Left ventricular flow propagation during early filling is related to wall relaxation: A color M-mode Doppler analysis

Abstract

The velocity of flow propagation during early filling seems to be highly dependent on the left ventricular relaxation rate and could be an important tool in studying diastolic function.

Diastolic Filling and Pressure Imaging: Taking Advantage of the Information in a Colour M-mode Doppler Image

“…v p is decreasing with age. Agedependency is also observed by Brun et al [47] and Mego et al [57] , reporting correlation coefficients of r= 0·61 and r= 0·59 respectively.…”

“…The higher peak E-velocity, compared to v p , is observed in vitro and in numero [42][43][44][45][46] , and in vivo [47][48][49] .…”

“…Method 1: Brun. Brun et al [47] defined v p as the slope (in m. Method 2: Duval-Moulin-Garcia. As the black-tocolour transition, as defined by Brun et al, is not always clearly visible, Duval-Moulin et al [51] and Garcia et al [30] have modified this method by considering boundaries of equal velocities, so-called isovelocity boundaries instead of black-to-colour transitions [ Fig.…”

“…Studies (Table 3) in both animals and humans during coronary angioplasty-induced ischaemia [49,51,58] , during intra-coronary dobutamine infusion [47] , before and during cardiopulmonary bypass [59] , in a mixed patient population [52] and in patients with hypertrophic cardiomyopathy [60] describe a univariate correlation of the constant of isovolumic relaxation (tau) with v p as obtained from the colour M-mode Doppler images. In both animals and humans, Garcia and co-workers [59] found that left ventricular relaxation is a major determinant of v p , best described using a power function tau=592·21 v p 0·6838 (r= 0·78, P<0·001).…”

Echocardiographic evaluation of diastolic heart failure

“…Colour M‐Mode provides high temporal and spatial resolution in the assessment of the early diastolic filling velocity as blood propagates through the mitral valve 59 . Flow propagation velocity (Vp) is obtained by measuring the slope of the isovelocity line demarcated by the colour wavefront, representing the pressure gradient between the LV base and apex.…”