Left Ventricular Myxoma Causing Sudden Death

Kitchin, Patricia Lee; Benson, Paul

doi:10.1097/paf.0000000000000141

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…In our case, the heart was larger than the average with dilated ventricle and abnormal ventricular wall thickness. The focal myocardial fibrosis, diffused fatty infiltration and disarray of partial cardiomyocytes were observed morphologically, demonstrating that the decedent suffered from an early DCM [13,14]. Although the heart failure is the leading cause of death in DMD patients, deaths resulting from pneumonia, multi-organ failure, malnutrition, fat embolism and adrenal insufficiency cannot be ignored [4].…”

Section: Discussionmentioning

confidence: 99%

Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report

Zhang

Zhao

et al. 2017

Forensic Sciences Research

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Duchenne muscular dystrophy (DMD) is one of the most common and severest muscular dystrophies. Although it can be a cause of death when associated with cardiac muscle and/or respiratory muscles, no cases of sudden deaths in the setting of undiagnosed DMD with cardiac involvement have been reported in the literatures. Previous studies showed that N-terminal-proBNP (NT-proBNP) was a robust laboratory biomarker to diagnose and monitor cardiac failure in clinical situations, suggesting that it may be used as an auxiliary indicator for diagnosis on left ventricular dysfunction in sudden cardiac deaths in forensic settings. Here, we reported a case of 29-year-old man who died suddenly. Autopsy revealed that muscles of the body were almost replaced by fatty and fibrotic tissues. The heart was enlarged with disarray and degeneration of cardiomyocytes in cardiac muscle. Total absence of dystrophin was detected by immunohistochemical staining, which confirmed DMD. Postmortem biochemical test of pericardial fluid revealed a high level of NT-proBNP, indicating dysfunction of the left ventricle before death. The cause of death was certified as an early dilated cardiomyopathy (DCM)/dysfunction of the left ventricle secondary to DMD, suggesting that sudden cardiac death with cardiac dysfunction could be identified by immunohistochemical method in combination with pericardial fluid NT-proBNP determination after systemic autopsy.

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Section: Discussionmentioning

confidence: 99%

Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report

Zhang

Zhao

et al. 2017

Forensic Sciences Research

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“…Embolisms into the right coronary artery are more often described in the literature, in comparison with the left coronary artery. Patients typically present with STEMI rather than NSTEMI, but cases of sudden cardiac death have also been reported [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

The First Manifestation of a Left Atrial Myxoma as a Consequence of Multiple Left Coronary Artery Embolisms

Novák

Fila

Hlinomaz

et al. 2017

The Journal of Critical Care Medicine

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A case of multiple embolisms in the left coronary artery as a rare first manifestation of left atrial myxoma is reported. A patient with embolic myocardial infarction and congestive heart failure was treated by percutaneous aspirations and balloon dilatations. Transesophageal echocardiography disclosed a villous myxoma with high embolic potential. Surgical resection of the tumour, suturing of a patent foramen ovale suture and an annuloplasty of the dilated tricuspid annulus was performed the third day after the admission.Recovery of the documented left ventricular systolic function can be explained by resorption of myxomatous material. The patient was discharged ten days after the surgery.

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“…[ 4 ] LV myxoma is usually benign, but may lead to fatal consequences including emboli and cardiac arrhythmias resulting in sudden death. [ 5 , 6 ] Because of the deadly outcome of this disease, it is important to make a correct diagnosis. LV myxoma, which is easily misdiagnosed as LV thrombosis, has been reported in some case reports.…”

Section: Introductionmentioning

confidence: 99%

Left atrial myxoma with left ventricular myxoma diagnosed by ultrasound examination

Ji¹,

Zhang

2021

Medicine

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Rationale: Left ventricular (LV) myxoma is a rare type of benign cardiac tumor, which may result in unfavorable consequences due to embolism, arrhythmia, obstruction to the outflow tract, and other constitutional symptoms. LV myxoma can be easily misdiagnosed as LV thrombosis. Although some literatures have reported LV myxoma, the echocardiographic features of Left atrial (LA) myxoma with LV myxoma have rarely been reported till date. Here, we report case of LA myxoma with LV myxoma diagnosed by echocardiographic examination. Patient concerns: A 56-year-old male patient suffering from chest tightness and asthma for 6 months and progressive aggravation for 1 month was admitted to our hospital. Diagnosis: Echocardiographic imaging gave the suspicion of LA myxoma with LV myxoma, which was confirmed by pathology. Interventions: This patient was treated surgically. Outcomes: The patient had no postoperative complications and is currently under regular follow-up. Lessons: Echocardiography can be an effective imaging method for the evaluation of LV myxoma. The combination of echocardiography and clinical symptoms may help to make an accurate diagnosis.

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Left Ventricular Myxoma Causing Sudden Death

Cited by 9 publications

References 21 publications

Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report

Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report

The First Manifestation of a Left Atrial Myxoma as a Consequence of Multiple Left Coronary Artery Embolisms

Left atrial myxoma with left ventricular myxoma diagnosed by ultrasound examination

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