Left ventricular non-compaction cardiomyopathy

Towbin, Jeffrey A.; Lorts, Angela; Jefferies, John L.

doi:10.1016/s0140-6736(14)61282-4

Cited by 433 publications

(425 citation statements)

References 122 publications

Supporting

Mentioning

362

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the use of gadolinium contrast in the LGE technique also eft ventricular non-compaction (LVNC) is a genetic cardiomyopathy characterized by prominent trabeculations and deep intertrabecular recesses in the left ventricle. 1- 3 The major clinical presentations of LVNC include progressive dysfunction, arrhythmia, and sudden death, 1-3 which have been found to be associated with myocardial fibrosis. [4][5][6] Recent studies have shown that fibrosis is an effective indicator of the severity and prognosis of LVNC.…”

mentioning

confidence: 99%

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Zhou

Xue

Fang

et al. 2016

Circ J

View full text Add to dashboard Cite

Background: Native T1 mapping is an emerging cardiac magnetic resonance technique for quantitative evaluation of cardiomyopathies. This study aimed to investigate the usefulness of native T1 mapping in characterizing myocardial abnormalities in left ventricular non-compaction (LVNC) by comparing it with late gadolinium enhancement (LGE). Methods and Results:The study group of 31 LVNC patients and 8 normal controls underwent cardiovascular magnetic resonance to acquire the native T1 maps and LGE images. Of the 31 LVNC patients, 14 had LGE. The mean native T1 value of the normal controls, LGE(−) and LGE(+) patients was 1,098.8±40.8 ms, 1140.6±32.8 ms, and 1181.4±53.7 ms, respectively. Significant differences were found in native T1 between any 2 groups (F=9.74, P<0.001). In discriminating the presence of LGE in LVNC patients, the odds ratio and corresponding 95% confidence interval (CI) of native T1 were, respectively, 2.966 (95% CI: 1.123-7.835, P=0.028) and 4.348 (95% CI: 1.155-16.363, P=0.030) before and after adjusting for confounding factors with an increment of 1 standard deviation. Conclusions:The finding that LGE(−) patients had elevated native T1 compared with normal controls suggested native T1 mapping can be used earlier than LGE imaging to detect myocardial fibrosis in LVNC patients. Furthermore, higher native T1 values in LGE(+) patients than in the LGE(−) group suggested native T1 mapping is more sensitive than LGE imaging for identifying myocardial fibrosis in LVNC patients. 1211 Native T1 Mapping Evaluates Myocardium Abnormality factors for cardiac disease (diabetes mellitus, hypertension, and smoking) were enrolled as normal controls. The age and sex of the normal volunteers were matched with the LVNC patient group. Clinical information was collected from the medical record. The study protocol was approved by the local Institutional review board and written informed consent was given by all subjects. CMR ProtocolThe CMR imaging was performed with a 3.0-T MR system (Achieva TX, Philips Healthcare, Best, The Netherlands) using a 32-channel phased array heart coil (InVivo, Gainesville, FL, USA). The cine, phase-sensitive inversion recovery (PSIR), and modified look-locker inversion recovery (MOLLI) image sequences were acquired. 16 The ECG-gated balanced steadystate free precession (bSSFP) cine images of the long-and short-axis (SAX) images covering the entire LV were acquired with the following parameters: TR/TE 2.7/1.3 ms with 30 heart phases; voxel size 1.8×1.5×8.0 mm 3 ; slice thickness 8 mm; and slice spacing 2 mm. The PSIR sequence was acquired 15±5 min after the injection of 0.2 mmol/kg of gadolinium-DTPA (Magnetism, Bayer Schering Pharma, Guangzhou, China) with flow rate of 3 ml/s and 20 ml saline for flushing. The LGE images were obtained during mid-diastole in the same SAX orientations as cine, covering the whole LV, with the following imaging

show abstract

mentioning

confidence: 99%

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Zhou

Xue

Fang

et al. 2016

Circ J

View full text Add to dashboard Cite

show abstract

“…Vor allem die kardialen Strukturproteine zeigen eine große Überlappung mit den Kardiomyopathien. [23].…”

Section: Nicht-syndromale Strukturelle Herzfehlerunclassified

“…Mittels genetischer Diagnostik lässt sich mit 35-40 % im Vergleich zu AHF ein deutlich höherer Prozentsatz an Mutationen bei den betroffenen Personen mit LVNC identifizieren [23,25,29]. Dies könnte, trotz der großen Vielfalt an unterschiedlichen Genen, an einem gemeinsamen Entstehungsmechanismus liegen, der auf unterschiedliche Art und Weise während der Entwicklung gestört wird.…”

Section: Nicht-syndromale Strukturelle Herzfehlerunclassified

Genetik der angeborenen Herzfehler

Kahlert

Hoff

Hitz

2017

Medizinische Genetik

View full text Add to dashboard Cite

show abstract

“…The introduction of two-dimensional echocardiography facilitated the evaluation of left ventricle (LV) anatomy and continuously increased the number of cases diagnosed. In 1984 Engberding described the presence of 'sinusoids' within the LV, but it was not until 1990 that the first diagnostic echocardiographic criteria of LVNC were proposed and terminology was established (2,3).…”

Section: Introductionmentioning

confidence: 99%

Non-compaction cardiomyopathy – brief review

Mirea¹,

Berceanu²,

Constantin³

et al. 2017

J Mind Med Sci.

View full text Add to dashboard Cite

Left ventricular non-compaction cardiomyopathy is a genetic disorder characterized by the presence of two myocardial layers with numerous prominent trabeculations and deep inter-trabecular recesses that communicate with the ventricular cavity. The diagnosis is often challenging because excessive trabeculations may also be a normal finding in performance athletes and black people.Echocardiography is the gold standard for diagnosis of this condition, but other useful diagnostic techniques may include cardiac magnetic resonance imaging, computed tomography, and contrast ventriculography. Moreover, newer echocardiographic methods such as three-dimensional imaging and speckle tracking analysis promise to improve the diagnosis of left ventricular non-compaction cardiomyopathy. The purpose of this paper is to review the pathogenesis, diagnosis, and management of this disease.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks.

show abstract

Left ventricular non-compaction cardiomyopathy

Cited by 433 publications

References 122 publications

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Genetik der angeborenen Herzfehler

Non-compaction cardiomyopathy – brief review

Contact Info

Product

Resources

About

Left ventricular non-compaction cardiomyopathy

Cited by 433 publications

References 122 publications

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients – A Comparison With Late Gadolinium Enhancement –

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients – A Comparison With Late Gadolinium Enhancement –

Genetik der angeborenen Herzfehler

Non-compaction cardiomyopathy – brief review

Contact Info

Product

Resources

About

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –