Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia

Veelen, N.M.J. van; Vink, Matthijs; Ramsey, Nick F.; Kahn, René S.

doi:10.1016/j.schres.2010.07.004

Cited by 62 publications

(38 citation statements)

References 62 publications

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“…The following regions of interest were identified from an independent sample that performed the same task: left fusiform gyrus, left dorsolateral prefrontal cortex, left and right superior parietal cortex, and anterior cingulate. A previous study from these investigators demonstrated that activation within the left dorsolateral prefrontal cortex did not attenuate with practice in antipsychotic naïve SP [3]. After 70 days of treatment with antipsychotic medications, SP continued to have more activation during the practice trails and did not change activation patterns in the dorsolateral prefrontal cortex.…”

Section: Blasi Et Al (2009) Assessed Changes In Amygdala and Prefronmentioning

confidence: 80%

“…Cross-sectional studies comparing medicated patients with schizophrenia (SP) and healthy comparison subjects (HC) often attribute group differences to neuronal dysfunction or disconnection related to the disease process despite the obvious confound of antipsychotic treatment. Schizophrenia investigations with first-degree relatives, unmedicated prodromal, or antipsychotic naïve, first-episode patients are immune to the effect of antipsychotics via the lack of exposure and are valuable at elucidating the pathophysiology of the disease process [1][2][3]. The costs of these investigations include the recruitment challenges, ethical considerations, and limited generalizability to clinical populations who are often medicated.…”

Section: Introductionmentioning

confidence: 99%

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Antipsychotic Drug Effects in Schizophrenia: A Review of Longitudinal fMRI Investigations and Neural Interpretations

Abbott¹,

Jaramillo²,

Wilcox³

et al. 2013

Current Medicinal Chemistry

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The evidence that antipsychotics improve brain function and reduce symptoms in schizophrenia is unmistakable, but how antipsychotics change brain function is poorly understood, especially within neuronal systems. In this review, we investigated the hypothesized normalization of the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal in the context of antipsychotic treatment. First, we conducted a systematic PubMed search to identify eight fMRI investigations that met the following inclusion criteria: case-control, longitudinal design; pre-and post-treatment contrasts with a healthy comparison group; and antipsychotic-free or antipsychoticnaïve patients with schizophrenia at the start of the investigation. We hypothesized that aberrant activation patterns or connectivity between patients with schizophrenia and healthy comparisons at the first imaging assessment would no longer be apparent or "normalize" at the second imaging assessment. The included studies differed by analysis method and fMRI task but demonstrated normalization of fMRI activation or connectivity during the treatment interval. Second, we reviewed putative mechanisms from animal studies that support normalization of the BOLD signal in schizophrenia. We provided several neuronal-based interpretations of these changes of the BOLD signal that may be attributable to long-term antipsychotic administration.

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Section: Blasi Et Al (2009) Assessed Changes In Amygdala and Prefronmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Antipsychotic Drug Effects in Schizophrenia: A Review of Longitudinal fMRI Investigations and Neural Interpretations

Abbott¹,

Jaramillo²,

Wilcox³

et al. 2013

Current Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…Indeed, neuroimaging studies have consistently shown frontostriatal impairments in schizophrenia patients. First, functional MRI studies have demonstrated reduced levels of frontostriatal activation in patients in the context of several cognitive tasks including working memory, reward processing, and inhibition (Morris et al, 2012;van Veelen et al, 2010van Veelen et al, , 2011Vink et al, 2006;Zandbelt et al, 2011). Second, patients show decreased frontal and striatal volumes (Emsley et al, 2015;Harms et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Changes in White Matter Organization in Adolescent Offspring of Schizophrenia Patients

Leeuw

Bohlken

Mandl

et al. 2016

Neuropsychopharmacol

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Schizophrenia is associated with frontostriatal network impairments underlying clinical and cognitive symptoms. We previously found disruptions in anatomical pathways, including the tract connecting the left nucleus accumbens and left dorsolateral prefrontal cortex (DLPFC). Similar deficits are observed in unaffected siblings of schizophrenia patients, indicating that these deficits are linked to a genetic vulnerability for the disorder. Frontostriatal tract disruptions may arise during adolescence, preceding the clinical manifestation of the disorder. However, to date, no studies have been performed to investigate frontostriatal tract connections in adolescents who are at increased familial risk for schizophrenia. In this study, we investigate the impact of familial risk on frontostriatal tract connections using diffusion tensor imaging in 27 adolescent offspring of schizophrenia patients and 32 matched control adolescents, aged 10-18 years. Mean fractional anisotropy (FA) was calculated for the tracts connecting the striatum (caudate nucleus, putamen, nucleus accumbens) and frontal cortex regions (DLPFC, medial orbital frontal cortex, inferior frontal gyrus). As expected, based on siblings data, we found an impact of familial risk on frontostriatal development: schizophrenia offspring showed increased FA in the tracts connecting nucleus accumbens and DLPFC as compared with control adolescents. Moreover, while FA increased across age in control adolescents, it did not in schizophrenia offspring. We did not find differences in FA in other frontostriatal tracts. These results indicate altered development of white matter in subjects who are at familial risk for schizophrenia and may precede frontostriatal white matter alterations in adult schizophrenia patients and siblings.

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“…However, a review of cognitive remediation programmes revealed only a small to moderate effect on global cognition and functioning in patients with schizophrenia (Wykes, Huddy, Cellard, McGurk, & Czobor, 2011). Empirical findings using functional imaging showed inconsistent findings of activation decrease (Koch et al, 2007;van Veelen, Vink, Ramsey, & Kahn, 2010) and increase after WM intervention (Haut, Lim, & MacDonald, 2010;Wexler, Anderson, Fulbright, & Gore, 2000). Since many of these studies are characterized by different training regimens, small sample size and heterogeneity of baseline characteristics of patients, an integration of these studies using meta-analysis is indicated.…”

Section: Introductionmentioning

confidence: 99%

The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

Xiao

Zhao

et al. 2015

Neuropsychologia

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Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia

Cited by 62 publications

References 62 publications

Antipsychotic Drug Effects in Schizophrenia: A Review of Longitudinal fMRI Investigations and Neural Interpretations

Antipsychotic Drug Effects in Schizophrenia: A Review of Longitudinal fMRI Investigations and Neural Interpretations

Changes in White Matter Organization in Adolescent Offspring of Schizophrenia Patients

The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

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