Incentive motivation is associated with striatal dopamine asymmetry

Tomer, Rachel; Goldstein, Rita Z.; Wang, Gene‐Jack; Wong, Christopher; Volkow, Nora D.

doi:10.1016/j.biopsycho.2007.08.001

Cited by 86 publications

(68 citation statements)

References 21 publications

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“…This right-greater-than-left asymmetry has been reported in previous studies where healthy people were found to have the right-greater-than-left asymmetry in D 2 receptor and DAT availability in the caudate (Laakso et al 2001;Tomer et al 2008). Moreover, several imaging studies in opioid or methamphetamine dependent subjects and healthy controls also found a slight right-great-than-left asymmetry in DAT levels in the striatum Liu et al 2013;Shi et al 2008;Yuan et al 2014).…”

Section: Discussionsupporting

confidence: 82%

Longitudinal changes of dopamine transporters in heroin users during abstinence

Liu

et al. 2015

Psychopharmacology

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Section: Discussionsupporting

confidence: 82%

Longitudinal changes of dopamine transporters in heroin users during abstinence

Liu

et al. 2015

Psychopharmacology

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“…Lateralization effects have been reported in human PET studies of the dopamine system (e.g., refs. 51 and 52) and also with respect to the association of these dopamine measurements with reward and motivation (53,54). However, results in the present study were derived from right-handed participants alone, and all reported correlations remained significant when controlling for dopamine measures from right and left striata.…”

Section: Limitationsmentioning

confidence: 47%

Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making

Deserno

Huys

Boehme

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

222

212

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Dual system theories suggest that behavioral control is parsed between a deliberative "model-based" and a more reflexive "modelfree" system. A balance of control exerted by these systems is thought to be related to dopamine neurotransmission. However, in the absence of direct measures of human dopamine, it remains unknown whether this reflects a quantitative relation with dopamine either in the striatum or other brain areas. Using a sequential decision task performed during functional magnetic resonance imaging, combined with striatal measures of dopamine using [ 18 F]DOPA positron emission tomography, we show that higher presynaptic ventral striatal dopamine levels were associated with a behavioral bias toward more model-based control. Higher presynaptic dopamine in ventral striatum was associated with greater coding of model-based signatures in lateral prefrontal cortex and diminished coding of model-free prediction errors in ventral striatum. Thus, interindividual variability in ventral striatal presynaptic dopamine reflects a balance in the behavioral expression and the neural signatures of model-free and model-based control. Our data provide a novel perspective on how alterations in presynaptic dopamine levels might be accompanied by a disruption of behavioral control as observed in aging or neuropsychiatric diseases such as schizophrenia and addiction.dopamine | decision making | reinforcement learning | PET | fMRI H uman choice behavior is influenced by both habitual and goal-directed systems (1). For example, having enjoyed a delicious dinner makes another subsequent visit to the same restaurant more likely. Upon returning at a later point, another visit could happen reflexively when walking past the restaurant, or alternatively be planned and involve reflection, for instance, by checking recent customer reviews to bolster against possible changes. These two decision modes differ fundamentally in terms of their control over actions and associated outcome consequences. Reflexive habitual preferences are retrospective and arise from a slow accumulation of rewards via iterative updating of expectations (2), for example by repeating dinner at the same place after having previously enjoyed tasty food there. In contrast, goal-directed behavior requires a prospective consideration of future outcomes associated with a set of actions (3). For example, knowledge that the chef has changed and subsequent reviews have been less good should reduce one's expectations. Thus, in the face of such change, a goaldirected system can adapt quickly, whereas a habitual system needs to experience an actual outcome before it can alter behavior in an adaptive manner (4). This dual-system theory has been formalized within computational models of learning that update expectations based on past rewards ("model-free") or map possible actions to their potential outcomes ("model-based") (5). There is evidence that model-based learning signals during the acquisition of task structure are encoded within prefrontal-parietal cortices, where...

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“…The rACC projects to the medial part of the ventral striatum (Kunishio & Haber, 1994), and recent findings suggest a role of the ACC and the ventral striatum in aE theta effects (see, e.g., O'Gorman et al, 2006, for effects within the caudate). Moreover, studies assessing dopamine receptor D2/3 availability have reported that the left ventral striatum correlates strongly with measures of extraversion (e.g., Tomer, Goldstein, Wang, Wong, & Volkow, 2008). Individual differences in ventral striatum activity may not only be related to resting delta/theta activity in the rACC, as previously shown (Wacker et al, 2009), but also contribute to the EEG posterior-anterior difference by modulating, for example, the insula and the posterior .42** Fig.…”

Section: Functional Significance Of Posterior Versus Anterior Theta: mentioning

confidence: 72%

Rostral anterior cingulate activity generates posterior versus anterior theta activity linked to agentic extraversion

Chavanon

Wacker

Stemmler

2010

Cogn Affect Behav Neurosci

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Recent research using the resting electroencephalogram (EEG) showed that posterior versus anterior theta activity (around 4-8 Hz) is consistently associated with agency, reflecting the dopaminergic core of extraversion (i.e., incentive motivation, positive emotion). Neuroimaging studies using various methodologies and experimental paradigms have converged on the anterior cingulate cortex (ACC) as a neurophysiological correlate of extraversion. The aim of the present study is integrate these lines of research by testing the hypothesis that posterior versus anterior EEG theta is at least partly based on ACC theta activity. Resting EEG data were analyzed in N = 78 healthy, male participants extremely high or low in agentic extraversion (aE). Using the low-resolution electromagnetic tomography algorithm, we localized the sources of aE-dependent intracerebral theta activity within rostral subdivisions of the ACC. The posterior versus anterior index and theta current density within the rostral ACC were significantly correlated (r = -.52), and both displayed high retest stability across 5 hr and were associated with traits from the aE spectrum. These neurophysiological correlates of aE and their possible functional significance are discussed.

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Incentive motivation is associated with striatal dopamine asymmetry

Cited by 86 publications

References 21 publications

Longitudinal changes of dopamine transporters in heroin users during abstinence

Longitudinal changes of dopamine transporters in heroin users during abstinence

Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making

Rostral anterior cingulate activity generates posterior versus anterior theta activity linked to agentic extraversion

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