Leaves of Andrographis Paniculata Is an Antioxidant and Anticancer Agent

Therasa, S. Annai; Sobiya, G.; Parimala, Mabel

doi:10.22159/ajpcr.2020.v13i8.37014

Cited by 6 publications

(5 citation statements)

References 21 publications

(21 reference statements)

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“…Total flavonoids were analyzed using a colorimetric method with minor modifications according to Chang et al, 2017. Quercetin was used to construct a calibration curve [19]. About 1mg of quercetin was dissolved in 1ml of distilled water and diluted sequentially; in another test tube, the extract solution was diluted as distilled water.…”

Section: Test For Phenols and Tanninsmentioning

confidence: 99%

Phytochemical Screening, Antioxidant and Antimicrobial Activity of Andrographis paniculata

Bhati¹,

Gupta²,

Jatav³

et al. 2023

azb

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As a magician in India, Andrographis paniculata is called Crete or the King of Bitters because of its bitter taste. It is known for ethnic medicine to treat diseases, inflammation, cold, fever, snake bite, diarrhea, dysentery, jaundice, kidney disease and antioxidant. This study was done by preparing the solution in ethanol for the whole plant. Phytochemical analysis was performed due to the presence of important drugs as well as phenols, tannins, flavonoids, saponins, glycosides, steroids, terpenoids and alkaloids. It has been reported that these secondary metabolites have many biological and therapeutic properties, so it is expected that this species has many medicinal applications. It is rich in phenols, flavonoids and alkaloids and exhibits antioxidant and antimicrobial properties (including antibacterial and antifungal). This study was conducted using the agar disc diffusion method, in which the extract shows antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans, and may be the ingredients used in the method. The source of the antibiotic depends on the concentration. In addition, by several free-flow studies, the antioxidant capacity of paniculata plants has been confirmed. Therefore, they are also effective antioxidants and have anti-cancer properties.

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Section: Test For Phenols and Tanninsmentioning

confidence: 99%

Phytochemical Screening, Antioxidant and Antimicrobial Activity of Andrographis paniculata

Bhati¹,

Gupta²,

Jatav³

et al. 2023

azb

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show abstract

“…The plant has been traditionally used to treat fever, cough, skin diseases, ulcers, breathing difficulties, worms and wound healing (Rajalakshmi et al 2016;Theresa et al 2020). The use of the whole plant has been seen for poisonous stings, dysentery, malaria, influenza and respiratory infections, while leaf extract is used as a remedy for infectious diseases, loss of appetite, diarrhoea etc.…”

Section: Medicinal Uses Of Andrographis Paniculatamentioning

confidence: 99%

Anticancer Compounds from Selected Medicinal Plants: An Update

2022

Medicinal Plants: Ethnomedicine, Pharmacognosy and Therapeutic Values

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Globally cancer is one of the leading causes of mortality. Although, rapid progression and advancement in treatment have been made to combat this life-threatening disease. Conventional therapies like chemotherapy and radiation therapy have several adverse side effects on healthy cells, therefore, a novel alternative and effective treatment regime is required to treat cancer. Currently, the benefits of using medicinal plant-derived products over synthetic medicine have significantly increased in the field of healthcare. Several medicinal plants and their bioactive compounds have shown to possess potent anti-cancer properties in vitro and in vivo. Additionally, they are less toxic, very effective and, safe when administered in cancer patients. Some of the well-established anti-tumor compounds include vinblastine, curcumin, vincristine, podophyllotoxin, taxol, orientin, camptothecin vinflunine ditartrate, anhydrovinblastine, poliglumex, combretastatins, and triptolide. Many of them are in clinical trial, only a few have been clinically approved. This chapter

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“…Andrographis paniculata , commonly known as “Hempedu Bumi” in Malaysia, is a popular traditional medicine used extensively across Asia [ 30 – 32 ]. This medicinal plant contains diverse phytochemicals including labdane diterpenoid lactones, flavonoids and miscellaneous phytochemicals that possess a wide spectrum of pharmacological properties and biological applications, such as anti-microbial [ 33 , 34 ], antioxidant [ 35 , 36 ], antiangiogenic [ 37 , 38 ], anti-diabetic [ 39 ], anti-inflammatory and immunostimulatory [ 40 – 42 ]. Owing to its high antioxidant capacity, A. paniculata extract has also recently been exploited to synthesize different types of nanoparticles which assists in the removal of potentially harmful by-products while also aiding in nanoparticle fine-tuning [ 43 – 45 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on 3 fatty acid synthase expression on breast cancer cells

Johari,

Sapi’i,

Jiunn Hieng

et al. 2024

BioMedicine

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Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid biosynthesis pathway has been identified to be overexpressed in breast cancer. This overexpression has been affiliated with poor prognosis and resistance to chemotherapeutics. Consequently, FASN has come into focus as an appealing potential target for breast cancer treatment. Available FASN inhibitors, however, are unstable and have been correlated with adverse side effects. Objective This present study aims to investigate the potential of Andrographis paniculata ethanolic crude extract (AP) as a potent FASN inhibitor in breast cancer cells. Materials & methods This study used MTT assay and flow cytometry analysis to measure cell viability and apoptosis following AP treatment (0–500 μg/mL). Furthermore, FASN protein expression was evaluated using immunocytochemistry whereas lipid droplet formation was quantified using Oil Red O staining. Literature-based identified AP phytochemicals were subjected to the prediction of molecular docking and ADMET properties. Results This study demonstrated that AP significantly reduced cell viability while inducing apoptosis in breast cancer cells. In addition, for the first time, exposure to AP was demonstrated to drastically reduce intracellular FASN protein expression and lipid droplet accumulation in EMT6 and MCF-7 breast cancer cells. Docking simulation analysis demonstrated AP phytochemicals may have exerted an inhibitory effect by targeting the FASN Thioesterase (TE) domain similarly to the known FASN inhibitor, Orlistat. Moreover, all AP phytochemicals also possessed drug-likeness properties which are in accordance with Lipinski’s rule of five. Conclusions These results highlight the potential of A. paniculata ethanolic crude extract as a FASN inhibitor and hence might have the potential to be further developed as a potent chemotherapeutic drug for breast cancer treatment.

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Leaves of Andrographis Paniculata Is an Antioxidant and Anticancer Agent

Cited by 6 publications

References 21 publications

Phytochemical Screening, Antioxidant and Antimicrobial Activity of Andrographis paniculata

Phytochemical Screening, Antioxidant and Antimicrobial Activity of Andrographis paniculata

Anticancer Compounds from Selected Medicinal Plants: An Update

In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on 3 fatty acid synthase expression on breast cancer cells

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