Left ventricular stroke volume index following transcatheter aortic valve replacement is an early predictor of 1‐year survival

Annamalai, Shiva; Koethe, Benjamin; Simsolo, Eli; Huang, Duohui; Connors, Ann; Resor, Charles D.; Weintraub, Andrew; Pandian, Natesa G.; Downey, Brian C.; Patel, Ayan R.; Wessler, Benjamin S.

doi:10.1002/clc.23937

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, various cardiac function parameters such as the left ventricular stroke volume index or the ejection fraction have been studied to predict postoperative mortality rates (27,28). However, not all patients are examined for these indicators, and different hospitals may have different standards depending on the equipment and/or operator.…”

Section: Discussionmentioning

confidence: 99%

Preoperative inflammatory markers predict postoperative clinical outcomes in patients undergoing heart valve surgery: A large-sample retrospective study

Tian

Jiang²,

Duan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionPreoperative inflammation affects the postoperative outcomes of patients undergoing heart valve surgery. This study aimed to explore the role and predictive effects of preoperative inflammation on the primary outcomes after valvular cardiac surgery.MethodsThis retrospective study utilized a medical recording system to screen 5075 patients who underwent heart valve surgery. Data on the C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and neutrophil-to-lymphocyte ratio (NLR) before heart valve surgery were collected from the hospital’s medical system. Postoperative hepatic insufficiency, acute kidney injury, heart failure, and myocardial damage were assessed using blood indicators. Patients with and without prolonged mechanical ventilation, extended intensive care unit stays, prolonged hospital stays, and death within 30 days after surgery (considered the primary outcome in this study) were compared. Group comparisons, receiver operating characteristic (ROC) curve analyses, and logistic analyses were performed to determine the associations between preoperative inflammation and outcomes after heart valve surgery.ResultsA total of 3249 patients were included in the analysis. Significant differences in CRP level, ESR, and NLR were found between patients with and without postoperative adverse outcomes. ROC analysis showed that CRP levels >5 mg/L effectively predicted postoperative heart failure, and NLR >3.5 had a good predictive effect on all-cause mortality within 30 days after surgery. Patients with CRP levels >5 mg/L had a higher incidence of postoperative heart failure than other patients (20.7% vs. 12.6%, P<0.001), with a relative risk of 1.447 (95% confidence interval: 1.155–1.814). Patients with NLR >3.5 had a higher incidence of death within 30 days after surgery (5.3% vs. 1.2%, P<0.001), with a relative risk of 3.236 (95% confidence interval: 1.773–5.906).ConclusionPreoperative inflammation can affect postoperative outcomes in patients undergoing heart valve surgery. CRP level >5 mg/L and NLR >3.5 can effectively predict postoperative heart failure and death within 30 days after surgery, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative inflammatory markers predict postoperative clinical outcomes in patients undergoing heart valve surgery: A large-sample retrospective study

Tian

Jiang²,

Duan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Left ventricular stroke volume index following transcatheter aortic valve replacement is an early predictor of 1‐year survival

Annamalai

Koethe

Simsolo

et al. 2022

Clinical Cardiology

View full text Add to dashboard Cite

Background Adverse cardiac events are common following transcatheter aortic valve replacement (TAVR). Our aim was to investigate the low left ventricular stroke volume index (LVSVI) 30 days after TAVR as an early echocardiographic marker of survival. Hypothesis Steady‐state (30‐day) LVSVI after TAVR is associated with 1‐year mortality. Methods A single‐center retrospective analysis of all patients undergoing TAVR from 2017 to 2019. Baseline and 30‐day post‐TAVR echocardiographic LVSVI were calculated. Patients were stratified by pre‐TAVR transaortic gradient, surgical risk, and change in transvalvular flow following TAVR. Results This analysis focuses on 238 patients treated with TAVR. The 1‐year mortality rate was 9% and 124 (52%) patients had normal flow post‐TAVR. Of those with pre‐TAVR low flow, 67% of patients did not normalize LVSVI at 30 days. The 30‐day normal flow was associated with lower 1‐year mortality when compared to low flow (4% vs. 14%, p = .007). This association remained significant after adjusting for known predictors of risk (adjusted odds ratio [OR] of 3.45, 95% confidence interval: 1.02–11.63 [per 1 ml/m 2 decrease], p = .046). Normalized transvalvular flow following TAVR was associated with reduced mortality (8%) when compared to those with persistent (15%) or new‐onset low flow (12%) ( p = .01). Conclusions LVSVI at 30 days following TAVR is an early echocardiographic predictor of 1‐year mortality and identifies patients with worse intermediate outcomes. More work is needed to understand if this short‐term imaging marker might represent a novel therapeutic target.

show abstract

Left ventricular stroke volume index following transcatheter aortic valve replacement is an early predictor of 1‐year survival

Cited by 2 publications

References 20 publications

Preoperative inflammatory markers predict postoperative clinical outcomes in patients undergoing heart valve surgery: A large-sample retrospective study

Preoperative inflammatory markers predict postoperative clinical outcomes in patients undergoing heart valve surgery: A large-sample retrospective study

Left ventricular stroke volume index following transcatheter aortic valve replacement is an early predictor of 1‐year survival

Contact Info

Product

Resources

About