Left ventricular dysfunction in human immunodeficiency virus (HIV)-infected patients

Silva-Cardoso, José; Moura, Brenda; Martins, Leopoldo Henrique Barboza; Mota-Miranda, A.; Gonçalves, Francisco Rocha; Lecour, Henrique

doi:10.1016/s0167-5273(97)00276-3

Cited by 45 publications

(45 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study also reveal that the severity of immunodeficiency in HIV patients is associated with increased frequency and worsening of left ventricular dysfunction. Silva-Cardoso et al [33] reported similar finding in a study that recruited 98 HIV-positive patients in Portugal, where systolic dysfunction was noted to be worse with disease progression. Similar trend had been noted in other studies [9,11,15].…”

Section: Discussionsupporting

confidence: 54%

Echocardiographic abnormalities and disease severity (based on CD4 count) in treatment-naive HIV positive patients

Olusegun‐Joseph¹,

Ajuluchukwu²,

Mbakwem³

et al. 2017

HIV & AIDS Review

View full text Add to dashboard Cite

Purpose: Human immunodeficiency virus (HIV) infection may be associated with cardiac abnormalities. These abnormalities appear to be more frequent with disease progression. This study sought to examine the relationship between HIV disease severity in treatment-naive patients and cardiac abnormalities identified by echocardiography.Material and methods: 100 HIV-positive, treatment-naive patients, comprising 53 patients with CD4 count < 200/µl (AIDS group) and 47 patients with CD4 count ≥ 200/µl (non-AIDS group) without any traditional risk factors for cardiac disease were recruited for the study. Both groups had clinical and echocardiographic evaluation for cardiac abnormalities. Results:Of the 53 patients in the AIDS group, 11.5% had dilated cardiomyopathy (DCM), compared with none in the non-AIDS group (p = 0.018). Systolic dysfunction was higher in the AIDS group when compared with the non-AIDS group (42.3% and 17.0%, respectively; p = 0.006). Also, those in the AIDS had a significantly higher left ventricular end diastolic diameter index when compared with the non-AIDS group (2.87 ± 0.37 and 2.67 ± 0.29, respectively; p = 0.004). Furthermore, moderate to severe pericardial effusion was more frequent in the AIDS group, when compared with non-AIDS group (15.38% and 2.12%, respectively; p = 0.045). Diastolic dysfunction was also more frequent in AIDS group, although this did not achieve statistical significance (34.64% and 29.78%, respectively; p = 0.61). Conclusion:Cardiac abnormalities are more frequent with disease progression in HIV infected patients. Patients with more advanced disease (CD4 < 200/µl) had significantly more frequent systolic dysfunction, DCM, larger left ventricular dimension, and moderate to severe pericardial effusion than those with CD4 ≥ 200/µl.

show abstract

Section: Discussionsupporting

confidence: 54%

Echocardiographic abnormalities and disease severity (based on CD4 count) in treatment-naive HIV positive patients

Olusegun‐Joseph¹,

Ajuluchukwu²,

Mbakwem³

et al. 2017

HIV & AIDS Review

View full text Add to dashboard Cite

show abstract

“…[17][18][19][20][21][22][23][24] In fact, taken together these studies obtained dissimilar results: if preclinical diastolic dysfunction is often reported, LV mass has been found increased, normal or even reduced and LV systolic function normal or, in few studies, impaired. 38 Actually, these studies can hardly be compared with each other and with our study, mainly because of great differences in such relevant issues as methods employed (that is, clinic BP values, absolute values of LV mass instead of values indexed for body surface area or height ) and patients characteristics (asymptomatic HIV þ patients, HIV þ patients with various degrees of malnutrition, AIDS patients, mixed groups of asymptomatic and symptomatic HIV þ patients, only women, only African or African-American subjects).…”

Section: Left Ventricular Remodelling In Hiv Infection Am Grandi Et Almentioning

confidence: 99%

“…Moreover in some studies HIV þ patients and controls were significantly different with regard to smoking habit, BMI and/or BP values; often no information was available about BP profile or antihypertensive and antidyslipidemic treatment. [17][18][19][20][21][22][23][24] It is beyond the scope of this cross-sectional study to deal with the pathophysiologic mechanisms linking HIV infection and chronic HAART to LV remodelling. However, we can hypothesized that, besides other mechanisms like myocardial viral infection, direct myocardial mitochondrial toxicity by antiviral drugs and chronic inflammation, a relevant role could be played by metabolic complications.…”

Section: Left Ventricular Remodelling In Hiv Infection Am Grandi Et Almentioning

confidence: 99%

See 1 more Smart Citation

Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection

et al. 2011

View full text Add to dashboard Cite

The high cardiovascular risk of HIV infected (HIV þ ) patients is still partly unexplained. We aimed to evaluate if HIV infection and highly active antiretroviral therapy (HAART) are linked per se to left ventricular (LV) remodelling, independently of blood pressure (BP) values. We enrolled 4 groups of patients matched by gender, age, body mass index and smoking habit: 30 HIV þ hypertensives, 30 HIV þ normotensives, 30 notinfected (HIVÀ) hypertensives and 30 HIVÀ normotensives. HIV þ patients were on chronic HAART. Hypertension was newly diagnosed (p6 months) and never treated. Each patient underwent blood tests, 24-h BP monitoring and LV echocardiogram. The 4 groups had similar fasting glucose and cholesterol; triglycerides, HOMA index and prevalence of metabolic syndrome were higher in the HIV þ groups. Despite similar 24-h BP values, HIV þ hypertensives had greater LV mass and higher prevalence of preclinical diastolic dysfunction than HIVÀ hypertensives. Compared to HIVÀ normotensives, HIV þ normotensives had similar 24-h BP values, but greater LV mass and lower LV diastolic indices, similar to HIVÀ hypertensives, whose 24-h BP values were higher. Asymptomatic HIV infection and chronic HAART are associated with myocardial hypertrophy and preclinical diastolic dysfunction, independently of BP values.

show abstract

“…Similar findings have been reported by other workers. 13,28,29 Though echocardiography seems to be a useful technique for the early recognition and treatment of cardiac dysfunction in such patients; clinico-pathological studies may help to clarify the role of HIV virus and opportunistic infections in the pathogenesis of cardiac abnormalities found in HIV infected patients.…”

Section: Resultsmentioning

confidence: 99%

Study of cardiovascular manifestations in patients of HIV- its correlation with CD4 count and the ART regimen prescribed

et al. 2016

View full text Add to dashboard Cite

Left ventricular dysfunction in human immunodeficiency virus (HIV)-infected patients

Cited by 45 publications

References 32 publications

Echocardiographic abnormalities and disease severity (based on CD4 count) in treatment-naive HIV positive patients

Echocardiographic abnormalities and disease severity (based on CD4 count) in treatment-naive HIV positive patients

Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection

Study of cardiovascular manifestations in patients of HIV- its correlation with CD4 count and the ART regimen prescribed

Contact Info

Product

Resources

About