Left-right asymmetry of striatal dopamine D2 receptors

Larisch, Rolf; Meyer, W. M.; Klimke, A.; Kehren, F.; Vosberg, H.; Hw, Müller-Gärtner

doi:10.1097/00006231-199808000-00009

Cited by 78 publications

(46 citation statements)

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“…In humans, a recent review reported a population bias of higher D2 receptor binding in the right as compared to left striatum in healthy individuals (Larisch et al, 1998). This conclusion is based on group averages.…”

Section: Discussionmentioning

confidence: 99%

Incentive motivation is associated with striatal dopamine asymmetry

Tomer

Goldstein

Wang

et al. 2008

Biological Psychology

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Dopamine plays an important role in modulating incentive motivation, expressed behaviorally as approach behavior. EEG studies report association between approach behavior and asymmetric pattern of activation in anterior cortical regions (as measured by the inverse of EEG alpha power). Therefore, individual differences in incentive motivation may reflect asymmetries in dopaminergic systems. We examined this hypothesis by studying the relationship between self-reported degree of incentive motivation, and asymmetry of D2 receptor availability in healthy volunteers. Nineteen healthy participants were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors in left and right striatum.

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Section: Discussionmentioning

confidence: 99%

Incentive motivation is associated with striatal dopamine asymmetry

Tomer

Goldstein

Wang

et al. 2008

Biological Psychology

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“…Together, these findings suggest the presence of considerable asymmetry in the uptake of FDOPA is characteristic of caudate in normal subjects, and that haloperidol treatment preferentially reduced the FDOPA consumption on the abnormal left side of patients with schizophrenia (Table 1). In a meta-analysis of numerous [ 123 I]iodobenzamide/SPECT studies, higher D 2 binding in the right striatum of healthy subjects is consistently reported (Larisch et al, 1998). Altered asymmetry in preand postsynaptic markers of DA might underlie the leftturning bias reported in chronic schizophrenic patients (Bracha et al, 1993;Lyon and Satz, 1991).…”

Section: Discussionmentioning

confidence: 99%

Subchronic Haloperidol Downregulates Dopamine Synthesis Capacity in the Brain of Schizophrenic Patients In Vivo

Gründer¹,

Vernaleken²,

Müller³

et al. 2002

Neuropsychopharmacol

103

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The antipsychotic effect of neuroleptics cannot be attributed entirely to acute blockade of postsynaptic D 2 -like dopamine (DA) receptors, but may arise in conjunction with the delayed depolarization block of the presynaptic neurons and reduced DA synthesis capacity. Whereas the phenomenon of depolarization block is well established in animals, it is unknown if a similar phenomenon occurs in humans treated with neuroleptics. We hypothesized that haloperidol treatment should result in decreased DA synthesis capacity. We used 6-[ 18 F]fluoro-L-dopa (FDOPA) and positron emission tomography (PET) in conjunction with compartmental modeling to measure the relative activity of DOPA decarboxylase (DDC) (k D 3 , min À1 ) in the brain of nine unmedicated patients with schizophrenia, first in the untreated condition and again after treatment with haloperidol. Patients were administered psychometric rating scales at baseline and after treatment. Consistent with our hypothesis, there was a 25% decrease in the magnitude of k D 3 in both caudate and putamen following 5 weeks of haloperidol therapy. In addition, the magnitudes of k D 3 in cerebral cortex and thalamus were also decreased. Psychopathology as measured with standard rating scales improved significantly in all patients. The decrease of k D 3 in the thalamus was highly significantly correlated with the improvement of negative symptoms. Subchronic treatment with haloperidol decreased the activity of DDC in the brain of patients with schizophrenia. This observation is consistent with the hypothesis that the antipsychotic effect of chronic neuroleptic treatment is associated with a decrease in DA synthesis, reflecting a depolarization block of presynaptic DA neurons. We link an alteration in cerebral catecholamine metabolism in human brain with the therapeutic action of neuroleptic medication.

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“…Although these studies have indicated a relatively faster rate of decline than suggested by in vitro work, the actual decrease is probably smaller if a correction is applied for partial volume effects related to the decline in striatal size with age (Morris et al, 1999). Regarding the form of the rate of decline, several studies have suggested an exponential decline in D2 receptor density with age, (Wong et al, 1984;Antonini et al, 1993;Rinne et al, 1993;Ichise et al, 1998), whilst others have interpreted their findings as indicating a linear decline (Wong et al, 1988(Wong et al, , 1997Wang et al, 1998;Larisch et al, 1998). The differences between the conclusions may be attributable to the wide interindividual heterogeneity observed in the studies.…”

Section: Post-synaptic Mechanisms (I) D1/d2 Receptor Sitesmentioning

confidence: 97%

“…Wong et al, 1984) demonstrated a significant age-related decrease in D2 receptor density within both caudate and putamen of 6% and 4% per decade in men and women respectively (see Table 3). Despite sampling and methodological differences, subsequent studies have also consistently shown a significant decline in striatal D2 receptor density with age, ranging from 4 to 8% per decade using PET (Baron et al, 1986;Wong et al, 1988;Antonini et al, 1993;Rinne et al, 1993;Wang et al, 1995;Wong et al, 1997;Pohjahlainen et al, 1998;Volkow et al, 1998a, ) and 9 to13% per decade using SPECT (Woda et al, 1992;Ichise et al, 1998;Larisch et al, 1998), (see Table 3). Although these studies have indicated a relatively faster rate of decline than suggested by in vitro work, the actual decrease is probably smaller if a correction is applied for partial volume effects related to the decline in striatal size with age (Morris et al, 1999).…”

Section: Post-synaptic Mechanisms (I) D1/d2 Receptor Sitesmentioning

confidence: 99%