Lecithin: cholesterol acyltransferase in Down's syndrome

Lacko, Andras G.; Hayes, J. D.; McConathy, Walter J.; Lacko, Irene; Redheendran, R

doi:10.1016/0009-8981(83)90241-3

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…Adults with Down syndrome and mild to moderate MR residing in community settings primarily possess elevated CVD risk factors and components of the metabolic syndrome, which include hyperinsulinemia, abdominal obesity, and hypertri-glyceridemia, and low HDL cholesterol levels [Nishidi et al, 1977;Salo et al, 1979;Pueschel et al, 1992;Draheim et al, 2002a;Braunschweig et al, 2004]. Similar cholesterol levels between adults with MR and Down syndrome along with higher triglyceride levels in adults with Down syndrome have been consistently reported [Nishidi et al, 1977;Salo et al, 1979;Lacko et al, 1983;Pueschel et al, 1992].…”

Section: Cardiovascular Disease In Persons With Down Syndromementioning

confidence: 89%

Cardiovascular disease prevalence and risk factors of persons with mental retardation

Draheim

2006

Ment. Retard. Dev. Disabil. Res. Rev.

107

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This paper reviews the recent literature on cardiovascular disease (CVD) prevalence, CVD-related mortality, physiological CVD risk factors, and behavioral CVD risk factors in adults with mental retardation (MR). The literature on the potential influences of modifiable behavioral CVD risk factors and the physiological CVD risk factors are also reviewed. Adults with mild to moderate MR residing in community settings appear to have an elevated disease prevalence, elevated CVD-related mortality, more adverse physiological CVD risk factors, and elevated behavioral risk compared to others with and without MR. Preliminary evidence supports the benefits of participating in the recommended physical activity levels and consuming the recommended diets to reduce the risk for CVD. The lack of large-scale longitudinal or experimental research indicates a gap in the research. The development of research-based, appropriate, primary prevention programs and intervention strategies aimed at lowering the risk for CVD is highly recommended. Programs should focus on educating individuals with MR along with direct care providers and family members on the importance of appropriate dietary concepts, physical activity habits, and regular health screenings by physicians. Programs should be individualized to regional and cultural issues.

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Section: Cardiovascular Disease In Persons With Down Syndromementioning

confidence: 89%

Cardiovascular disease prevalence and risk factors of persons with mental retardation

Draheim

2006

Ment. Retard. Dev. Disabil. Res. Rev.

107

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“…Down syndrome patients are characterized by reduced cholesterol esterification in plasma [23]. They also have specific pattern of the liver sterol regulatory element binding protein (SREBP) activation, and sterol-independent maturation of SREBP.…”

Section: Cholesterol and Down Syndromementioning

confidence: 99%

Cholesterol homeostasis failure as a unifying cause of synaptic degeneration

Koudinov

Koudinova

2005

Journal of the Neurological Sciences

109

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“…Individuals with DS present several metabolic lipid abnormalities [7,[10][11][12][13][14][15], although serum lipoprotein profiles cannot completely explain the lower prevalence of cardiovascular disease. Studies have shown that younger individuals with DS have lower high-density lipoprotein (HDL) levels [11,13,14], altered lecithin:cholesterol acyltransferase (LCAT) activity [16] and HDL component apolipoprotein A-I (ApoA-I) levels [12]. However, the causative role of HSA21 genes on this phenotype remains unknown.…”

Section: Introductionmentioning

confidence: 98%