Spatial and urban planning processes regarding border cooperation have reached unprecedented levels in recent decades, not only due to their potential for territorial integration, i.e., infrastructure construction and planning activities worldwide. Bearing in mind the European project, for a united and strong network of nations, this scenario is more evident in European territories. In this regard, through multivariated analyzes of city cooperation on European border areas, it is possible to identify the factors that influence the territorial success and also a sustainable regional development and even their effects over the urban agglomerations. From the identified factors, the study pointed out one that is common to all cases: connectivity-movement between cities.