Left Atrial Appendages Occlusion: Current Status and Prospective

Sharma, Sharan Prakash; Park, Peter J.; Lakkireddy, Dhanunjaya

doi:10.4070/kcj.2018.0231

Cited by 22 publications

(20 citation statements)

References 57 publications

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“…It went a step further to propose that patients on OAC had better outcomes [11]. However, a study was conducted by Sharma et al that studied different LAAO devices, and their findings showed that LAAO devices were adequate for the prevention of stroke [12]. This study is a review; hence, it has precedence over the previously mentioned case-control study based on the premise that the study has a higher quality of evidence.…”

Section: Figure 1: Safety Concerns With Laao and Oacmentioning

confidence: 98%

Comparison Between Oral Anticoagulation and Left Atrial Appendage Occlusion in the Prevention of Stroke With Regard to Non-Valvular Atrial Fibrillation

Sandhu¹,

Aftab²,

Anthony³

et al. 2020

Cureus

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In the past, the most common type of atrial fibrillation leading to stroke was valvular; this was predominantly due to the prevalence of rheumatic fever, but with the advent of better-hospitalized care, the cases of valvular atrial fibrillation declined. In recent years, there has been an increase in cases of stroke due to non-valvular atrial fibrillation. Stasis of blood in the left atrial pouch leads to coagulation and thrombi formation, which may lead to stroke. Oral medication or mechanical intervention can prevent thrombi formation. Both oral anticoagulation and left atrial appendage occlusion (LAAO) have been compared to see which has better outcomes. It was observed that LAAO has greater efficacy, but with time throughout a couple of years, no considerable difference was seen when compared to warfarin. Most of the long-term randomized controlled trials have been performed with the Watchman ® device. Although the Lariat and Amplatzer LAAO devices have also shown favorable outcomes, there is still a deficiency when it comes to trials of high-quality evidence using these devices as an intervention. Dual therapy with both of these approaches showed a decline in the count of major bleeding episodes on follow-up. Overall, albeit both methods have proven useful, LAAO has a slight advantage in efficacy and leads to less hemorrhagic events.

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Section: Figure 1: Safety Concerns With Laao and Oacmentioning

confidence: 98%

Comparison Between Oral Anticoagulation and Left Atrial Appendage Occlusion in the Prevention of Stroke With Regard to Non-Valvular Atrial Fibrillation

Sandhu¹,

Aftab²,

Anthony³

et al. 2020

Cureus

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“…Left atrial appendage (LAA) occlusion/ligation using one of several devices or surgical techniques has been developed as an alternative to anticoagulation in high‐risk patients with non‐valvular AF 280–282 . The maximum experience has been with the Watchman device (Boston Scientific), which has been found to be non‐inferior to warfarin in patients who are still candidates for short‐term warfarin treatment 283–285 .…”

Section: How To Assess Risk For Adverse Outcomes In Patients With Atrmentioning

confidence: 99%

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

Nielsen

Lin

Figueiredo

et al. 2020

Journal of Arrhythmia

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“…However, there are no one-size-fits-all NOACs, and this also applies to elderly, particularly the vulnerable patients [43]. Furthermore, a significant proportion of geriatric patients cannot be treated with the necessary OAC because of the comorbidities, and in these patients, occlusion of the left atrial appendage may be a valuable choice [44].…”

Section: Atrial Fibrillationmentioning

confidence: 99%

Known–Unknowns in Geriatric Cardiology

Cocco¹,

Amiet²

2020

OBM Geriatrics

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The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly patients dealing with the prevention of arterial hypertension, bradycardic arrhythmias, atrial fibrillation, coronary artery syndromes, valve heart diseases, and heart failure. Progress in the field of medicine has rendered possible to treat lethal cardiac diseases in the extremely old patients. Nonetheless, data regarding the very old cardiac patients are limited, and it is dangerous to directly extrapolate the experience with the young patients to the old ones. • Preventive therapies are important in the old cardiac patients, although these therapies differ from those for young patients. • Very old patients with arterial hypertension benefit from antihypertensive treatment, although the therapeutic strategy of one-size-fits-all cannot be applied. • Elderly patients often require a cardiac pacemaker. In the case of patients with sinus node dysfunction, pacing modes capable of preserving atrioventricular synchrony are associated with a reduced incidence of atrial fibrillation. In the case of patients with atrioventricular block, the importance of synchronization is debatable. Implantable cardioverter-defibrillators may be used in very old patients, although a limited number of

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Left Atrial Appendages Occlusion: Current Status and Prospective

Cited by 22 publications

References 57 publications

Comparison Between Oral Anticoagulation and Left Atrial Appendage Occlusion in the Prevention of Stroke With Regard to Non-Valvular Atrial Fibrillation

Comparison Between Oral Anticoagulation and Left Atrial Appendage Occlusion in the Prevention of Stroke With Regard to Non-Valvular Atrial Fibrillation

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

Known–Unknowns in Geriatric Cardiology

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