Lean and Mean: Nanoparticle-Based Delivery Improves Performance of Cancer Drugs

Shekhar, Chandra

doi:10.1016/j.chembiol.2009.04.002

Cited by 10 publications

(11 citation statements)

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“…PLGA drug NP formulations are known to improve the therapeutic index in cancer and reduce morbidity and mortality. The localization and accumulation of drug loaded NPs within tumors as well as within cancer cells can significantly improve drug activity [48]. Our data showed that our PLGA-CUR NPs can efficiently internalize and maintain CUR levels in prostate cancer cells (Figure 1).…”

Section: Discussionmentioning

confidence: 82%

Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer

Yallapu¹,

Khan²,

Maher³

et al. 2014

Biomaterials

231

153

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Prostate cancer is the most commonly diagnosed cancer disease in men in the Unites States and its management remains challenge in everyday oncology practice. Thus, advanced therapeutic strategies are required to treat prostate cancer patients. Curcumin (CUR) is a promising anticancer agent for various cancer types. The objective of this study was to evaluate therapeutic potential of novel poly(lactic-co-glycolic acid)- CUR nanoparticles (PLGA-CUR NPs) for prostate cancer treatment. Our results indicate that PLGA-CUR NPs efficiently internalize in prostate cancer cells and release biologically active CUR in cytosolic compartment of cells for effective therapeutic activity. Cell proliferation (MTS), clonogenic, and Western blot analyses reveal that PLGA-CUR NPs can effectively inhibit proliferation and colony formation ability of prostate cancer cells than free CUR. PLGA-CUR NPs showed superior tumor regression compared to CUR in xenograft mice. Further investigations reveal that PLGA-CUR NPs inhibit nuclear β-catenin and AR expression in cells and in tumor xenograft tissues. It also suppresses STAT3 and AKT phosphorylation and leads to apoptosis via inhibition of key anti-apoptotic proteins, MCL-1, Bcl-xL and caused induction of PARP cleavage. Additionally, PLGA-CUR NPs significant downregulation of oncogenic miR21 and up-regulation of miR-205 was observed with PLGA-CUR NPs treatment as determined by RT-PCR and in situ hybridization analyses. A superior anti-cancer potential was attained with PSMA antibody conjugated PLGA-CUR NPs in prostate cancer cells and a significant tumor targeting of 131I labelled PSMA antibody was achieved with PLGA-CUR NPs in prostate cancer xenograft mice model. In conclusion, PLGA-CUR NPs can significantly accumulate and exhibit superior anticancer activity in prostate cancer.

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Section: Discussionmentioning

confidence: 82%

Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer

Yallapu¹,

Khan²,

Maher³

et al. 2014

Biomaterials

231

153

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“…The NP and NB showed high inhibition values in the growth of these cells, as the concentration of the formulations increased. This may be related to what has already been described in the literature, namely that the components of the nanoemulsion have antioxidant power and also to the size of the droplet, which facilitates absorption by tumor cells (SheKhAR, 2009). The presence of the nonionic surfactant, polysorbate 80, has also been indicated as a substance that can cause toxicity in cell cultures; although, they are better tolerated than ionic surfactants, especially cationic surfactants.…”

Section: Toxicity In Vitro Evaluationmentioning

confidence: 62%

Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion

et al. 2019

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Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage, it is observed that the nanoemulsion containing the extract had higher antitumor activity than the free extract. As for the in vivo tests, there was no change in the survival rate of the worms.

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“…In fact, many anti‐tumour drugs are accompanied by toxicity and side effects. Nanoparticle‐based delivery exploiting the enhanced permeability and retention (EPR) effect could solve these problems via enhancing the targeted delivery to the tumour . The commonly used nanocarriers for drug delivery in cancer include liposomes, nanoparticles and polymer micelles .…”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticle-based delivery exploiting the enhanced permeability and retention (EPR) effect could solve these problems via enhancing the targeted delivery to the tumour. [5] The commonly used nanocarriers for drug delivery in cancer include liposomes, nanoparticles and polymer micelles. [6] Among these nanomedicine platforms, liposomes are the most mature drug-delivery system with several formulations approved by the US Food and Drugs Administration (FDA).…”

Section: Introductionmentioning

confidence: 99%