Leg intramuscular pressures during locomotion in humans

Ballard, R. E.; Watenpaugh, Donald E.; Breit, G.; Murthy, G. G. Krishna; Holley, Daniel C.; Hargens, Alan R.

doi:10.1152/jappl.1998.84.6.1976

Cited by 63 publications

(56 citation statements)

References 24 publications

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“…The control cells were incubated with the same medium under normal pressure for 3 h at 37°C. The intensity of the pressure was based on the value of intramuscular pressure during walking reported by Ballard et al (1). In our previous report (17), we verified that the pH of the medium under both conditions was similar (pH 7.41 Ϯ 0.02).…”

Section: Methodssupporting

confidence: 74%

“…The former stimulus is developed during elongation of muscle length by external-strain force. On the other hand, intramuscular pressure is generated by contraction (i.e., force production) of the pressure-applied muscle itself, independent of alterations in muscle length (1). The effects of stretching stimuli on metabolism, intracellular signal events, and gene expression in skeletal muscle tissues or cells have been shown (3,6,9,15,16).…”

mentioning

confidence: 99%

“…With regard to intramuscular pressure, Ballard et al (1) demonstrated that the intramuscular pressures at concentric contraction during walking and running were ϳ180 and 270 mmHg, respectively. However, very little is known about the effects of a pressure stimulus as a component of mechanical forces during contraction on the physiological and biochemical responses of skeletal muscles.…”

mentioning

confidence: 99%

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Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts

Morita¹,

Iizuka²,

Okita³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

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.-Contraction of skeletal muscle generates pressure stimuli to intramuscular tissues. However, the effects of pressure stimuli, other than those created by electricity or nerve impulse, on physiological and biochemical responses in skeletal muscles are unknown. The purpose of this study is to examine the effects of a pure pressure stimulus on metabolic responses in a skeletal muscle cell line. Atmospheric pressure was applied to L6 myoblasts using an original apparatus. Succinate dehydrogenase (SDH) activity was evaluated by colorimetric assay using tetrazolium monosodium salt. The amounts of 2-deoxy-[ 3 H]glucose uptake and lactate release were measured. SDH activity was 2.6-to 2.9-fold higher in pressurized L6 cells than in nonpressurized L6 cells (P Ͻ 0.01), and 2-deoxy-[ 3 H]glucose uptake was 2.2-fold higher (P Ͻ 0.001). In addition, the amount of released lactate decreased from 6.8 to 3.7 mol/dish when pressure was applied (P Ͻ 0.001). In contrast, the intracellular lactate contents of the pressurized cells were higher than those of nonpressurized cells (P Ͻ 0.01). However, the total amount of released lactate and intracellular lactate was lower in the pressurized cells than in nonpressurized cells. These findings demonstrate that a pure pressure stimulus enhances aerobic metabolism in L6 skeletal muscle cells and raise the possibility that elevated intramuscular pressure during muscle activity may be an important factor in stimulating oxidative metabolic responses in skeletal muscles. mechanical pressure; aerobic metabolism; lactate; glucose uptake WHEN A MUSCLE CONTRACTS, it not only receives electrical stimulation but is also subjected to mechanical forces. The mechanical forces to skeletal muscles are classified into two components: stretching and intramuscular pressure. The former stimulus is developed during elongation of muscle length by external-strain force. On the other hand, intramuscular pressure is generated by contraction (i.e., force production) of the pressure-applied muscle itself, independent of alterations in muscle length (1). The effects of stretching stimuli on metabolism, intracellular signal events, and gene expression in skeletal muscle tissues or cells have been shown (3,6,9,15,16). In those studies, passive stretching (i.e., unrelated to innervation) caused glucose uptake in isolated muscles and cultured muscle cells (6,9,16). On the basis of those reports, it appears that skeletal muscle is sensitive to mechanical forces independent of electrical stimuli and humoral factors.With regard to intramuscular pressure, Ballard et al.(1) demonstrated that the intramuscular pressures at concentric contraction during walking and running were ϳ180 and 270 mmHg, respectively. However, very little is known about the effects of a pressure stimulus as a component of mechanical forces during contraction on the physiological and biochemical responses of skeletal muscles. On the basis of the intensity of the intramuscular pressure reported by Ballard et al. and the fact that a pressure stimulus i...

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Section: Methodssupporting

confidence: 74%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts

Morita¹,

Iizuka²,

Okita³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

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“…In the SOL and GAS, for example, peak values of up to 330-500 mbar were found (Sadamoto et al, 1983;Aratow et al, 1993;Ballard et al, 1998). However, the highest pressure values were determined in the thigh musculature.…”

Section: Comparison With Literaturementioning

confidence: 94%

Intermuscular pressure between synergistic muscles correlates with muscle force

Reinhardt

Siebert

Leichsenring

et al. 2016

Journal of Experimental Biology

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The purpose of the study was to examine the relationship between muscle force generated during isometric contractions (i.e. at a constant muscle-tendon unit length) and the intermuscular (between adjacent muscles) pressure in synergistic muscles. Therefore, the pressure at the contact area of the gastrocnemius and plantaris muscle was measured synchronously to the force of the whole calf musculature in the rabbit species Oryctolagus cuniculus. Similar results were obtained when using a conductive pressure sensor, or a fibre-optic pressure transducer connected to a waterfilled balloon. Both methods revealed a strong linear relationship between force and pressure in the ascending limb of the force-length relationship. The shape of the measured force-time and pressuretime traces was almost identical for each contraction (r=0.97). Intermuscular pressure ranged between 100 and 700 mbar (70,000 Pa) for forces up to 287 N. These pressures are similar to previous (intramuscular) recordings within skeletal muscles of different vertebrate species. Furthermore, our results suggest that the rise in intermuscular pressure during contraction may reduce the force production in muscle packages (compartments).

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“…In addition, during dynamic exercise, IMP varies rhythmically in the active muscles, increasing only during the contraction phase (Ballard et al, 1998). Thus, mechanical stimuli should have been augmented rhythmically during VOL and PAS in the enhanced IMP trial.…”

Section: Limitationsmentioning

confidence: 99%

The Effect of External Cuff Pressure on Initial Exercise Hyperpnea

Hotta

Yamamoto

Ishida

2009

J Physiol Anthropol

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The purpose of this study was to investigate the effect of an increase in intramuscular pressure on ventilatory response at the onset of exercise. Seven subjects participated in this study. We measured ventilatory responses to a 20-s singlearm extension-flexion exercise and passive movement. Each subject performed two kinds of exercise and passive movement in random order: in one, the exercising arm was encircled with a deflated cuff placed around the upper arm; in the other, the exercising arm was compressed by a cuff placed around the upper arm, which was inflated to 25 mmHg. We found that neither ventilatory response during exercise nor during passive movement was significantly changed even though the cuff compressed the arm. In conclusion, the increased intramuscular pressure caused by the 25-mmHg pressure of the cuff did not have a significant influence on ventilatory response at the onset of exercise.

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Leg intramuscular pressures during locomotion in humans

Cited by 63 publications

References 24 publications

Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts

Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts

Intermuscular pressure between synergistic muscles correlates with muscle force

The Effect of External Cuff Pressure on Initial Exercise Hyperpnea

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