Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus

Alavi, Mehran; Asare-Addo, Kofi; Nokhodchi, Ali

doi:10.3390/biomedicines8120580

Cited by 24 publications

(11 citation statements)

References 120 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…have been encapsulated in liposomal systems to date [1]. Furthermore, liposomes have been used as vaccine RNA fraction carriers (COVID-19 vaccine) [8].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications

et al. 2021

View full text Add to dashboard Cite

Liposomes continue to attract great interest due to their increased bioavailability in the body and because the substances encapsulated are protected while maintaining their effectiveness. The aim of this study is to obtain “giant” liposomes by lipid film hydration using a preparation formula with two different phospholipids, phosphatidylcholine (PC) and phosphatidylserine (PS). Firstly, the macro- and microscopic characterization, total phenols content and antioxidant capacity of the plant Stellaria media (L.) Vill. were assessed. Then, Stellaria media (L.) Vill. extract was encapsulated in both formulations (PCE and PSE) and the liposomes were characterized according to their morphology, size distribution and Zeta potential using optical microscopy and dynamic light scattering. The encapsulation efficiency (EE%) was determined using the Folin–Ciocalteu method and the values of both formulations were compared. PC and PCE liposomes with a diameter between 712 and 1000 nm and PS and PSE liposomes with a diameter between 58 and 1000 nm were obtained. The values EE% of Stellaria media (L.) Vill. extract for PCE and PSE were 92.09% and 84.25%, respectively.

show abstract

“…have been encapsulated in liposomal systems to date [1]. Furthermore, liposomes have been used as vaccine RNA fraction carriers (COVID-19 vaccine) [8].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Another group of target cells for vaccination purposes are dendritic cells (DC). These cells are covered with different receptors, which include lectins that recognize carbohydrate moieties present on many pathogens, and are involved in antigen capture and presentation [146,147]. Other dendritic cell receptors are the mannose receptor, DC-SIGN, DEC-205, and Langerin [148][149][150][151].…”

Section: Vaccine Targeting Strategiesmentioning

confidence: 99%

Methodical Design of Viral Vaccines Based on Avant-Garde Nanocarriers: A Multi-Domain Narrative Review

et al. 2021

View full text Add to dashboard Cite

The current health crisis caused by coronavirus 2019 (COVID-19) and associated pathogens emphasize the urgent need for vaccine systems that can generate protective and long-lasting immune responses. Vaccination, employing peptides, nucleic acids, and other molecules, or using pathogen-based strategies, in fact, is one of the most potent approaches in the management of viral diseases. However, the vaccine candidate requires protection from degradation and precise delivery to the target cells. This can be achieved by employing different types of drug and vaccine delivery strategies, among which, nanotechnology-based systems seem to be more promising. This entry aims to provide insight into major aspects of vaccine design and formulation to address different diseases, including the recent outbreak of SARS-CoV-2. Special emphasis of this review is on the technical and practical aspects of vaccine construction and theranostic approaches to precisely target and localize the active compounds.

show abstract

“…Encapsulated antiviral vaccines and agents in the cell membrane could be performed using functionalized liposomal and micellar formulations [180]. Tai et al [181] demonstrated that the liposomal composi-…”

Section: Liposomes Nanocompoundsmentioning

confidence: 99%

Application of nano compounds for the prevention, diagnosis, and treatment of SARS-coronavirus: A review

Saleh

Kumar

Sirakov

et al. 2021

jcc

View full text Add to dashboard Cite

Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus

Cited by 24 publications

References 120 publications

Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications

Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications

Methodical Design of Viral Vaccines Based on Avant-Garde Nanocarriers: A Multi-Domain Narrative Review

Application of nano compounds for the prevention, diagnosis, and treatment of SARS-coronavirus: A review

Contact Info

Product

Resources

About