Left Ventricular Dilation and Incident Congestive Heart Failure in Asymptomatic Adults Without Cardiovascular Disease: Multi-Ethnic Study of Atherosclerosis (MESA)

Yeboah, Joseph; Bluemke, David A.; Hundley, W. Gregory; Rodríguez, Carlos J.; Lima, João A.C.; Herrington, David M.

doi:10.1016/j.cardfail.2014.09.002

Cited by 43 publications

(37 citation statements)

References 21 publications

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“…Several reports have demonstrated that ECG abnormalities in asymptomatic persons are predictive of incident HF [9–12]. Similarly, abnormalities of left ventricular structure and function on cardiac magnetic resonance imaging (MRI) are predictive of HF development [13, 14]. However, whether the presence of normal findings on routine ECG and cardiac MRI can identify individuals at a reduced risk for HF is currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA)

Broughton

O’Neal

Al‐Mallah

et al. 2017

International Journal of Cardiology

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Background It is unknown if normal findings on noninvasive cardiac assessment are able to identify individuals who are low risk for developing heart failure (HF). Methods We examined if normal findings on the routine electrocardiogram (ECG) and cardiac magnetic resonance imaging (MRI) were able to identify individuals who are low risk for developing HF in 4,986 (mean age=62 ± 10 years; 52% women; 39% White; 13% Chinese-American; 26% Black; 22% Hispanic) participants from the Multi-Ethnic Study of Atherosclerosis who were free of clinically apparent HF at baseline. A normal ECG was defined as the absence of major abnormalities by Minnesota Code Classification, and a normal MRI was defined as absence of structural abnormalities and systolic dysfunction. Results There were 3,988 (80%) participants with normal findings at baseline on both ECG and MRI, 894 (18%) who had either a normal ECG or normal MRI, and 104 (2%) who had abnormal findings on ECG and MRI. Over a median follow-up of 12.2 years, 177 (3.6%) HF events occurred. Normal ECG (HR=0.41, 95%CI=0.29, 0.56) and MRI (HR=0.32, 95%CI=0.23, 0.45) were each associated with lower risk of HF compared with abnormal, and their combination was associated with a lower HF risk (HR=0.13, 95%CI=0.08, 0.21) than either in isolation. Conclusion Normal findings on noninvasive cardiac assessment identify individuals in whom the risk of HF is low. Further studies are needed to explore the utility of this low-risk profile in HF prevention strategies.

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Section: Introductionmentioning

confidence: 99%

Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA)

Broughton

O’Neal

Al‐Mallah

et al. 2017

International Journal of Cardiology

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“…48 Similarly, in the Multi-Ethnic Study of Atherosclerosis left ventricular dilatation measured by cardiac magnetic resonance imaging was associated with increased incident heart failure independent of comorbidities and left ventricular ejection fraction. 49 These data suggest that an increase in the mean left ventricular size in biomass fuel users compared with non-users might increase the risk for heart failure even in the presence of normal left ventricular systolic function. However, longitudinal follow-up of our cohort is necessary to determine whether the observed increases in left atrial and left ventricular size predict adverse cardiovascular outcomes in this population.…”

Section: Discussionmentioning

confidence: 84%

Biomass fuel smoke exposure was associated with adverse cardiac remodeling and left ventricular dysfunction in Peru

et al. 2017

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While household air pollution from biomass fuel combustion has been linked to cardiovascular disease, the effects on cardiac structure and function have not been well described. We sought to determine the association between biomass fuel smoke exposure and cardiac structure and function by transthoracic echocardiography. We identified a random sample of urban and rural residents living in the high-altitude region of Puno, Peru. Daily biomass fuel use was self-reported. Participants underwent transthoracic echocardiography. Multivariable linear regression was used to examine the relationship of biomass fuel use with echocardiographic measures of cardiac structure and function, adjusting for age, sex, height, body mass index, diabetes, physical activity, and tobacco use. One hundred and eighty-seven participants (80 biomass fuel users and 107 non-users) were included in this analysis (mean age 59 years, 58% women). After adjustment, daily exposure to biomass fuel smoke was associated with increased left ventricular internal diastolic diameter (P=.004), left atrial diameter (P=.03), left atrial area (four-chamber) (P=.004) and (two-chamber) (P=.03), septal E′ (P=.006), and lateral E′ (P=.04). Exposure to biomass fuel smoke was also associated with worse global longitudinal strain in the two-chamber view (P=.01). Daily biomass fuel use was associated with increased left ventricular size and decreased left ventricular systolic function by global longitudinal strain.

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“…It was shown that increased LVED and LVES dimensions were associated with higher incidence of future HF. In another study, Yeboah et al demonstrated the association between LV dilatation measured by CMR at baseline with incident HF in 4974 MESA participants during over 9.4 years follow‐up …”

Section: Discussionmentioning

confidence: 98%

“…The clinical importance of subclinical LV dilatation has been shown in previous studies. [31][32][33] In a study on participants of the Framingham Heart Study and Framingham Offspring Study, 4744 individuals free of myocardial infarction and HF who underwent echocardiography at baseline were followed for incident HF. 32 It was shown that increased LVED and LVES dimensions were associated with higher incidence of future HF.…”

Section: Discussionmentioning

confidence: 99%

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Bakhshi

Ambale‐Venkatesh

Yang

et al. 2017

JAHA

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BackgroundAlthough the association between coronary artery calcium (CAC) and future heart failure (HF) has been shown previously, the value of CAC progression in the prediction of HF has not been investigated. In this study, we investigated the association of CAC progression with subclinical left ventricular (LV) dysfunction and incident HF in the Multi‐Ethnic Study of Atherosclerosis.Methods and ResultsThe Multi‐Ethnic Study of Atherosclerosis is a population‐based study consisting of 6814 men and women aged 45 to 84, free of overt cardiovascular disease at enrollment, who were recruited from 4 ethnicities. We included 5644 Multi‐Ethnic Study of Atherosclerosis participants who had baseline and follow‐up cardiac computed tomography and were free of HF and coronary heart disease before the second cardiac computed tomography. Mean (±SD) age was 61.7±10.2 years and 47.2% were male. The Cox proportional hazard models and multivariable linear regression models were deployed to determine the association of CAC progression with incident HF and subclinical LV dysfunction, respectively. Over a median follow‐up of 9.6 (interquartile range: 8.8–10.6) years, 182 participants developed incident HF. CAC progression of 10 units per year was associated with 3% of increased risk of HF independent of overt coronary heart disease (P=0.008). In 2818 participants with available cardiac magnetic resonance images, CAC progression was associated with increased LV end diastolic volume (β=0.16; P=0.03) and LV end systolic volume (β=0.12; P=0.006) after excluding participants with any coronary heart disease.Conclusions CAC progression was associated with incident HF and modestly increased LV end diastolic volume and LV end systolic volume at follow‐up exam independent of overt coronary heart disease.

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Left Ventricular Dilation and Incident Congestive Heart Failure in Asymptomatic Adults Without Cardiovascular Disease: Multi-Ethnic Study of Atherosclerosis (MESA)

Cited by 43 publications

References 21 publications

Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA)

Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA)

Biomass fuel smoke exposure was associated with adverse cardiac remodeling and left ventricular dysfunction in Peru

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

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