Left Ventricular Hypertrophy Phenotype in Childhood‐Onset Essential Hypertension

Gupta-Malhotra, Monesha; Hashmi, S. Shahrukh; Poffenbarger, Tim; McNiece-Redwine, Karen

doi:10.1111/jch.12708

Cited by 12 publications

(6 citation statements)

References 53 publications

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“…However, when the children were stratified into groups based on obesity and LVH status, non-obese children with LVH had significantly higher 24-h ambulatory systolic BP than did the non-obese children without LVH. In the obese children, 24-h ambulatory systolic BP was no different between those with and without LVH [52]. …”

Section: Is Weight Loss More Important Than Lowering Bp When Aiming Tmentioning

confidence: 99%

The Role of Obesity in the Development of Left Ventricular Hypertrophy Among Children and Adolescents

Brady

2015

Curr Hypertens Rep

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Both obesity and hypertension have increased substantially among children over the last several decades. At the same time, mounting evidence has pointed to the role of these and other cardiovascular disease risk factors on the development of end organ damage such as left ventricular hypertrophy in children. While traditionally thought to occur in response to an increased afterload as in systemic hypertension, evidence demonstrates that obesity is associated with left ventricular hypertrophy independent of blood pressure. Both hemodynamic and non-hemodynamic factors contribute to the pathogenesis of obesity-related left ventricular remodeling. However, more contemporary research suggests that adiposity and blood pressure have a greater effect on left ventricular geometry when present together than when present alone. Normalization of left ventricular mass in obese hypertensive individuals requires achievement of both normotension and weight loss. Additional strategies are needed to promote the cardiovascular health of children, with greater emphasis placed on obesity prevention.

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Section: Is Weight Loss More Important Than Lowering Bp When Aiming Tmentioning

confidence: 99%

The Role of Obesity in the Development of Left Ventricular Hypertrophy Among Children and Adolescents

Brady

2015

Curr Hypertens Rep

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“…Further, it is important to capture and treat this population early since cardiovascular changes can occur in the very young. We have previously reported cardiovascular endorgan damage in childhood onset EH, including left ventricular hypertrophy (9, 10), myocardial dysfunction (11, 12) and aortopathy (13). Thus, evaluation of epidemiology of childhood onset EH can help with early prevention strategies to reduce the disease burden in later life.…”

Section: Introductionmentioning

confidence: 99%

“…The investigators found factors such as gender, race, and socioeconomic status, among others, to play a role in adherence to antihypertensive therapy (14). Lastly, in order to better inform pediatricians on clinical management of their patients, one needs to study and report epidemiological findings on a chronic disease such as EH (9).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Childhood Onset Essential Hypertension

Gupta-Malhotra

Shete²,

Barratt

et al. 2018

J Hum Hypertens

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The knowledge of epidemiology of a disease is paramount in identifying preventive measures. Currently there is a paucity of literature on the epidemiologic determinants of childhood onset essential hypertension (EH). We evaluated children with EH, ascertained in a rigorous manner, in a large multiethnic population in a tertiary pediatric hypertension clinic. We enrolled children with and without EH and obtained data by in-person interview of their parents and by direct anthropometric measurements including blood pressures. A total of 148 children (76 hypertension probands, 72 control probands, and males 53%, mean age 12.2 ± 4.3 years) were enrolled. Of these 148 children, 51 pairs were matched 1:1 on ethnicity, gender and age (±2.5 years). In this study we evaluated the demographics, genetic predisposition and a variety of exposures including, socioeconomic, perinatal, lifestyle and environmental, between cases and controls. All measures were similar between cases and controls other than a significantly higher BMI (p = 0.01) and rates of obesity (p = 0.03), and a difference of near-significance in any family history of EH (p = 0.05) higher in cases compared to controls. The odds of obesity was 3.5 times higher among cases than controls. In this study, we evaluated a variety of prenatal and postnatal exposures that could potentially contributed to the EH phenotype in childhood. The findings of the study elucidate the epidemiology of EH in children and two important associated risk factors, any family history of hypertension and a higher body weight.

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“…Several mechanisms have been implicated in obesity-associated hypertension. First, obesity is characterized by hemodynamic changes due to volume overload, causing increased cardiac output, peripheral vascular resistance, and increased arterial blood pressure [80][81][82][83]. Second, high salt intake due to increased food consumption alters sodium homeostasis [84], promoting hypertension [85].…”

Section: Hypertensionmentioning

confidence: 99%

Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle

Monsalve,

Delgado-López,

Fernández-Tapia

et al. 2023

IJMS

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The study of adipose tissue has received considerable attention due to its importance not just in maintaining body energy homeostasis but also in playing a role in a number of other physiological processes. Beyond storing energy, adipose tissue is important in endocrine, immunological, and neuromodulatory functions, secreting hormones that participate in the regulation of energy homeostasis. An imbalance of these functions will generate structural and functional changes in the adipose tissue, favoring the secretion of deleterious adipocytokines that induce a pro-inflammatory state, allowing the development of metabolic and cardiovascular diseases and even some types of cancer. A common theme worldwide has been the development of professional guidelines for the control and treatment of obesity, with emphasis on hypocaloric diets and exercise. The aim of this review is to examine the pathophysiological mechanisms of obesity, considering the relationship among adipose tissue and two aspects that contribute positively or negatively to keeping a healthy body homeostasis, namely, exercise and noninfectious diseases. We conclude that the relationship of these aspects does not have homogeneous effects among individuals. Nevertheless, it is possible to establish some common mechanisms, like a decrease in pro-inflammatory markers in the case of exercise, and an increase in chronic inflammation in non-communicable diseases. An accurate diagnosis might consider the particular variables of a patient, namely their molecular profile and how it affects its metabolism, routines, and lifestyle; their underling health conditions; and probably even the constitution of their microbiome. We foresee that the development and accessibility of omics approaches and precision medicine will greatly improve the diagnosis, treatment, and successful outcomes for obese patients.

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Left Ventricular Hypertrophy Phenotype in Childhood‐Onset Essential Hypertension

Cited by 12 publications

References 53 publications

The Role of Obesity in the Development of Left Ventricular Hypertrophy Among Children and Adolescents

The Role of Obesity in the Development of Left Ventricular Hypertrophy Among Children and Adolescents

Epidemiology of Childhood Onset Essential Hypertension

Adipose Tissue, Non-Communicable Diseases, and Physical Exercise: An Imperfect Triangle

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