Left ventricular assist device may improve glycemic control in diabetes mellitus patients but the reverse is not true

Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices

“…Hospitalization for patients with HF tends to be very difficult since the circumstances are very demanding and challenging [57]. As a matter of fact, advanced HF, due to poor perfusion, causes neurohormonal imbalances (increase in cortisol and catecholamine levels [7]) and inadequate hemodynamics, which increase insulin resistance and deteriorate glycemic control [58].…”

“…The implantation of an LVAD can lead to an enhanced cardiac output and index, followed by reduced adrenergic stimulation, better tissue perfusion, and a boost in physical activity [58]. Post LVAD, there is a proven increase in blood flow reaching the pancreas, resulting in better glucose homeostasis and reduced insulin resistance in both diabetic and non-diabetic patients [7].…”