Digital Bone Infarction and Pulmonary Hypertension in a Patient with SLE- A Rare Case Report

Chakrabarty

Sultana

et al. 2017

J. Bangladesh Coll. Phys.

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“…11,14 Shallow calcifications creating nonhealing ulcers may occur with the presence of white-colored exudation containing calcium salt crystals. 15 In some cases, calcifications were localized in the deeper layers of the dermis and in the subcutaneous tissue, without visible changes on the skin surface or accompanied by atrophic scars. 16 The mechanism of the formation of dystrophic calcifications in connective tissue diseases is unclear.…”

Section: Resultsmentioning

confidence: 99%

Dystrophic calcifications in case of a patient with systemic lupus erythematosus – case report and literature review

et al. 2021

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Introduction: Cutis calcification is the deposition of calcium in the skin and subcutaneous tissues and is classified into four subsets. Dystrophic calcifications are the most common type of skin calcification, occurring mainly in damaged tissues or in course of autoimmune disease. However, the coexistance of systemic lupus erythematosus (SLE) and soft tissue calcification is described rarely. Aim: This article presents a case of dystrophic calcifications in the buttocks area in a 49-year-old woman with a 17-year history of SLE. Case study: We report a case of 49-year-old women with SLE who developed nodular lesions in the buttock area. The radiological and histopatological examinations of the nodules showed presence of calcifications. The calcium metabolism parameters were in a normal range. The diagnosis of dystrophic calcinosis in the course of SLE was established. Results and discussion: Dystrophic calcifications associated with autoimmune diseases are common, but occur rarely in SLE. It should be noted that patients with SLE can also develop calcifications of different types like metastatic or iatrogenic. Dystrophic calcifications in SLE usually present as small nodules on buttocks or limbs. The pathophysiology remains unclear, however, there are some theories that inflammation and vascular ischemia play a role in its process. Conclusions: Calcifications in case of patients with SLE rarely require treatment. Several pharmacologic and surgical therapies have been tested with variable results. Additional research to establish an accepted treatment algorithm should be conducted.

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“…These calcifications are an indication of previous microscopic cell injury. 4,5 It is likely that the combination of long-term bladderwall injury from IC, diathermy to the Hunner's ulcers, and trauma from repetitive steroidal injections had led to this severe complication. Fortunately, the patient made a successful recovery post partial cystectomy which resulted in an improved quality of life.…”

Section: Discussionmentioning

confidence: 99%

Can intravesical steroid injections cause bladder-wall calcification? A case report of a rare therapeutic complication for interstitial cystitis

Saadat¹,

Kiosoglous²

2017

Journal of Clinical Urology

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Leg ulcers in systemic lupus erythematosus associated with underlying dystrophic calcinosis and bone infarcts in the absence of antiphospholipid antibodies

Cited by 7 publications

References 12 publications

Earlier Development of Limb Ulcers, Digital Bone Infarction and Pulmonary Hypertension in a Patient with SLE- A Rare Case Report

Earlier Development of Limb Ulcers, Digital Bone Infarction and Pulmonary Hypertension in a Patient with SLE- A Rare Case Report

Dystrophic calcifications in case of a patient with systemic lupus erythematosus – case report and literature review

Can intravesical steroid injections cause bladder-wall calcification? A case report of a rare therapeutic complication for interstitial cystitis

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