Left ventricular volume regulation in heart failure with preserved ejection fraction

Kerkhof, Peter L. M.; Kresh, J. Yasha; Li, John K.‐J.; Heyndrickx, Guy R.

doi:10.1002/phy2.77

Cited by 19 publications

(72 citation statements)

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“…We pinpoint a problem inherent to the use of metrics such as EF, FS, FAC, and other ratios commonly applied in cardiology, e.g. the ventriculo-arterial coupling index [1,5]. Unfortunately, the scope of this pitfall is hard to assess, as the findings depend on the values for ESV(i) and EDV(i) in each individual.…”

Section: What Is Ejection Fraction?mentioning

confidence: 97%

“…Also, 197 patients (67 women) with heart failure (HF), and multiple data series on a single heart transplant patient were analyzed. Data on LV volume were collected between 2000 and 2009 at the Cardiovascular Center in Aalst, Belgium, as described in detail before [5]. Briefly, biplane ventriculograms are recorded using a radiographic contrast agent.…”

Section: Description Of Patientsmentioning

confidence: 99%

“…1) is reflected by the coordinates {EDVi,ESVi}. The prevailing value of EF can be visualized in the VRG [3][4][5], as further explained in the Supplement. This exercise adds information to the metric EF, and in fact demonstrates that the EFC (or indexed EFCi when BSA is applied) is the inseparable partner of EF.…”

Section: Graphical Analysis In the Volume Domainmentioning

confidence: 99%

“…In practice, EF can be reformulated as a function of ESV(i), using a few population based constants [1][2][3][4][5]. In contrast, the EFC depends on ESV(i) and (mostly on) EDV(i) (eq.…”

Section: Determinants Of Ef and Efcmentioning

confidence: 99%

“…Critical remarks concerning the exclusive use of EF have been voiced as early as 1965, actually barely after its launch, as reviewed elsewhere [5]. Recently, further cautious comments have accumulated [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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The Pythagorean theorem reveals the inherent companion of cardiac ejection fraction

Kerkhof¹,

Merillon

Yoo

et al. 2018

International Journal of Cardiology

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Section: What Is Ejection Fraction?mentioning

confidence: 97%

Section: Description Of Patientsmentioning

confidence: 99%

Section: Graphical Analysis In the Volume Domainmentioning

confidence: 99%

“…In practice, EF can be reformulated as a function of ESV(i), using a few population based constants [1][2][3][4][5]. In contrast, the EFC depends on ESV(i) and (mostly on) EDV(i) (eq.…”

Section: Determinants Of Ef and Efcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Pythagorean theorem reveals the inherent companion of cardiac ejection fraction

Kerkhof¹,

Merillon

Yoo

et al. 2018

International Journal of Cardiology

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Heart Function Analysis in Cardiac Patients with Focus on Sex-Specific Aspects

Kerkhof¹,

Peace

Heyndrickx

et al. 2018

Advances in Experimental Medicine and Biology

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Cardiac function is best described by investigating the pressure-volume relationships. This information permits description in terms of the ventricular volume regulation graph (VRG), estimation of systolic elastance, evaluation of lusitropic properties, and assessment of ventriculo-arterial coupling. Current techniques yield noninvasive determination of cardiac compartmental volumes, along with systolic/diastolic arterial pressure, while ventricular end-diastolic pressure can be inferred from an echocardiography-based surrogate measure. Ventricular volume is known to vary with age, as well as to be affected by intrinsic cardiac disease and abnormalities of the vascular system. Moreover, 35 years ago it has been shown in healthy adults that left ventricular volume is significantly smaller in women compared to men. This important observation has serious implications for several metrics which are routinely used in clinical practice, e.g., ejection fraction. The remarkable difference between ventricular size in men and women is also a powerful starting point for the study of aging and the investigation of interventions such as exercise. In this review we evaluate sex-specific characteristics of the VRG and the implications for various cardiac patient populations, during basal conditions and intervention such as exercise.

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Sex- and Age-Related Reference Values in Cardiology, with Annotations and Guidelines for Interpretation

Kerkhof¹,

Peace

Macfarlane

2018

Advances in Experimental Medicine and Biology

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The definition of "abnormal" in clinical sciences is often based on so-called reference values which point to a range that experts by some sort of consensus consider as normal when looking at biological variables. Such a level is commonly calculated by taking (twice) the standard deviation from the mean, or considering certain percentiles. The suspicion or even confirmation of a disease is then established by demonstrating that the value measured exceeds the upper or lower reference value. As is often the case, the measurement accuracy may depend on the conditions and specific method employed to collect and analyze data. This implies that, for example, data assessed by 2D echocardiography possibly differ from those obtained by MRI and therefore require modality-specific reference values. In this review we summarize reference values for the electrocardiogram, cardiac compartmental volumes, and arterial vessel size in males and females for various age groups. These values may further depend on other variables such as body size, physical training status, and ethnicity. Additional variables relevant for cardiology such as those referring to the microcirculation and biomarkers are only mentioned with reference to the pertinent literature. In general, the sex- and age-specific differences observed are often remarkable and warrant consideration in clinical practice and basic biomedical sciences.

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Left ventricular volume regulation in heart failure with preserved ejection fraction

Abstract: On page 3, the text following equation (2) is incorrectly shown as:This text should appear as follows:The publisher apologizes for this oversight.

Cited by 19 publications

References 0 publications

The Pythagorean theorem reveals the inherent companion of cardiac ejection fraction

The Pythagorean theorem reveals the inherent companion of cardiac ejection fraction

Heart Function Analysis in Cardiac Patients with Focus on Sex-Specific Aspects

Sex- and Age-Related Reference Values in Cardiology, with Annotations and Guidelines for Interpretation

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