Lecithin doped electrospun poly(lactic acid)-thermoplastic polyurethane fibers for hepatocyte viability improvement

Recent Advances in Bioplastics: Application and Biodegradation

“…The successful production of neurotrophic growth factor allowed PC12 cells to have a sustained neurite outgrowth. Liu and co-workers [160] focused on the in vitro growth of hepatocytes and saw that a lecithin modified PLA-polyurethane composite allowed HePG2 cells to grow more sustainably compared to growth in culture plates alone. A more peculiar approach was reported by Paolini and colleagues [161], wherein a PLA polymer was coated with a polyamidoamine bound miRNA to transfect genes to plated HeLa cells.…”

Fabrication of green poly(vinyl alcohol) nanofibers using natural deep eutectic solvent for fast-dissolving drug delivery

“…PVA-DES-honey/ASA nanobers were prepared by electrospinning according to reported procedures. [21][22][23] An electrospinning solution of PVA (10.5%, w/v), an electrospinning solution of PVA (9%, w/v) and DES (5%, w/v), an electrospinning solution of PVA (9%, w/v), DES (5%, w/v) and ASA (5%, w/v), and an electrospinning solution of PVA (8%, w/v), DES (5%, w/v) and honey (5%, w/v) were sprayed from a 10 mL plastic syringe at a rate of 0.75 mL h À1 . A voltage of 23 kV is applied to the needle, where the positive high voltage was 18 kV and the negative high voltage was 5 kV.…”

“…8,24 2.2.5 Tensile properties. Mechanical properties of the PVA, PVA-DES, PVA-DES-honey, PVA-DES-ASA nanobers were investigated according to reported procedures, 22,26 using a universal tensile testing machine (DDL10, EDC-controller, Germany and China) with a crosshead rate of 5 mm min À1 . The sample was stabilized on a frame with a gauge length of 10 mm, and equipped with a 100 N load cell.…”

Application of blocking and immobilization of electrospun fiber in the biomedical field

“…The addition of the thermoplastic material PU improves the brittleness of PLA, and further promotes the growth and proliferation of hepatocytes. 52 In addition, materials for bone tissue, cartilage tissue and vascular transplantation can also be prepared. da Silva et al 53 used PLA and PVA as materials to prepare the nanober scaffold with a core-shell structure by electrospinning as the carrier of the BMP-2 protein, and applied to the recovery of alveolar bone tissue.…”