Non-compaction cardiomyopathy – brief review

Mirea, Oana; Berceanu, Mihaela; Constantin, Anca; Manescu, M; Târtea, Georgică Costinel; Donoiu, I; Militaru, Constantin; Istrătoaie, Octavian

doi:10.22543/7674.42.p115124

Cited by 4 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Major adverse cardiac events, mainly heart failure, ventricular arrhythmias, and sudden death in this setting, as in other forms of cardiomyopathy, including DCM, are strongly (inversely proportionally) correlated with LVEF and myocardial fibrosis upon LGE [7]. The diagnosis of cardiomyopathy by non-compaction is preferably echocardiographic, but there are uncertain situations in which a multimodal imaging approach is necessary, incorporating echocardiography, nuclear magnetic resonance, computed tomography, or ventriculography [8]. In these situations, CMR is the preferred technique.…”

Section: Discussionmentioning

confidence: 99%

The Value of Multimodal Imaging in Early Phenotyping of Cardiomyopathies: A Family Case Report

Iovanescu

Florescu²,

Militaru

et al. 2023

JPM

Self Cite

View full text Add to dashboard Cite

Cardiomyopathies are structural and functional myocardial disorders that are not caused by other specific conditions such as coronary artery disease, arterial hypertension, valvular disease or congenital heart diseases. They are grouped into specific morphological and functional phenotypes, and sub-classified into familial and non-familial forms, with the dilated phenotype being the most frequent. However, there are many overlapping features between these phenotypes, complicating the diagnosis and management of patients. We report here the case of three related patients with different types of cardiomyopathies, emphasizing the importance of a multimodal approach to diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

The Value of Multimodal Imaging in Early Phenotyping of Cardiomyopathies: A Family Case Report

Iovanescu

Florescu²,

Militaru

et al. 2023

JPM

Self Cite

View full text Add to dashboard Cite

show abstract

“…As a consequence of ischemia, fibrosis may expand progressively and will ultimately determine left ventricular systolic function depression which may provoke electrical inhomogeneity and micro-reentry resulting in ventricular arrhythmias and SCD [17]. It is known that the autonomic tone, baroreflex sensitivity, and mechanistic properties of the myocardium should be intact for the regulation of HRT in response to a minor fluctuation in blood pressure; however, fibrosis and left ventricular dysfunction may diminish the vagal activity and cause decreased HRT or disappearance of HRT after VPBs in patients with NC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Heart Rate Turbulence Parameters in Patients with Noncompaction Cardiomyopathy

Buğan

Çekirdekçi

2019

Cardiology

View full text Add to dashboard Cite

Background: Noncompaction cardiomyopathy (NC) is a rare congenital heart disease characterized by progressive heart failure and life-threatening arrhythmias. Heart rate turbulence (HRT) has been defined as a noninvasive prognostic method to reveal the cardiac death risk in high-risk patients. Objectives: We aimed to assess the cardiac autonomic functions and their relations to the mortality in NC patients. Methods: A total of 60 NC patients and 70 healthy controls were included in this study. All participants underwent 24-h Holter recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of NN intervals of all normal beats (SDNN) and mean RR interval. Results: NC patients had higher levels of TO than the control group (0.43 ± 4.66% vs. –1.82 ± 2.19%, p = 0.024), but the TS levels of NC patients were lower than those of the control group (3.43 ± 3.28 vs. 4.94 ± 2.86 ms/RR, p = 0.024). Thirteen patients died during follow-up (mean 83.3 ± 32.5 months). TS was the strongest univariate mortality predictor (hazard ratio 10.01 [95% CI 2.22–42.52]; p = 0.004) in univariate Cox regression analysis. In multivariate analysis, LVEF ≤0.40 and TS ≤2.5 ms/RR interval were the only independent predictors of mortality (hazard ratio 5.29; p = 0.004, hazard ratio 13.45; p = 0.001, respectively). Conclusions: Patients with NC showed abnormal HRV and HRT parameters when compared to healthy subjects. Furthermore, impaired HRT reaction in NC is an independent predictor of mortality.

show abstract

“…However, clinically manifest DHIS will develop only in 8% of patients as compensatory mechanisms (arterial collaterals and distal vasodilatation) improve tissue perfusion (3). Other studies have shown that a surgical procedure is necessary in 1,7% -9% of patients (20)(21)(22). If these compensatory mechanisms are altered by the presence of arterial atherosclerosis, arterial stenosis, vascular calcification secondary to Chronic Kidney Disease or peripheral neuropathy, then ischemia occurs and clinical signs appear (23).…”

Section: Discussionmentioning

confidence: 99%

Stenotic ligature: a simple technique for managing distal hypoperfusion ischemic syndrome following arteriovenous fistulas

Roata¹,

Moroşanu²,

Makkai-Popa³

et al. 2018

J Clin Invest Surg.

View full text Add to dashboard Cite

Introduction. Distal Hypoperfusion Ischemic Syndrome (DHIS) is a multifactorial debilitating condition causing peripheral ischemia and potentially tissue necrosis. In an effort to further refine its surgical treatment we aim to describe a modified, simple and reliable technique for managing DHIS in patients with arteriovenous fistulas.Materials and Methods. Twenty-nine consecutive patients with DHIS operated by a single surgical team over a period of 7 years were included in the study. All patients underwent the same surgical technique: stenotic ligature. Outcomes were analyzed clinically and the effectiveness of the procedure was proven using McNemar test. Clinical variables were statistically analyzed in SPSS 17.0 for Windows.Results. The technique we used consists in performing a stenosing ligature on the vein, using a 0-silk suture, and adjusting the suture in order to achieve either a radial pulse or capillary pulse, while maintaining a good thrill at palpation of the vein. The procedure was successful in 83% of patients proved by immediate symptomatic relief. Paired data analysis showed significant decrease of all symptoms: cold extremity (p=0,021), paraesthesia (p<0,001), pain (p<0,001). History of coronary artery disease, arteriopathy or the absence of radial pulse is statistically correlated with an increased risk of developing DHIS.Conclusions. Stenotic ligature is a simple, cheap and reliable technique for managing DHIS with lower septic risks which can be easily performed under local anesthesia.

show abstract

Non-compaction cardiomyopathy – brief review

Cited by 4 publications

References 33 publications

The Value of Multimodal Imaging in Early Phenotyping of Cardiomyopathies: A Family Case Report

The Value of Multimodal Imaging in Early Phenotyping of Cardiomyopathies: A Family Case Report

Prognostic Significance of Heart Rate Turbulence Parameters in Patients with Noncompaction Cardiomyopathy

Stenotic ligature: a simple technique for managing distal hypoperfusion ischemic syndrome following arteriovenous fistulas

Contact Info

Product

Resources

About