Left Axilla Adenocarcinoma of Unknown Origin

Jiang, Heng; Lele, Subodh M.; Santamaria-Barria, Juan A.

doi:10.1001/jamaoncol.2022.7858

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2023

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“…Circulating uterine tumor cells must enter the parenchyma via the arterial inflow in the LN hilum. Any of the more common malignancies, with tumor cells circulating in the bloodstream [ 20 ], can theoretically metastasize to non-regional LNs such as in the axilla [ 21 ], but the literature has very few examples of this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report

Morrison,

Sanjasaz,

Nathanson

et al. 2023

J Med Case Reports

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Background We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. Case presentation In this report, a 68-year-old white woman with a dedifferentiated endometrial carcinoma underwent a hysterectomy. She later developed an enlarged axillary lymph node due to metastatic dedifferentiated endometrial carcinoma, treated with chemotherapy and anti-programmed cell death protein 1 immunotherapy resulting in a complete clinical and radiological response. Conclusion A review of the literature reveals the rarity of blood-borne lymph node metastasis, especially with uterine carcinoma. Immunotherapy has shown promising results in the treatment of some subtypes of metastatic uterine carcinoma.

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Section: Discussionmentioning

confidence: 99%