Learning and memory in a rat model of social jetlag that also incorporates mealtime

Lewis, Leanna M.; Deibel, Scott H.; Cleary, Jillian; Viguers, Kayla; Jones, Karen; Skinner, Darlene M.; Hallett, Darcy; Thorpe, Christina M.

doi:10.1080/09291016.2020.1716557

Cited by 5 publications

(9 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent report, in which day length and photoperiod varied day to day for 7 days, speaks to this ( Lewis et al, 2020 ). The male Long-Evans rats failed to entrain to this schedule and free-ran at ∼24.5 h. Crucially, as in Zelinski et al (2014b) , the lighting schedule was introduced in between acquisition and retention testing.…”

Section: Resultsmentioning

confidence: 95%

“…In accordance with Zelinski et al (2014b) , these rats also displayed impaired retention in the water task. This is surprising given that the Lewis et al (2020) manipulation is very different as period and photoperiod change from day to day. Importantly though, in both paradigms animals free-run in a light dark cycle that they cannot entrain to.…”

Section: Resultsmentioning

confidence: 99%

“…Rats fail to entrain to T21 schedules and exhibit free-running behavior in a variety of photoperiods: 12L:9D ( Devan et al, 2001 ; Zelinski et al, 2013 , 2014b ; Deibel et al, 2019 ); 2L:19D ( Stephan, 1983 ); 9L:12D (current data, Craig and McDonald, 2008 ); 10.5L:10.5D ( Campuzano, 1998 ). When the failure to entrain occurs for a brief period of time before memory acquisition, memory consolidation is unaffected ( Craig and McDonald, 2008 ), but when it occurs during acquisition ( Devan et al, 2001 ), or in between acquisition and retention testing ( Zelinski et al, 2014b ; Lewis et al, 2020 ), consolidation is impacted.…”

Section: Resultsmentioning

confidence: 99%

“…The mechanisms for the memory impairments observed in our and other models that manipulate circadian rhythms are largely unknown ( Tapp and Holloway, 1981 ; Fekete et al, 1985 , 1986 ; Ruby et al, 2008 ; Gibson et al, 2010 ; Loh et al, 2010 , 2015 ; Fernandez et al, 2014 ; Lewis et al, 2020 ). As sleep is thought to be involved in memory consolidation ( Diekelmann and Born, 2010 ; Logothetis et al, 2012 ), and is controlled in part by circadian mechanisms ( Borbely and Tobler, 1985 ; Achermann and Borbely, 2003 ; Saper et al, 2005 ), its alteration has been discussed as a potential candidate ( Zelinski et al, 2014a ).…”

Section: Introductionmentioning

confidence: 95%

“…In rats, our lab studies the effect of light-dark cycles of a day length outside of the range of entrainment on learning and memory ( Devan et al, 2001 ; Craig and McDonald, 2008 ; McDonald et al, 2013 ; Zelinski et al, 2013 , 2014b ; Deibel et al, 2014 , 2019 ; Newman et al, 2019 ; Lewis et al, 2020 ). A light dark cycle in which the periodicity is anything other than 24 h is called a T cycle ( Stephan, 1983 ; Campuzano, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

et al. 2020

Self Cite

View full text Add to dashboard Cite

Circadian rhythm misalignment has a deleterious impact on the brain and the body. In rats, exposure to a 21-hour day length impairs hippocampal dependent memory. Sleep, and particularly K-complexes and sleep spindles in the cortex, have been hypothesized to be involved in memory consolidation. Altered K-complexes, sleep spindles, or interaction between the cortex and hippocampus could be a mechanism for the memory consolidation failure but has yet to be assessed in any circadian misalignment paradigm. In the current study, continuous local field potential recordings from five rats were used to assess the changes in aspects of behavior and sleep, including wheel running activity, quiet wakefulness, motionless sleep, slow wave sleep, REM sleep, K-complexes and sleep spindles, in rats exposed to six consecutive days of a T21 light-dark cycle (L9:D12). Except for a temporal redistribution of sleep and activity during the T21, there were no changes in period, or total amount for any aspect of sleep or activity. These data suggest that the memory impairment elicited from 6 days of T21 exposure is likely not due to changes in sleep architecture. It remains possible that hippocampal plasticity is affected by experiencing light when subjective circadian phase is calling for dark. However, if there is a reduction in hippocampal plasticity, changes in sleep appear not to be driving this effect.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning

Haraguchi

Nishimura

Fukuzawa

et al. 2020

Chronobiology International

View full text Add to dashboard Cite

Social Jetlag in adolescents: From a nursing perspective

Uslu

Özsaban

Çağan

2021

Child Adoles Psych Nursing

View full text Add to dashboard Cite

Problem Social Jetlag (SJL) is a condition leading to many important physical, mental, behavioral, and cognitive problems in adolescents. Methods The sample of this study, which used a descriptive and correlational design, consisted of 247 high school students. The SJL parameters were informed by the literature, while chronotype was identified using the Morningness‐Eveningness Scale for Children. The factors associated with SJL were determined using a structured questionnaire. Findings Students' SJL value was 2 h 10 min ± 01:11. As students' tendency to be an evening chronotype increased, the SJL value increased, as well (r = −0.472; p < 0.001). In terms of SJL, student's grade level (β = −0.167; p = 0.004) and chronotype (β = −0.438; p < 0.001) were a negative risk factor, while spending time in bed with TV/computer/smartphone before sleeping (β = 0.127; p = 0.031) was a positive risk factor. Conclusions The students had a high SJL value. The results might be useful for nurses to develop intervention strategies to improve adolescents sleep habits.

show abstract

Learning and memory in a rat model of social jetlag that also incorporates mealtime

Cited by 5 publications

References 58 publications

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

Assessment of Sleep, K-Complexes, and Sleep Spindles in a T21 Light-Dark Cycle

Use of a social jetlag-mimicking mouse model to determine the effects of a two-day delayed light- and/or feeding-shift on central and peripheral clock rhythms plus cognitive functioning

Social Jetlag in adolescents: From a nursing perspective

Contact Info

Product

Resources

About