Learning skills and academic performance in children and adolescents with absence epilepsy

Talero-Gutiérrez, Claudia; Sánchez-Torres, Jenny Marcela; Vélez-van-Meerbeke, Alberto

doi:10.1016/j.nrleng.2013.10.021

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…To further explore the interaction between miR‐181b and TLR4, as well as its underlying mechanism in epilepsy, we gave an injection of miR‐181b agomir or TAK‐242 (TLR4 inhibitor) to KA‐induced epileptic juvenile rats, and our findings demonstrated that the spatial memory abilities of rats, as a kind of advanced neural activity of brain, which was an important element of both cognition and intelligence structure, whereas many epileptic patients have severe cognitive impairment, were significantly improved . Besides, miR‐181b and TAK‐242 in this work could significantly inhibit the cell apoptosis in hippocampus tissue of KA‐induced epileptic rats, with down‐regulation of Bax and cleaved caspases‐3 expressions but upregulation of Bcl‐2.…”

Section: Discussionmentioning

confidence: 64%

“…,37 Besides, miR-181b and TAK-242 in this work could significantly inhibit the cell apoptosis in hippocampus tissue of KA-induced epileptic rats, with down-regulation of Bax and cleaved caspases-3 expressions but upregulation of Bcl-2. As we know, SE seizure may result in morphological changes of hippocampal neurons, such as cellular swelling, rupture, karyopyknosis or karyolysis, apoptosis, and autophagic corpuscle formation 38.…”

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confidence: 55%

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MiR‐181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid‐induced epilepsy via targeting TLR4

et al. 2018

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Section: Discussionmentioning

confidence: 64%

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confidence: 55%

MiR‐181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid‐induced epilepsy via targeting TLR4

et al. 2018

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“…Assessed using the Battery of General and Differential Aptitudes for schoolchildren aged 6‐8 years (BADyG E1). This battery has shown an excellent reliability (Cronbach's α = 0.92 to general intelligence), and strong predictive validity between general intelligence and scores in Language and Mathematics ( r = 0.609; P = 0.001; r = 0.687; P = 0.001, respectively) and is the most commonly used battery in schools and research studies in Spain . This tool consisted of 162 items grouped in different tests that allow assessing some specific cognitive dimensions: logical reasoning (ability to establish analogy relations between concepts, flexibility to perform numerical‐verbal problems, and inductive reasoning), the verbal factor (ability to discover relationships between concepts and verbal comprehension), the numerical factor (ability to solve numerical problems safely and quickly), and the spatial factor (ability to make spatial turns with geometric figures and their inductive reasoning); and global computation of general intelligence (calculated as the sum of the four specific dimensions).…”

Section: Methodsmentioning

confidence: 99%

Impact of a multicomponent physical activity intervention on cognitive performance: The MOVI‐KIDS study

Sánchez‐López

Cavero‐Redondo

Álvarez‐Bueno

et al. 2019

Scandinavian Med Sci Sports

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Introduction:This study examined the impact of a multicomponent physical activity (PA) intervention (MOVI-KIDS) on improving cognition in schoolchildren. This paper also analyzed the mediator role of motor fitness between MOVI-KIDS and cognition. Methods: Propensity score analysis of data from a cluster randomized controlled trial (MOVI-KIDS study). This analysis including 240 5-7 years old children from nine schools in the provinces of Cuenca and Ciudad Real, Spain. MOVI-KIDS program consisted of: (a) three weekly after-school sessions of recreational non-competitive PA lasting 60 minutes during one academic year, (b) educational materials for parents and teachers, and (c) school playground modifications. Changes in cognition (logical reasoning, verbal factor, numerical factor, spatial factor, and general intelligence) were measured. A propensity score cross-cluster matching procedure and mediation analysis (Hayes's PROCESS macro) were conducted. Results: All cognitive variables pre-post mean changes were significantly higher (P ≤ 0.05) in children from intervention schools than those from control schools (effect size ranged from 0.33 to 1.48). The effect of the intervention on the spatial factor and general intelligence was partially mediated by motor fitness (indirect effect = 0.92, 95% CI: 0.36; 1.65; and indirect effect = 1.21, 95% CI: 0.06; 2.62, respectively). Conclusions:This study shows that a one-school-year multicomponent intervention consisting of a recreational non-competitive PA program, educational materials for parents and teachers, and school playground modifications improved the cognition of first-grade children. Further, our results suggest that the effect of the intervention on cognition was mediated by changes in motor fitness. K E Y W O R D S children, cognition, exercise, fitness, randomized controlled trial | 767 SÁNCHEZ-LÓPEZ Et aL. SUPPORTING INFORMATIONAdditional supporting information may be found online in the Supporting Information section at the end of the article.

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Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

et al. 2019

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Cognition in absence epilepsy (AE) is generally considered undisturbed. However, reports on cognitive deficits in AE in recent years have suggested otherwise. This review systematically assesses current literature on cognitive performance in children with AE. A systematic literature search was performed in Pubmed, Embase, Cochrane and Web of Science. All studies reporting on cognitive performance in children with AE were considered. In total 33 studies were eligible for inclusion. Neuropsychological tests were classified into the following domains: intelligence; executive function; attention; language; motor & sensory-perceptual examinations; visuoperceptual/visuospatial/visuoconstructional function; memory and learning; achievement. Random-effect meta-analyses were conducted by estimating the pooled mean and/or pooling the mean difference in case-control studies. Full-scale IQ in children with AE was estimated at 96.78 (95%CI:94.46–99.10) across all available studies and in case-control studies IQ was on average 8.03 (95%CI:-10.45- -5.61) lower. Verbal IQ was estimated at 97.98 (95%CI:95.80–100.16) for all studies and 9.01 (95%CI:12.11- -5.90) points lower in case-control studies. Performance IQ was estimated at 97.23 (93.24–101.22) for all available studies and 5.32 (95%CI:-8.27–2.36) points lower in case-control studies. Lower performance was most often reported in executive function (cognitive flexibility, planning, and verbal fluency) and attention (sustained, selective and divided attention). Reports on school difficulties, neurodevelopmental problems, and attentional problems were high. In conclusion, in contrast to common beliefs, lower than average neurocognitive performance was noted in multiple cognitive domains, which may influence academic and psychosocial development.Electronic supplementary materialThe online version of this article (10.1007/s11065-019-09419-2) contains supplementary material, which is available to authorized users.

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Learning skills and academic performance in children and adolescents with absence epilepsy

Cited by 4 publications

References 23 publications

MiR‐181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid‐induced epilepsy via targeting TLR4

MiR‐181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid‐induced epilepsy via targeting TLR4

Impact of a multicomponent physical activity intervention on cognitive performance: The MOVI‐KIDS study

Towards a Better Understanding of Cognitive Deficits in Absence Epilepsy: a Systematic Review and Meta-Analysis

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