Lectin histochemical characterisation of the porcine small intestine around weaning

Hedemann, Mette Skou; Højsgaard, Søren; Jensen, Bent Borg

doi:10.1016/j.rvsc.2006.06.007

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Weaning stress has been reported to injures secretory cells (mucus-producing goblet cells) differentiation and thus resulted in decreased mucins secretion ( 41 , 96 ). For instance, Hedemann and Jensen ( 97 ) indicated that early weaning would not only lead to a decrease in intestinal mucin secretion but also change the glycosylation pattern of mucin, thereby weakening the intestinal chemical barrier function and increasing the probability of intestinal infection. Similarly, Yang et al.…”

Section: Weaning Stress and Intestinal Barrier Functionmentioning

confidence: 99%

“…First, weaning stress disrupts the intestinal mucosal mechanical barrier by reducing the expression of tight junction proteins ( 28 , 30 , 83 – 85 ), which makes it easier for bacteria and toxins to break through the intestinal mucosal barrier, and cause the release of a variety of cellular inflammatory factors, thereby leading to the occurrence of intestinal inflammation ( 156 ). Second, weaning stress disrupts the intestinal chemical barrier by inhibiting goblet cell differentiation and mucins secretion ( 41 , 97 ), and decreased mucins secretion further disrupts the intestinal mechanical barrier ( 99 ), immune barrier ( 100 ), and microbial barrier ( 98 ). Third, weaning stress disrupts the intestinal chemical barrier by promoting the secretion of inflammatory factors ( 13 , 14 , 28 , 30 , 117 – 120 ), while pro-inflammatory cytokines including IL-1β, TNF-α, and IFN-γ, have important intestinal TJ barrier-modulating actions ( 157 , 158 ).…”

Section: Weaning Stress and Intestinal Barrier Functionmentioning

confidence: 99%

See 1 more Smart Citation

Weaning stress and intestinal health of piglets: A review

Tang

Xiong²,

Fang³

et al. 2022

Front. Immunol.

106

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Weaning is considered to be one of the most critical periods in pig production, which is related to the economic benefits of pig farms. However, in actual production, many piglets are often subjected to weaning stress due to the sudden separation from the sow, the changes in diet and living environment, and other social challenges. Weaning stress often causes changes in the morphology and function of the small intestine of piglets, disrupts digestion and absorption capacity, destroys intestinal barrier function, and ultimately leads to reduced feed intake, increased diarrhea rate, and growth retardation. Therefore, correctly understanding the effects of weaning stress on intestinal health have important guiding significance for nutritional regulation of intestinal injury caused by weaning stress. In this review, we mainly reviewed the effects of weaning stress on the intestinal health of piglets, from the aspects of intestinal development, and intestinal barrier function, thereby providing a theoretical basis for nutritional strategies to alleviate weaning stress in mammals in future studies.

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Section: Weaning Stress and Intestinal Barrier Functionmentioning

confidence: 99%

Section: Weaning Stress and Intestinal Barrier Functionmentioning

confidence: 99%

Weaning stress and intestinal health of piglets: A review

Tang

Xiong²,

Fang³

et al. 2022

Front. Immunol.

106

View full text Add to dashboard Cite

show abstract

“…Several mammal studies have indicated that the mucin glycosylation varies according to animal species, anatomical region, position along crypt-villus axis, pathological conditions, and dietary habits (Hedemann et al, 2007). However, little attention has been paid to the age-dependent changes in mucin secretion and composition.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the morphology and histochemistry of the duodenum of the coypu (Myocastor coypus bonariensis) during its prenatal and postnatal development

Hoz

Eyheramendy²,

Felipe³

et al. 2016

Tissue and Cell

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“…The secretion of intestinal MUCs and the activity of intestinal digestive enzymes in piglets decreases during weaning, resulting in a weakened chemical barrier function and an enhancement of intestinal susceptibility [67,68]. C. butyricum can effectively regulate intestinal chemical barrier function through the following mechanisms:…”

Section: Clostridium Butyricum and Intestinal Chemical Barriermentioning

confidence: 99%

Probiotic Roles of Clostridium butyricum in Piglets: Considering Aspects of Intestinal Barrier Function

Tang

2024

Animals

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China, as the global leader in pork production and consumption, is faced with challenges in ensuring sustainable and wholesome growth of the pig industry while also guaranteeing meat food safety amidst the ban on antibiotics usage in animal feed. The focus of the pig industry lies in guaranteeing piglet health and enhancing overall production performance through nutrition regulation. Clostridium butyricum (C. butyricum), a new type of probiotic, possesses characteristics such as heat resistance, acid resistance, and bile-salt tolerance, meaning it has potential as a feed additive. Previous studies have demonstrated that C. butyricum has a probiotic effect on piglets and can serve as a substitute for antibiotics. The objective of this study was to review the probiotic role of C. butyricum in the production of piglets, specifically focusing on intestinal barrier function. Through this review, we explored the probiotic effects of C. butyricum on piglets from the perspective of intestinal health. That is, C. butyricum promotes intestinal health by regulating the functions of the mechanical barrier, chemical barrier, immune barrier, and microbial barrier of piglets, thereby improving the growth of piglets. This review can provide a reference for the rational utilization and application of C. butyricum in swine production.

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Lectin histochemical characterisation of the porcine small intestine around weaning

Cited by 8 publications

References 23 publications

Weaning stress and intestinal health of piglets: A review

Weaning stress and intestinal health of piglets: A review

Comparative analysis of the morphology and histochemistry of the duodenum of the coypu (Myocastor coypus bonariensis) during its prenatal and postnatal development

Probiotic Roles of Clostridium butyricum in Piglets: Considering Aspects of Intestinal Barrier Function

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