Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression

Abreu, Ticiana Monteiro; Corpe, Fernanda Pires; Teles, Felipe Barros; Rivanor, Renata Line da Conceição; Sousa, Caren Nádia Soares de; Medeiros, Ingridy da Silva; Queiroz, Ismael Nilo Lino de; Figueira-Mansur, Janaina; Mota, Érika Freitas; Mohana‐Borges, Ronaldo; Macêdo, Danielle Silveira; Vasconcelos, Silvânia Maria Mendes; Júnior, José Eduardo Ribeiro Honório; Benevídes, Norma Maria Barros

doi:10.1016/j.algal.2022.102715

Cited by 11 publications

(8 citation statements)

References 58 publications

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“…Moreover, SfL at this dose did not alter the patterns of animal locomotion in open-field tests. Administration of SfL for one week did not exhibit visible signs of toxicity in mice [139,187].…”

Section: Proteins Peptides and Amino Acidsmentioning

confidence: 85%

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Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

Elbandy

2022

Molecules

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Functional foods include enhanced, enriched, fortified, or whole foods that impart health benefits beyond their nutritional value, particularly when consumed as part of a varied diet on a regular basis at effective levels. Marine sources can serve as the sources of various healthy foods and numerous functional food ingredients with biological effects can be derived from these sources. Microalgae, macroalgae, crustaceans, fungi, bacteria fish, and fish by-products are the most common marine sources that can provide many potential functional food ingredients including phenolic compounds, proteins and peptides, and polysaccharides. Neuroinflammation is closely linked with the initiation and progression of various neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease. Activation of astrocytes and microglia is a defense mechanism of the brain to counter damaged tissues and detrimental pathogens, wherein their chronic activation triggers neuroinflammation that can further exacerbate or induce neurodegeneration. Currently, available therapeutic agents only provide symptomatic relief from these disorders and no therapies are available to stop or slow down the advancement of neurodegeneration. Thereffore, natural compounds that can exert a protective effect against these disorders have therapeutic potential. Numerous chemical compounds, including bioactive peptides, fatty acids, pigments, alkaloids, and polysaccharides, have already been isolated from marine sources that show anti-inflammatory properties, which can be effective in the treatment and prevention of neuroinflammatory disorders. The anti-inflammatory potential of marine-derived compounds as functional food ingredients in the prevention and treatment of neurological disorders is covered in this review.

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Section: Proteins Peptides and Amino Acidsmentioning

confidence: 85%

“…Gabrielson is extensively found along the northeast coast of Brazil. Its lectin (SfL) is monomeric in nature and shows affinity toward the carbohydrate mannan [139,186].…”

Section: Proteins Peptides and Amino Acidsmentioning

confidence: 99%

Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

Elbandy

2022

Molecules

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“…These findings underscore the potential of marine algae-derived compounds as therapeutic agents for CNS disorders and call for clinical trials to validate their efficacy. Additionally, the paragraph briefly touches upon the cholinesterase inhibitory activity of certain plants, suggesting a potential avenue for the symptomatic treatment of Alzheimer's disease [66,105].…”

Section: Evidence Of Neuroprotection In Preclinical Studiesmentioning

confidence: 99%

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Pereira,

Valado

2024

OBM Neurobiol

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This review explores the potential of compounds derived from red algae (Rhodophyta) as promising neuroprotective agents for treating neurodegenerative disorders. Red algae, abundant in marine environments, contain bioactive compounds with diverse chemical structures and functionalities. Sulfated polysaccharides, primarily agar and carrageenans, stand out as the predominant and widely utilized compounds derived from red algae. Additionally, red algae harbor a spectrum of potential molecules such as essential fatty acids, phycobiliproteins, vitamins, minerals, and secondary metabolites. Extensive research has highlighted the diverse biological activities exhibited by these compounds, including anti-oxidative and anti-inflammatory properties. These compounds show various biological activities that have garnered interest in their therapeutic potential for neurodegenerative diseases. This comprehensive review aims to summarize the current knowledge regarding the extraction, characterization, mechanisms of action, and therapeutic applications of Rhodophyta-derived compounds in the context of neuroprotection and treatment of neurodegenerative disorders.

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“…Lectins extracted from macroalga have gained attention owed to their great range of bioactivities. Antimicrobial peptides isolated from the algae Tetraselmis suecica (Kylin) were efficient against the gram-positive and Gram-negative bacterias (Abreu et al 2022 ). An antibacterial peptides SP-1 isolated from Spirulina platensis is reported to be non-toxic by haemolysis.…”

Section: Antibacterial Compound Isolated From Algaementioning

confidence: 99%

Antimicrobial therapeutics isolated from algal source: retrospect and prospect

et al. 2022

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In the last few decades, attention on new natural antimicrobial compounds has arisen due to a change in consumer preferences and the increase in the number of resistant microorganisms. Algae are defined as photosynthetic organisms that demonstrate a wide range of adaptability to adverse environmental conditions like temperature extremes, photo-oxidation, high or low salinity, and osmotic stress. Algae are primarily known to produce large amounts of secondary metabolite against various kinds of pathogenic microbes. Among these algae, micro and microalgae of river, lake, and algae of oceanic origin have been reported to have antimicrobial activity against the bacteria and fungi of pathogenic nature. Various polar and non- polar extracts of micro- and macro algae have been used for the suppression of these pathogenic fungi. Apart from these, certain algal derivatives have also been isolated from these having antibacterial and antifungal potential. Among the bioactive molecules of algae, polysaccharides, sulphated polysaccharides, phyco-cyanobilins polyphenols, lectins, proteins lutein, vitamin E, B 12 and K 1 , peptides, polyunsaturated fatty acids and pigments can be highlighted. In the present review, we will discuss the biological activity of these derived compounds as antifungal/ antibacterial agents and their most promising applications. A brief outline is also given for the prospects of these isolated phytochemicals and using algae as therapeutic in the dietary form. We have also tried to answer whether alga-derived metabolites can serve as potential therapeutics for the treatment of SARS-CoV-2 like viral infections too.

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Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression

Cited by 11 publications

References 58 publications

Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

Red Algae Compounds: Potential Neuroprotective Agents for Neurodegenerative Disorders

Antimicrobial therapeutics isolated from algal source: retrospect and prospect

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