Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients

Mauri, Andreana De; Chiarinotti, Doriana; Andreoni, Stefano; Molinari, Gian Lorenzo; Conti, Novella; Leo, Martino De

doi:10.1099/jmm.0.059535-0

Cited by 35 publications

(34 citation statements)

References 19 publications

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“…To date, literature on L. adecarboxylata bacteremia has been limited to a few case reports, mostly documented as polymicrobial infections [4, 16]. The majority of these cases have been reported in immunocompromised patients or those with longstanding central venous access.…”

Section: Discussionmentioning

confidence: 99%

“…This is a ubiquitous, aerobic, motile, gram-negative bacillus, which also inhabits the human gastrointestinal (GI) tract [3]. Worldwide, infection with this rarely pathogenic microorganism has been limited to a small number of case reports [4]; of these, only a few reports implicate the GI tract as the focus of infection [5, 6]. We describe a case of L. adecarboxylata bacteremia in a patient presenting with bloody diarrhea who was subsequently diagnosed with inflammatory bowel disease (IBD).…”

Section: Introductionmentioning

confidence: 99%

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Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Kashani

Chitsazan

Che

et al. 2014

Case Reports in Gastrointestinal Medicine

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Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Leclercia adecarboxylata is a ubiquitous, aerobic, motile, gram-negative bacillus. The human GI tract is known to harbor this rarely pathogenic microorganism. There are only a few case reports of bacteremia with this microorganism; the majority are either polymicrobial or associated with immunocompromised patients. We describe a case of monomicrobial L. adecarboxylata bacteremia in a 43-year-old female who presented with bloody diarrhea. Colonoscopy revealed diffuse colonic mucosal inflammation with numerous ulcers, and histopathology revealed crypt abscesses. Following an episode of rectal bleeding, two sets of blood cultures grew L. adecarboxylata, which was treated with intravenous ceftriaxone. After a complicated hospital course, she was eventually diagnosed with ulcerative colitis and enteropathic arthritis, treated with intravenous methylprednisolone, mesalamine, and infliximab which resulted in resolution of her symptoms. In our previously immunocompetent patient, derangement of the gut mucosal barrier was the likely cause of bacteremia, yet performing endoscopic intervention may have contributed to bacterial translocation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Kashani

Chitsazan

Che

et al. 2014

Case Reports in Gastrointestinal Medicine

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“…Leclercia adecarboxylata is a Gram-negative opportunistic pathogen mostly collected from environmental sources (1, 2). It may rarely be isolated from clinical samples, mostly from inmunocompromised patients, but rare infections in immunocompetent patients have also been described, however, they are often associated with polymicrobial flora (1, 3, 4).…”

Section: Genome Announcementmentioning

confidence: 99%

“…It may rarely be isolated from clinical samples, mostly from inmunocompromised patients, but rare infections in immunocompetent patients have also been described, however, they are often associated with polymicrobial flora (1, 3, 4). Therefore, the real implication of L. adecarboxylata in human infections is still unclear.…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of NDM-1-Producing Leclercia adecarboxylata

et al. 2017

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“…Bazı çalışmalarda yenidoğan sepsis nedeni olduğu bildirilmiştir 10,11 . Bizim olgumuzda olduğu gibi hemodiyaliz hastalarında s antral venöz kateter ilişkili bakteriyemi olguları da bildirilmiştir 3,12 . Ayrıca malignensi olan hastalarda santral venöz kateter ilişkili bakteriyemi bildirilmiştir 13 .…”

Section: Olgu Sunumuunclassified

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

Şafak¹,

Sezer²,

Yenigun³

2017

BSBD

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bsbd@balikesir.edu.tr www.bau-sbdergisi.com ÖZET Öncel eri Enteri k grup 41 veya Eschrechia adecarboxylata ol a ra k bi l i nen mi kroorga ni zma , 1962'den i tibaren Leclercia adecarboxylata ol arak adlandırılmıştır. Çeşitli çevresel kaynaklarda bul unan mikroorganizmanın kan, idrar, balgam, ya ra gibi farklı klinik örneklerden i zole edil di ği bi l dirilmiştir. Bu olgu, bilgilerimize göre ül kemi zden bi l di ri l en L. adecarboxylata'ya ba ğl ı i l k enfeks i yon ol ma s ı nedeni yl e s unul muştur.Son dönem kroni k böbrek yetmezl i ği ol a n di ya l i ze gi ren 85 ya şında ki erkek ha s ta , a teş şi ka yetiyle acil servi se başvurmuştur. La boratuva r tetkiklerinde beya z küre normal, CRP, üre ve krea tinin yüksek olarak ölçülmüştür. Ya tırılarak tedavisi planlanan hastadan kateter ve peri fer da mar yol undan kan kültürü alınmıştır. Ampirik olarak s eftri a ks on teda vi s i ne ba şl a nmıştır. Ka teterden alınan kan kültürü, perifer damar yol undan alınan kan kültüründen dört s a a t önce ol mak üzere her iki örnekten de BacT/Alert 3D (bioMerieux, Fransa) kan kültür ci hazında pozitif s i nyal alınmıştır. L. adecarboxylata ol arak tanımlanan bakteri a mikasin, gentamisin, s eftazidim, s eftriakson, siprofloksasin, i mipenem duya rl ı, a moks i s i l i n -kl a vul a ni k a s i t di rençl i ol a ra k bul unmuştur. Ka teterden alınan kan kültürü örneği dört s aat önce pozitiflik verdiğinden kateter i l i şki l i L. adecarboxylata'ya ba ğl ı ba kteri yemi ta nıs ı konul muştur. Anti bi yoti k duya rl ıl ık ra poruna göre s eftri a ks on duya rl ı bul unduğunda n teda vi 15 güne ta ma ml a nmıştır.E. coli'ye benzerliği nedeniyle s ıklıkla a tlanabileceğinden özel l i kl e fos fomi s i n di rençl i E. coli i zolatlarında, ileri biyokimyasa l a na l i zl erl e a yrımının ya pıl ma s ı gerekti ği düşünül müştür.Anahtar Kelimeler: Lecl erci a a deca rboxyl a ta , ka teter ka yna kl ı, ba kteri yemi SUMMARYThe mi croorganism known as Enteri c group 41 or Escherichia adecarboxylatain the pa s t wa s na med as Leclercia adecarboxylata s i nce 1962. It has been reported that the mi croorga ni s m, whi ch is present i n va rious environmenta l res ources wa s i s ol a ted from di fferent cl i ni ca l s pecimens s uch a s blood, urine, sputum and wound. This case report was presented, beca us e of the fa ct that i t is the first reported infection caused by L. adecarboxylata i n our country a s fa r a s we know.The ma le patient aged 85 yea rs old on di a l ys i s wi th end s ta ge chroni c rena l di s ea s e wa s a dmitted to emergency s ervice wi th complaint of fever. The laboratory a nalysis revealed hi gh l evels of CRP, urea a nd creatinin and normal levels of white blood cel l count. Bl ood cul tures were obtained vi a the catheter and periphera l va s cul a r a cces s , from the pa ti ent who wa s hos pitalised to plan the treatment. Ceftriaxone was s tarted as a n empi ri ca l trea tment. Both bl ood culture s amples were positive signalling i n Bact/Alert 3D (Biomeriuex, Fra nce) i n whi ch the one obtained f...

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Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients

Cited by 35 publications

References 19 publications

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Leclercia adecarboxylataBacteremia in a Patient with Ulcerative Colitis

Draft Genome Sequence of NDM-1-Producing Leclercia adecarboxylata

Catheter-Related Bacteremia Caused By Leclercia adecarboxylata: Case Report

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