Cortical morphology in patients with transient global amnesia

Kim, Hyung Chan; Lee, Ki Young; Kim, Sung Eun; Park, Kang Min

doi:10.1002/brb3.872

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…Only studies using diffusion-weighted magnetic resonance imaging (MRI) have consistently shown that the acute stage of TGA is associated with precise focal lesions in the hippocampus [4,5]. In addition, we recently used quantitative analysis of MRI to demonstrate that patients with TGA have significant gray matter volume reductions in several regions, such as hippocampus, cingulum, and cerebellum [6]. Patients with TGA also have significant alterations in cortical thickness in several regions of frontal, temporal, parietal, and occipital lobes of bilateral hemisphere [7].…”

Section: Introductionmentioning

confidence: 99%

Is Transient Global Amnesia a Network Disease?

2018

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Background: We evaluated a brain network using graph theoretical analysis and microstructural abnormalities of the white matter in patients with transient global amnesia (TGA). Methods: Twenty patients with TGA and healthy control subjects were recruited, and they underwent diffusion tensor imaging (DTI) scans. Graph theory was applied to obtain network measures based on DTI data. We investigated the network measures and microstructural abnormalities of white matter using tract-based spatial statistics (TBSS) analysis in the patients with TGA. Results: Measures of global topology were not different between the patients with TGA and healthy subjects. However, there were significant differences of hubs organization; the strength of the right superior and inferior orbitofrontal, the right inferior frontal operculum, the left superior parietal, and left postcentral gyrus, the cluster coefficient of the right middle orbitofrontal and left inferior parietal gyrus, the betweenness centrality of the left angular gyrus, and the pagerank centrality of the right superior and inferior orbitofrontal, right inferior frontal operculum, left superior parietal, and left postcentral gyrus in the patients with TGA were significantly lower than those in healthy subjects. Regarding the analysis of the white matter microstructure with TBSS, there were no differences in the fractional anisotropy and mean diffusivity values between the 2 groups. Conclusions: We newly identify a reorganization of network hubs of the brain network in patients with TGA, especially in the regions of the default-mode network. These alterations of the brain network may play a role in the pathophysiologic mechanism underlying TGA and suggest that TGA is a network disease.

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Section: Introductionmentioning

confidence: 99%

Is Transient Global Amnesia a Network Disease?

2018

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“…With regard to the VBM results, greater hippocampal GMV in TGA+ vs TGA- was unexpected and appears at odds with past research demonstrating that patients with TGA have significant GMV reduction in the hippocampus ( Park et al, 2015 ) and widespread alterations in cortical morphology (including cortical thickness and volume) compared to healthy controls ( Kim et al, 2017 ). In our study, differences in GMV were mainly located within the CA1 subfield of the hippocampus.…”

Section: Discussionmentioning

confidence: 56%

Hippocampal gray matter volume in the long-term course after transient global amnesia

Pirlich

Höfer

Weise

et al. 2021

NeuroImage: Clinical

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“…26 To compare the cortical thickness between patients and controls we performed an ROI analysis, which is potentially more sensitive than the voxel-based approach previously used in patients with TGA. 8 Decreased cortical thickness involved the orbitofrontal, cingulate, and inferior temporal cortices of patients with TGA. Interestingly, several regions of the limbic network showed alterations of both structural connectivity and cortical thickness (left subcallosal gyrus, left lateral orbital sulcus, left middle anterior cingulate cortex, and right opercular inferior frontal gyrus), further strengthening our results.…”

Section: Characteristics Of Patientsmentioning

confidence: 99%

“…Using cortical morphometry, pre-existing structural abnormalities were reported in patients with TGA mainly involving the default mode network. 7,8 The thalamus and the prefrontal cortex have been reported to be functionally altered during TGA by using positron emission tomography assessment. [9][10][11] Using single-photon emission CT, Jang et al 12 found that anterior lesions on DWI were associated with hypoperfusion of the frontal and anterior temporal areas whereas posterior lesions were associated with hypoperfusion of the parietal, posterior temporal, occipital, and cerebellar areas.…”

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confidence: 99%

Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia

Hodel¹,

Leclerc

Zuber

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Transient global amnesia (TGA) is a sudden onset of anterograde and retrograde amnesia. We aimed to assess differences in terms of cortical thickness and structural brain connectome between patients with TGA (at acute and delayed postrecovery stages) and matched controls. MATERIALS AND METHODS:We report on 18 consecutive patients with TGA who underwent 3T MR imaging, including DTI and MPRAGE sequences, at the acute (mean delay postonset: 44 hours) and delayed post-recovery (mean delay: 35 days) stages. Structural connectome was assessed in patients with TGA and in 18 age-and sex-matched controls by using probabilistic fibertracking and segmentation of 164 cortical/subcortical structures ("nodes"). Connectivity graphs were computed and global network metrics were calculated. Network-based statistical analysis (NBS) was applied to compare patients with TGA at each stage with controls. We also compared cortical thickness between patients with TGA and healthy controls.RESULTS: Global network metrics were not altered in patients with TGA. NBS-analysis showed structural connectome alterations in patients with TGA compared with controls, in core regions involving the limbic network, with 113 nodes and 114 connections (33 left intrahemispheric, 31 right intrahemispheric, and 50 interhemispheric connections) showing significantly decreased structural connectivity (P , .05 NBS corrected, t-values ranging from 3.03 to 8.73). Lower cortical thickness compared with controls was associated with these structural alterations in patients with TGA, involving the orbitofrontal, cingulate, and inferior temporal cortices. All the abnormalities were visible at both acute and delayed postrecovery stages.CONCLUSIONS: Our preliminary study suggests there are structural abnormalities of the limbic network in patients with TGA compared with controls, including decreased structural connectivity and cortical thickness. ABBREVIATIONS: TGA ¼ transient global amnesia; TOF-MRA ¼ time-of-flight MRA; VBM ¼ voxel-based morphometry; AUC ¼ area under the curve; FDR ¼ false discovery rate; NBS ¼ network-based statistical analysis

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Cortical morphology in patients with transient global amnesia

Cited by 11 publications

References 39 publications

Is Transient Global Amnesia a Network Disease?

Is Transient Global Amnesia a Network Disease?

Hippocampal gray matter volume in the long-term course after transient global amnesia

Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia

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