2016
DOI: 10.1159/000447542
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Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Abstract: Background:Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged. Summary: We hypo… Show more

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Cited by 10 publications
(6 citation statements)
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“…Our data supported the coexistence of cardiac and renal damage in SHR [20,23,30,[36][37][38]. Histologically, we confirmed glomerular and tubular lesions in hypertensive conditions [1,5,23].…”
Section: Discussionsupporting
confidence: 86%
See 1 more Smart Citation
“…Our data supported the coexistence of cardiac and renal damage in SHR [20,23,30,[36][37][38]. Histologically, we confirmed glomerular and tubular lesions in hypertensive conditions [1,5,23].…”
Section: Discussionsupporting
confidence: 86%
“…The SHR is a reliable model of a spontaneously developing pressure load similar to human essential hypertension; thus, it is usually recognized that the SHR represents an analog of essential hypertension in humans [21,22]. Severe hypertension arises in 100% of SHR with a systolic blood pressure of 180 mmHg or higher [23].…”
Section: Introductionmentioning
confidence: 99%
“…Myocardial dysfunction occurs prior to changes in ventricular geometry in mice with chronic kidney disease (CKD). However, many animal and clinical studies have focused on uremic cardiomyopathy in advanced CKD (type 4 and 5) or in patients on dialysis 28 , 29 , 59 .…”
Section: Discussionmentioning
confidence: 99%
“…ED often leads to lower GFR and diuretic effects, which cause fluid retention and an increased preload [ 65 ]. Human and rat studies show that ED can also lead to decreased eNOS expression and thus induce reduced expression of vasodilation factors, such as NO; abnormal endothelium-dependent vasodilation; and the onset of arteriosclerosis and calcification [ 66 , 67 ]. ED in animal is a key process involved in the development of CRS, and it plays a vital role in the connection between cardiovascular disease and CKD ( Figure 2 ) [ 68 ].…”
Section: The Role Of Raas-mediated Asymmetric Dimethylarginine (Adma) In Crsmentioning
confidence: 99%