LED photobiomodulation therapy combined with biomaterial as a scaffold promotes better bone quality in the dental alveolus in an experimental extraction model

Dalapria, Vanessa; Marcos, Rodrigo Labat; Bussadori, Sandra Kalil; Anselmo, Giuliana Giovinazzo; Benetti, Carolina; Santana, Ane Caroline Aparecida da Silva; Marinho, Natália Santana Reis; Pinto, Rayane Santos; Sales, Regiane Silva de; França, Lesley Silva de; Deana, Alessandro Melo

doi:10.1007/s10103-021-03407-w

Cited by 10 publications

(2 citation statements)

References 38 publications

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“…Among all bone grafts, cerabone ® was selected as biomaterial in the control group. Cerabone ® has been well studied to date in both preclinical animal studies [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ] and human clinical trials [ 57 , 58 , 59 ]. Socket preservation using cerabone ® has proven to be a reliable method to minimize the loss of bone volume at the extraction site [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Čandrlić

Tomas

Karl

et al. 2022

IJMS

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This study is the first histologic evaluation of an injectable biphasic calcium phosphate (IBCP) in humans six months after socket preservation according to the principles of guided bone regeneration. After tooth extraction, the alveolar ridge of 21 patients was augmented with IBCP (maxresorb® inject) in the test group, while 20 patients in the control group received a bovine xenograft (BX) (cerabone®). Six months after augmentation, a reentry procedure was performed to collect biopsies of regenerated bone for qualitative and quantitative histologic analysis. A total of 20 biopsies were taken for analysis. Qualitative histologic analysis showed complete integration of the biomaterial and no inflammatory tissue reaction, indicating the biocompatibility of the bone grafts and the surrounding tissue in both groups. Histomorphometric analysis showed comparable results in terms of newly formed bone (IBCP: 26.47 ± 14.71%, BX: 30.47 ± 16.39%) and residual biomaterial (IBCP: 13.1 ± 14.07%, BX: 17.89 ± 11.81%), with no significant difference found across groups (p > 0.05, Mann—Whitney U test). Statistical significance between groups was found in the result of soft tissue percentage (IBCP: 60.43 ± 12.73%, BX: 51.64 ± 14.63%, p = 0.046, Mann—Whitney U test). To conclude, IBCP and BX showed good osteoconductivity and biocompatibility with comparable new bone formation six months after alveolar ridge preservation.

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Section: Discussionmentioning

confidence: 99%

Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Čandrlić

Tomas

Karl

et al. 2022

IJMS

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“…Last but not least, laser photobiomodulation in combination with PRF demonstrated better bone healing than PRF alone in an iliac crest critical-sized bone defect sheep model ( Surmeli Baran et al, 2021 ). Photobiomodulation was also found to enhance bone formation of hydroxyapatite biomaterial in the dental alveolus in an experimental extraction rat model ( Dalapria et al, 2022 ). On the other hand, the effects of photobiomodulation on orthodontic treatment have started to attract attention ( Li J. et al, 2021 ; Yavagal et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Frontier Development of Alveolar Bone Grafting on Orthodontic Tooth Movement

Miao

Chang

Tanna

et al. 2022

Front. Bioeng. Biotechnol.

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Sufficient alveolar bone is a safeguard for achieving desired outcomes in orthodontic treatment. Moving a tooth into an alveolar bony defect may result in a periodontal defect or worse–tooth loss. Therefore, when facing a pathologic situation such as periodontal bone loss, alveolar clefts, long-term tooth loss, trauma, and thin phenotype, bone grafting is often necessary to augment bone for orthodontic treatment purposes. Currently, diverse bone grafts are used in clinical practice, but no single grafting material shows absolutely superior results over the others. All available materials demonstrate pros and cons, most notably donor morbidity and adverse effects on orthodontic treatment. Here, we review newly developed graft materials that are still in the pre-clinical stage, as well as new combinations of existing materials, by highlighting their effects on alveolar bone regeneration and orthodontic tooth movement. In addition, novel manufacturing techniques, such as bioprinting, will be discussed. This mini-review article will provide state-of-the-art information to assist clinicians in selecting grafting material(s) that enhance alveolar bone augmentation while avoiding unfavorable side effects during orthodontic treatment.

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The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Alam,

Karami,

Mohammadikhah

et al. 2024

Cell Biochemistry & Function

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The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.

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LED photobiomodulation therapy combined with biomaterial as a scaffold promotes better bone quality in the dental alveolus in an experimental extraction model

Cited by 10 publications

References 38 publications

Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Impact of Frontier Development of Alveolar Bone Grafting on Orthodontic Tooth Movement

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

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