Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats

Dimo, Théophile; Rakotonirina, S.V.; Tan, Paul V.; Azay, Jacqueline; Dongo, Étienne; Cros, Gérard

doi:10.1016/s0378-8741(02)00162-9

Cited by 75 publications

(64 citation statements)

References 37 publications

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“…It is 30-100 cm in height with yellow flowers and is well known as hairy beggar ticks, sticks tights, and Spanish needles. The plant is used in various folk medicines such as anti-inflammatory, antiseptic, liver-protective, blood-pressure lowering, and hypoglycemic effects (Dimo et al, 2002). Phenylpropanoid glucosides, polyacetylenes, a diterpenes, flavonoids, and flavone glycosides have been identified as bioactive components from this plant (Chiang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata

et al. 2008

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“…It is empirically used, as a decoction, for the treatment of various illnesses: in Cameroon for example, it is used for the management of hypertension (Dimo et al, 1999), in Taiwan for anti-oedemic and antiinflammatory activity (Duke, 1997). Difficult access to conventional drugs in low/middle income countries, like Cameroon, favours the use of medicinal plants for the management of cardiovascular diseases and oxidative stress and B. pilosa has been extensively studied for those properties (Dimo et al, 1999(Dimo et al, , 2002Chiang et al, 2004). In addition, the plant is used for curing many other diseases in and out of Cameroon (Dimo et al, 2002;Ezeonwumelu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic toxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) in male and female rats

Bopda¹,

Longo²,

Boade³

et al. 2016

J. Med. Plants Res.

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Bidens pilosa is used empirically for the treatment of various illnesses among which are: jaundice, conjunctivitis, cataract, malaria, ulcers and hypertension. This study is aimed at evaluating the subchronic toxicity of the leaf aqueous extracts of B. pilosa. The effects of the administration of the aqueous extracts of B. pilosa on physical (body weight, relative weight of organs), biochemical and histological parameters were studied in male and female albino Wistar rats. Daily doses of extract (100, 500 and 1000 mg/kg) and distilled water were administered orally for 4 weeks; during which signs of toxicity were checked. At the end of the experiments, the rats were sacrificed, their blood and organs collected for biochemical, histological and haematological analyses. No death was recorded. At the end of the treatment, there were no significant (P>0.05) variations of the body weight gain and the relative weights of detoxification organs (liver and kidney). The analysis of biochemical parameters showed a significant (p<0.001) variation of serum levels of ALT and creatinin. Histological analysis of liver and kidney, revealed no modification. The analysis of haematological parameters showed no significant difference between males and females, overall. However, when considering each sex in particular, it was observed that in males red blood cell distribution width-coefficient variation (RDWcv) significantly increased at the doses of 500 mg/kg (P=0.02) and 1000 mg/kg (P=0.04) (vs. control). Unlike in males, white blood cells (WBC) in females decreased significantly at 500 (P=0.01) and 1000 mg/kg (P=0.01) (vs. control). It can be concluded that Bidenspilosa has a relatively low toxic effects in both sexes, with some gender differences in the haematological results.

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“…Parts of the plant, form of the medicine and diseases treated in traditional medicine. Adeyemi et al, 2010;Adjanohoum et al, 1984;Adjanouhoun et al, 1996;Adzu et al, 2003;Agassounon et al 2008;Anete et al, 1998 ;Anuradha et al, 2008;Arbonnier, 2000;Berhaut, 1975;Brenan, 1959 ;Dimo et al, 2002;El-Mahmood et al, 2008;Ezugwu & Odoh, 2003;Gusman-Gutierez & Navarrete, 2009;Iwu, 1993;Joyner, 2004;Lompo et al, 1998;Malgras, 1992;Mutasa et al, 1990;Nazneen et al, 2009;Ogundiya, 2009;Ojewole, 2005;Palgrave, 2003;Pathak et al, 2010;Pousset, 1989;Satyarayana et al, 1996;Sunday et al, 2009;Saulnier, 1998;Seema Zareen, 2006;Worapan et al, 2009. with these plants, very few were done to study their sedative and anticonvulsant properties. This study was undertaken to evaluate the anticonvulsant and sedative properties of these plants used in the treatment of insomnia and epilepsy in traditional medicine in Africa, particularly in Cameroon.…”

Section: Introductionmentioning

confidence: 99%

Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Bum¹,

Taïwé²,

Moto³

et al. 2011

Clinical and Genetic Aspects of Epilepsy

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Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats

Cited by 75 publications

References 37 publications

Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata

Chemical composition and antioxidant, antibacterial and antifungal activities of the essential oils from Bidens pilosa Linn. var. Radiata

Sub-chronic toxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) in male and female rats

Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

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