Left dominance of EEG abnormalities in patients with transient global amnesia

Kwon, Yoo Seok; Yang, Young Soon; Jang, Jae Won; Park, Young Ho; Kim, Jung Eun; Park, Seong-Ho; Kim, SangYun

doi:10.1016/j.seizure.2014.06.014

Cited by 15 publications

(29 citation statements)

References 30 publications

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“…In addition, the voxel-based whole brain analysis also revealed cerebral hypoperfusion in the left inferior temporal and superior parietal cortex and in the left precuneus. This finding of left lateralization is in line with other studies that reported some left dominance of functional abnormalities confirmed via EEG, perfusion MRI or SPECT abnormalities [ 27 , 28 , 54 , 55 ]. Considering that visual reading of SPECT images and DWI lesions are not related to left dominance ( Table 1 ), there may be some discrepancies from the findings of the voxel-based whole brain analysis or the quantitative ECD uptake.…”

Section: Discussionsupporting

confidence: 92%

“…One possible explanation is that the effect of left cerebral hypoperfusion contributing to amnestic events in TGA patients could be greater or persist longer than that of the right side, although bilateral cerebral hypoperfusion may occur at the initial stage of TGA. We speculated that this finding regarding left laterality could be closely linked to a previous study reported by our team, which revealed significant left predominance of EEG abnormalities [ 54 ].…”

Section: Discussionsupporting

confidence: 79%

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Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption

Jang

Park

et al. 2015

PLoS ONE

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BackgroundThe pathophysiology of transient global amnesia (TGA) is not fully understood. Previous studies using single photon emission computed tomography (SPECT) have reported inconclusive results regarding cerebral perfusion. This study was conducted to identify the patterns of regional cerebral blood flow (rCBF) in TGA patients via longitudinal SPECT analysis. An association between the observed SPECT patterns and a pathophysiological mechanism was considered.MethodsBased on the TGA registry database of Seoul National University Bundang Hospital, 22 TGA patients were retrospectively identified. The subjects underwent initial Tc-99m-ethyl cysteinate dimer (ECD) SPECT within 4 days of an amnestic event and underwent follow-up scans approximately 6 months later. The difference in ECD uptake between the two scans was measured via voxel-based whole brain analysis, and the quantified ECD uptake was tested using a paired t-test.ResultsThe TGA patients had significantly decreased cerebral perfusion at the left precuneus (P<0.001, uncorrected) and at the left superior parietal and inferior temporal gyrus according to the voxel-based whole brain analysis (P<0.005, uncorrected). A difference in the quantified ECD uptake between the 2 scans was also found at the left precuneus among the 62 cortical volumes of interest (P = 0.018, Cohen’s d = -0.25).ConclusionWe identified left hemispheric lateralized hypoperfusion that may be related to posterior medial network disruption. These findings may be a contributing factor to the pathophysiology of TGA.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 79%

Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption

Jang

Park

et al. 2015

PLoS ONE

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Section: Discussionsupporting

confidence: 93%

“…These findings are compatible with our previous study using VBM, which also found volume reductions in the left hippocampus only. This left lateralization is consistent with other previous studies using EEG and SPECT (Chung et al, 2009;Jang et al, 2015;Kwon et al, 2014). Kim et al analyzed EEG abnormalities in patients with TGA; epileptiform discharge, or focal slowing, was detected in the left hemisphere only (54.3%) or in both hemispheres (28.6%), but not in the right hemisphere only (0%) .…”

Section: Discussionsupporting

confidence: 87%

“…Kim et al. analyzed EEG abnormalities in patients with TGA; epileptiform discharge, or focal slowing, was detected in the left hemisphere only (54.3%) or in both hemispheres (28.6%), but not in the right hemisphere only (0%) (Kwon et al., ). The same research group also found, via SPECT analysis, that patients with TGA had significantly decreased cerebral perfusion in the left hemisphere only (Jang et al., ).…”

Section: Discussionmentioning

confidence: 99%

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Cortical morphology in patients with transient global amnesia

et al. 2017

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ObjectiveThis study evaluated alterations in cortical morphology in patients with transient global amnesia (TGA).Materials and MethodsDiagnoses of TGA occurred at our hospital. Evaluation involved a structured interview to obtain clinical information and a brain magnetic resonance imaging scan. We analyzed whole‐brain T1‐weighted MRI data using FreeSurfer 5.1. Measures of cortical morphology, such as thickness, surface area, volume, and curvature were compared between patients with TGA and healthy controls. We also quantified the correlations between clinical variables and each measure of abnormal cortical morphology.ResultsSeventy patients met the inclusion criteria. Compared to healthy controls, patients with TGA had significant alterations in cortical thickness in several regions of bilateral hemisphere. Moreover, several regions of cortical volumes in left hemisphere were significantly different between patients with TGA and healthy controls. In addition, there were significant correlations between the durations of episodes and cortical thickness, especially in the parietal cortex. However, there were no differences between groups in other measures of cortical morphology, including surface area and curvatures.ConclusionsWe observed significant alterations in cortical morphology in patients with TGA; these alterations are implicated in the pathogenesis of TGA.

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Kopfschmerz bei Parietal- und Okzipitallappenepilepsien

Birk¹,

Noachtar²,

Kaufmann³

2020

Z. Epileptol.

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ZusammenfassungEpilepsiepatienten leiden überdurchschnittlich häufig unter Kopfschmerzen. Dies gilt insbesondere für Patienten mit idiopathisch generalisierten und parietookzipitalen Epilepsien. Die Häufigkeit des gemeinsamen Auftretens von Kopfschmerzen und Epilepsie überschreitet dabei die rechnerische Koinzidenz, sodass von einer Komorbidität beider Syndrome auszugehen ist. Bestärkt wird diese Hypothese durch überlappende genetische Veränderungen sowie gemeinsame pathophysiologische Mechanismen. Bis zu 62 % der Patienten mit z. B. Parietal- und Okzipitallappenepilepsie (POLE) geben Kopfschmerzen an. Diese treten v. a. nach dem Anfall (postiktal) auf und manifestieren sich am häufigsten als Migräne-ähnlicher Kopfschmerz oder Spannungskopfschmerz. Seltener kommt es zu Kopfschmerzen vor (periiktal), während (iktal) oder zwischen (interiktal) epileptischen Anfällen. Bei transienten neurologischen Ausfallsymptomen mit begleitenden Kopfschmerzen ist differenzialdiagnostisch neben der Migräne an vaskuläre Ereignisse wie Synkopen oder eine transiente ischämische Attacke zu denken.

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Left dominance of EEG abnormalities in patients with transient global amnesia

Cited by 15 publications

References 30 publications

Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption

Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption

Cortical morphology in patients with transient global amnesia

Kopfschmerz bei Parietal- und Okzipitallappenepilepsien

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