Left ventricular hypertrophy as a determinant of renal outcome in patients with high cardiovascular risk

Tsioufis, Costas; Kokkinos, Peter; MacManus, Chris; Thomopoulos, Costas; Faselis, Charles; Doumas, Michael; Stefanadis, Christodoulos; Papademetriou, Vasilios

doi:10.1097/hjh.0b013e32833d95fe

Cited by 45 publications

(29 citation statements)

References 32 publications

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“…LVH is considered a predictor of adverse renal outcome in patients with high cardiovascular risk [24] . Augmented LV mass index and higher LVH rates are correlated with an increase in urinary albumin excretion [25] .…”

Section: Preexisting Cardiac and Renal Damage In The Shr Closely Resementioning

confidence: 99%

“…In this review, we discuss how the aging male SHR can be a suitable animal model for the evaluation of the interaction between CI-AKI and CRS type 1 and 3. Table 1 and figure 1 show similar risk factors for CI-AKI, including hypertension, obesity, and age, shared by the SHR [17][18][19][20][21][22][23] and humans with preclinical CRS [10,18,[23][24][25][26][27][28][29] . In humans with preclinical CRS, essential hypertension acts as a risk factor for subclinical cardiac and renal damage.…”

Section: Introductionmentioning

confidence: 99%

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Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Zhang

Fallahzadeh

McCullough³

2016

Cardiorenal Med

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Background:Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged. Summary: We hypothesize that the aging male spontaneously hypertensive rat (SHR) is likely to be a suitable model. The SHR model is able to mimic risk factors for preclinical CRS that appears in the clinical setting, specifically hypertension, age, preexisting damage and dysfunction of the heart and kidney, endothelial dysfunction, increased level of reactive oxygen species, decreased level and bioavailability of nitric oxide (NO), impairment of the L -arginine-NO pathway, and insulin resistance. In the SHR, CI-AKI results in a different profile of AKI biomarkers than is seen with preexisting chronic kidney injury. Key Messages: The SHR model can be used to evaluate the interaction between CI-AKI and CRS type 1 and 3 and to verify neutrophil gelatinase-associated lipocalin (NGAL) as a reliable CI-AKI biomarker for clinical application. Further research is warranted with a large number of aging male SHRs to prove NGAL as a sensitive, specific, highly predictive, early biomarker for CI-AKI.

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Section: Preexisting Cardiac and Renal Damage In The Shr Closely Resementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Zhang

Fallahzadeh

McCullough³

2016

Cardiorenal Med

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“…Хотя эхокардиография и не лишена определенных технических ограничений, она более чувствительна, чем ЭКГ, в диагностике ГЛЖ и помогает уточнить сердечно-сосудистый и почечный риск [155][156][157]. Следовательно, эхокардиография позволяет точнее стратифицировать общий риск и выбрать схему лече-ния [158].…”

Section: эхокардиографияunclassified

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

Mancia

Fagard²,

Redón³

et al. 2014

Russ J Cardiol

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Авторы/члены рабочей группы: Giuseppe Mancia (сопредседатель; италия)*, Robert Fagard (сопредседатель; бельгия)*, Krzysztof Narkiewicz (координатор секции, Польша), Josep Redón (координатор секции; испания), Alberto Zanchetti (координатор секции, италия), Michael Böhm

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“…In hypertensive patients, LVH is independent prognosticator of the composite end point of all-cause death and cardiovascular morbidity, a major predictor for stroke (41) as well as a determinant of renal outcome in patients with high cardiovascular risk (41).…”

Section: Diagnosis Of Left Ventricular Hypertrophymentioning

confidence: 99%

How to estimate left ventricular hypertrophy in hypertensive patients

Lović¹,

Erdine²,

Çatakoğlu³

2014

Anadolu Kardiyol Derg

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Left ventricular hypertrophy (LVH) is a structural remodeling of the heart developing as a response to volume and/or pressure overload. Previous studies have shown that hypertension is not an independent factor in the development of LVH and occurrence does not depend on the length and severity of hypertension, but the role played by other comorbidities such as triglycerides, age, gender, genetics, insulin resistance, obesity, physical inactivity, increased salt intake and chronic stress. LVH develops through three phases: adaptive, compensatory, and pathological phase. Contractile dysfunction is reversible in the first two phases and irreversible in the third. According to the Framingham study, LVH develops in 15-20% of patients with mild arterial hypertension, and in 50% of patients with severe hypertension. The pathophysiology of LVH includes hypertrophy of cardiomyocytes, interstitial and perivascular fibrosis, coronary microangiopathy and macroangiopathy. Individuals with LVH have 2-4 times higher risk of having adverse CV events compared to patients without LVH. (Anadolu Kardiyol Derg 2014; 14: 389-95)

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Left ventricular hypertrophy as a determinant of renal outcome in patients with high cardiovascular risk

Abstract: Increased left ventricular mass is a predictor of subsequent kidney dysfunction and should be considered in renal risk stratification in a broad spectrum of men with high cardiovascular risk.

Cited by 45 publications

References 32 publications

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

How to estimate left ventricular hypertrophy in hypertensive patients

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