Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report

Abstract

Background We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. Case presentation In this report, a 68-year-old white woman with a dedifferentiated endometrial carcinoma underwent a hysterectomy. She later developed an enlarged axillary lymph node due to metastatic dedifferentiated endometrial carcinoma, treated with chemotherapy and anti-programmed cell death protein 1 immunotherapy resulting in a complete clinical and radiological response. Conclusion A review of the literature reveals the rarity of blood-borne lymph node metastasis, especially with uterine carcinoma. Immunotherapy has shown promising results in the treatment of some subtypes of metastatic uterine carcinoma.

Beyond the Boundaries: a Case Report of Dedifferentiated Endometrial Carcinoma Masquerading as a Neurological Disorder

“…Although DEC has a reputation for acting aggressively, there are few records of it spreading so widely. 9 This case is exceptional due to the combination of a rare presentation (a seizure-like event), widespread multi-organ metastases that includes brain and a rapid-progressing disease. The disorder is di cult to detect since endometrial cancer does not usually presents neurologically and lacks conventional symptoms associated with the disease.…”

Isolated left axillary nodal metastasis from endometrial carcinosarcoma: A case report and literature review

“…Few reports of axillary LN metastases from endometrial cancers do exist but the pathological and clinical variables responsible for this unusual pattern of spread are unknown ( [12] , [13] , [14] ). To the best of our knowledge, our case could be the first reported case of isolated metastatic axillary LN from uterine carcinosarcoma presenting as the initial symptom without pelvic or abdominal LN involvement.…”

“…Another reported case of dedifferentiated endometrial carcinoma showed metastasis to the axillary lymph node as a recurrent site 4 months following treatment ( 13 ).…”