Leg Blood Pressure Measured in Orthostatic Posture Is Associated With Left Ventricular Mass in Normotensive Subjects

Gemignani, Tiago; Matos‐Souza, José R.; Franchini, Kleber G.; Nadruz, Wilson

doi:10.1038/ajh.2012.101

Cited by 12 publications

(14 citation statements)

References 27 publications

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“…Ankle BP is correlated with arm BP and the augmentation of central BP [15]. Elevated ankle BP was demonstrated as a risk for left ventricular hypertrophy and arterial stiffness, as well as a predictor for future dementia and cardio-cerebrovascular morbidity and mortality [9]–[11].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have demonstrated that ankle BP is a useful BP index. A study showed that the leg BP in orthostatic posture is associated with left ventricular mass in normotensive subjects [9]. Furthermore, increased ankle BP is a marker of arterial stiffness or subclinical atherosclerosis, and an independent risk for future dementia, cardio-cerebrovascular morbidity and mortality [10],[11].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence and Influence Factors of Inter-Ankle Systolic Blood Pressure Difference in Community Population

Tao²,

Zhou³

et al. 2013

PLoS ONE

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AimThe aim of this study was to investigate the prevalence of interankle systolic blood pressure difference (sIAND) and its influencing factors in community population.MethodsThis study included 2849 (65.1±9.4 y) subjects. Blood pressure (BPs) of four limbs was simultaneously measured with 4 electronic sphygmomanometers after 10 min rest in supine position. The difference of systolic BP (SBP) between two ankles was calculated as DETASBP. The criterion for abnormal sIAND was ≥10 mmHg of absolute DeltaSBP, in which the criterion for 1o sIAND was 10–19 mmHg and for 2o sIAND was ≥20 mmHg. Age, gender, smoking, hypertension, family histories of hypertension and diabetes were recorded. Fasting blood glucose and lipids, circumference of hip and waist, and body mass index (BMI) were measured.ResultsThe SBP was higher in the right ankle than in the left ankle (158.9±21.8 vs 157.3±21.6 mmHg, P<0.05) and mean DeltaSBP was 6.08±6.26 mmHg. Similar difference was found in both genders. The prevalence of abnormal was 18.5%, in which, the prevalence 1o sIAND was 15.3% and that of 2o sIAND was 3.1%. Multivariate regression analysis showed that age, waist circumference and blood glucose level were the positive factors for DeltaSBP. The normal upper limit for DeltaSBP was 16.7 mmHg in this population, the prevalence of sIAND by≥16 mmHg was 5.8%.ConclusionAging, hypertension, obesity and abnormal glucose metabolism are positive factors for inter-ankle SBP difference.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prevalence and Influence Factors of Inter-Ankle Systolic Blood Pressure Difference in Community Population

Tao²,

Zhou³

et al. 2013

PLoS ONE

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“…Ankle blood pressure (BP) is used more frequently in clinical practice as it could be easily taken using an electronic BP device [ 1 – 4 ]. Previously, ankle BP was mainly used for calculating ankle-brachial index (ABI) [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, ankle BP was mainly used for calculating ankle-brachial index (ABI) [ 5 , 6 ]. Although ankle BP has been demonstrated a predictor for subclinical atherosclerosis, cardio-cerebrovascular morbidity and mortality [ 2 – 4 ], the understanding on ankle BP per se is insufficient at present. For example, the normal range of ankle BP is still uncertain, although one study considered >175 mmHg as elevated ankle systolic BP (SBP) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Valuation of Normal Range of Ankle Systolic Blood Pressure in Subjects with Normal Arm Systolic Blood Pressure

Gong

Cao

et al. 2015

PLoS ONE

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SubjectThis study aimed to establish a normal range for ankle systolic blood pressure (SBP).MethodsA total of 948 subjects who had normal brachial SBP (90-139 mmHg) at investigation were enrolled. Supine BP of four limbs was simultaneously measured using four automatic BP measurement devices. The ankle-arm difference (An-a) on SBP of both sides was calculated. Two methods were used for establishing normal range of ankle SBP: the 99% method was decided on the 99% reference range of actual ankle BP, and the An-a method was the sum of An-a and the low or up limits of normal arm SBP (90–139mmHg).ResultsWhether in the right or left side, the ankle SBP was significantly higher than the arm SBP (right: 137.1±16.9 vs 119.7±11.4 mmHg, P<0.05). Based on the 99% method, the normal range of ankle SBP was 94~181 mmHg for the total population, 84~166 mmHg for the young (18–44 y), 107~176 mmHg for the middle-aged(45–59 y) and 113~179 mmHg for the elderly (≥60y) group. As the An-a on SBP was 13mmHg in the young group and 20mmHg in both middle-aged and elderly groups, the normal range of ankle SBP on the An-a method was 103–153 mmHg for young and 110–160 mmHg for middle-elderly subjects.ConclusionA primary reference for normal ankle SBP was suggested as 100-165 mmHg in the young and 110-170 mmHg in the middle-elderly subjects.

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“… 2011 ; Gemignani et al. 2012 ). In contrast, extramural pressure follows the hydrostatic factor only very incompletely, at least in the lower limb (Pfeffer et al.…”

Section: Discussionmentioning

confidence: 99%

Impact of body tilt on the central aortic pressure pulse

et al. 2015

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The present work was undertaken to investigate, in young healthy volunteers, the relationships between the forward propagation times of arterial pressure waves and the timing of reflected waves observable on the aortic pulse, in the course of rapid changes in body position. 20 young healthy subjects, 10 men, and 10 women, were examined on a tilt table at two different tilt angles, −10° (Head-down) and + 45° (Head-up). In each position, carotid-femoral (Tcf) and carotid-tibial forward propagation times (Tct) were measured with the Complior device. In each position also, the central aortic pressure pulse was recorded with radial tonometry, using the SphygmoCor device and a generalized transfer function, so as to evaluate the timing of reflected waves reaching the aorta in systole (onset of systolic reflected wave, sT1r) and diastole (mean transit time of diastolic reflected wave, dMTT). The position shift from Head-up to Head-down caused a massive increase in both Tct (women from 130 ± 10 to 185 ± 18 msec P < 0.001, men from 136 ± 9 to 204 ± 18 msec P < 0.001) and dMTT (women from 364 ± 35 to 499 ± 33 msec P < 0.001, men from 406 ± 22 to 553 ± 21 msec P < 0.001). Mixed model regression showed that the changes in Tct and dMTT observed between Head-up and Head-down were tightly coupled (regression coefficient 2.1, 95% confidence interval 1.9–2.3, P < 0.001). These results strongly suggest that the diastolic waves observed on central aortic pulses reconstructed from radial tonometric correspond at least in part to reflections generated in the lower limbs.

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Leg Blood Pressure Measured in Orthostatic Posture Is Associated With Left Ventricular Mass in Normotensive Subjects

Abstract: Orthostatic leg BP is independently associated with the cardiac structure in normotensive subjects.

Cited by 12 publications

References 27 publications

The Prevalence and Influence Factors of Inter-Ankle Systolic Blood Pressure Difference in Community Population

The Prevalence and Influence Factors of Inter-Ankle Systolic Blood Pressure Difference in Community Population

Valuation of Normal Range of Ankle Systolic Blood Pressure in Subjects with Normal Arm Systolic Blood Pressure

Impact of body tilt on the central aortic pressure pulse

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