The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

Li, Xu; Xiao, Ya-hui; Zhao, Qing; Leung, Ada; Cheung, Eric F.C.; Chan, Raymond C. K.

doi:10.1016/j.neuropsychologia.2015.05.029

Cited by 50 publications

(38 citation statements)

References 85 publications

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“…This coincides with improved cognitive functioning in people with ADHD; (Klingberg, 2010, Spencer-Smith and Klingberg, 2015), schizophrenia (Li et al, 2015) and some evidence in those with substance use disorder (Brooks et al, n.d, Bickel et al, 2015, Wesley and Bickel, 2014). For example, computerized WM training has been shown to reduce impulsivity and delay discounting (lowering the preference for immediate over delayed rewards) among stimulant users (Bickel et al, 2011).…”

Section: Discussionsupporting

confidence: 54%

“…A recent meta-analysis of WM training in both HC and patients with schizophrenia demonstrates that greater activation incorporating frontoparietal networks, the DLPFC and anterior cingulate, as well as the striatum, are associated with neuroplasticity changes (Li et al, 2015). Additionally, previous studies have shown that cerebellar (Ding et al, 2012), striatum, lateral prefrontal and frontoparietal grey matter volume alterations are associated with WM capacity (Ruge and Wolfensteller, 2015), and that larger volume in the lateral prefrontal cortex is particularly susceptible to variations in WM capacity (Reid et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…To aid the formulation of our hypotheses we referred to a recent meta-analysis of WM training in both HC and patients with schizophrenia that demonstrated that greater activation incorporating fronto-parietal networks, the DLPFC and anterior cingulate (ACC), as well as the striatum, are associated with neuroplasticity changes (Li et al, 2015). Furthermore, CT is consistently reported to improve cognitive function in those with psychosis (Keshavan et al, 2014) and attention deficit hyperactivity disorder (ADHD) (Klingberg, 2010, Shinaver et al, 2014, Spencer-Smith and Klingberg, 2015), which are highly comorbid with regular MA use (Harro, 2015, Hides et al, 2015) and so CT is relevant for our study population.…”

Section: Introductionmentioning

confidence: 99%

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Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Brooks

Burch

Maiorana

et al. 2016

NeuroImage: Clinical

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BackgroundProtracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known.Methods66 males (41 MA patients, 25 healthy controls, HC) between the ages of 18–50 were recruited, the MA patients from new admissions to an in-patient drug rehabilitation centre and the HC via public advertisement, both in Cape Town, South Africa. 17 MA patients received 4 weeks of treatment as usual (TAU), and 24 MA patients completed TAU plus daily 30-minute cognitive training (CT) using an N-back working memory task. Magnetic resonance imaging (MRI) at baseline and 4-week follow-up was acquired and voxel-based morphometry (VBM) was used for analysis.ResultsTAU was associated with larger bilateral striatum (caudate/putamen) volume, whereas CT was associated with more widespread increases of the bilateral basal ganglia (incorporating the amygdala and hippocampus) and reduced bilateral cerebellum volume coinciding with improvements in impulsivity scores.ConclusionsWhile psychological intervention is associated with larger volume in mesolimbic reward regions, the utilisation of additional working memory training as an adjunct to treatment may further normalize frontostriatal structure and function.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Brooks

Burch

Maiorana

et al. 2016

NeuroImage: Clinical

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“…There is a large body of evidence from functional magnetic resonance imaging studies suggesting that cognitive deficits in patients with schizophrenia are associated with decreased activity of the frontal region, especially the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, and the medial frontal cortex 34,35. In contrast, neuroimaging studies have shown that cortical cerebellar and global cerebellar volumes are significantly reduced in patients with schizophrenia compared to healthy controls 36.…”

Section: Discussionmentioning

confidence: 99%

The <em>NCAN</em> gene: schizophrenia susceptibility and cognitive dysfunction

Wang

Cai

et al. 2016

NDT

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BackgroundCognitive dysfunction has been recognized as a cardinal feature of schizophrenia. Elucidating the neurobiological substrates of cognitive dysfunction in schizophrenia would help identify the underlying mechanism of this disorder. The rs1064395 single nucleotide polymorphism, within the gene encoding neurocan (NCAN), is reported to be associated with schizophrenia in European populations and may influence brain structure in patients with schizophrenia.MethodsIn this study, we aimed to explore whether NCAN rs1064395 confers some risk for schizophrenia and cognitive dysfunction in Han Chinese. We recruited 681 patients with schizophrenia and 699 healthy subjects. Two hundred and fifty-four patients were evaluated according to Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).ResultsThere were no significant differences in genotype or allele distributions of the rs1064395 polymorphism between the schizophrenia and control groups. Patients showed significantly poorer performance than controls on immediate memory, visuospatial skill, language, attention, delayed memory, and total RBANS score. Patients with the A/A or A/G genotype of rs1064395 had lower scores of immediate memory, visuospatial skill, attention, and total RBANS score than those with the G/G genotype. We performed an expression quantitative trait loci analysis and observed a significant association between rs1064395 and NCAN expression in the frontal (P=0.0022, P=0.022 after Bonferroni correction) and cerebellar cortex (P=0.0032, P=0.032 after Bonferroni correction).ConclusionOur findings indicate that this single nucleotide polymorphism may be a risk factor for cognitive dysfunction in patients with schizophrenia. Further investigations are warranted for validation purposes and to identify the precise mechanism by which rs1064395 influences cognitive performance in patients with schizophrenia.

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“…During these sessions, patients are required to quietly attend to the task without disruption and touch the screen of their phone when they see the target letter in a series of letters (see “Materials and methods” for more detailed explanation). In this vein, WM training has been effectively utilised to improve prognosis for other psychiatric populations, particularly in disorders that are comorbid with SUD (Akindipe et al 2014), such as learning difficulties (Peijnenborgh et al 2016), mood disorders (Meusel et al 2013), psychosis (Li et al 2015) and anxiety (Sari et al 2016). In terms of efficacy of WM training for SUD, it has shown to be an effective strategy to reduce alcohol use by increasing control over automatic impulses to drink alcohol (Houben et al 2011) and to reduce engagement in stimulant use (Bickel et al 2011).…”

Section: Introductionmentioning

confidence: 99%

The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users

et al. 2017

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ObjectivesImpulsivity is a vulnerability trait for poor self-regulation in substance use disorder (SUD). Working memory (WM) training improves impulsivity and self-regulation in psychiatric disorders. Here we test WM training in methamphetamine use disorder (MUD).MethodsThere are 15 MUD patients receiving inpatient treatment as usual (TAU) and 20 who additionally completed WM cognitive training (CT) and 25 healthy controls (HC). MANCOVA repeated measures analyses examined changes in impulsivity and self-regulation at baseline and after 4 weeks.ResultsPost hoc t tests confirmed that at baseline, feelings of self-control were significantly lower in the MUD (t = 2.001, p = 0.05) and depression was higher (t = 4.980, p = 0.001), as was BIS total impulsivity (t = 5.370, p = 0.001) compared to the HC group. Total self-regulation score was higher in HC than MUD patients (t = 5.370, p = 0.001). CT had a 35% learning rate (R 2 = 0.3523, p < 0.05). Compared to follow-up TAU, follow-up CT group had higher self-reported mood scores (t = 2.784, p = 0.01) and higher compared to CT baseline (t = 2.386, p = 0.036). Feelings of self-control were higher in CT than TAU at follow-up (t = 2.736, p = 0.012) and also compared to CT baseline (t = 3.390, p = 0.006), lack of planning significantly improved in CT between baseline and follow-up (t = 2.219, p = 0.048), as did total impulsivity scores (t = 2.085, p = 0.048). Measures of self-regulation were improved in the CT group compared to TAU at follow-up, in total score (t = 2.442, p = 0.038), receiving score (t = 2.314, p = 0.029) and searching score (t = 2.362, p = 0.027). Implementing self-regulation was higher in the CT group compared to TAU (t = 2.373, p = 0.026).ConclusionsWM training may improve control of impulsivity and self-regulation in people with MUD.

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The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation

Cited by 50 publications

References 85 publications

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

Psychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use

The <em>NCAN</em> gene: schizophrenia susceptibility and cognitive dysfunction

The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users

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