Lead toxicity in cyanobacterial porphyrin metabolism

Zaccaro, M. C.; Salazar, Carmen; Caire, Gloria Zulpa de; Cano, Mónica Storni de; Stella, Ana María

doi:10.1002/1522-7278(2001)16:1<61::aid-tox70>3.0.co;2-l

Cited by 24 publications

(7 citation statements)

References 24 publications

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“…It has been reported that the METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 pathway is seriously affected in cadmium-exposed subjects [23,24]. The activity of MAPK SIGNALING pathway PORPHYRIN AND CHLOROPHYLL METABOLISM pathway have also been linked to environmental cadmium [25,26]. Again, the results provide evidence that that RIUT is a more powerful method than BIUT and this advantage transmitted to follow up interpretation analysis and considerably enhance power of microarray for biological findings.…”

Section: Detecting Genes That Have Persistent Response To Drug Treatmmentioning

confidence: 72%

Multiplicity Adjustment for Intersection-union Test: DetectingOverlapping Genes from Multiple Microarray Gene Lists

Deng¹,

Xu²,

Wang³

2007

Second International Multi-Symposiums on Computer and Computational Sciences (IMSCCS 2007)

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Detecting overlapping genes from multiple gene lists is a frequently used procedure in microarraybased studies. However in previous studies, the intersection operations of gene lists, formally known as the Intersection-Union Tests (IUTs), were performed without being aware of the incurred changes in Type 1 error rate. We presented an IUT adjustment procedure, called Relaxed IUT (RIUT), which is proved to be less conservative and more powerful for combining independent tests. We demonstrated the superiority of RIUT for detecting overlapping genes by simulation and two real toxicogenomic gene expression data sets. Notably, the better power of RIUT enables it to identify overlapping gene sets leading to known related pathways where traditional IUT fails to find. Second International Multisymposium on Computer and Computational Sciences0-7695-3039-7/07 $25.00

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Section: Detecting Genes That Have Persistent Response To Drug Treatmmentioning

confidence: 72%

Multiplicity Adjustment for Intersection-union Test: DetectingOverlapping Genes from Multiple Microarray Gene Lists

Deng¹,

Xu²,

Wang³

2007

Second International Multi-Symposiums on Computer and Computational Sciences (IMSCCS 2007)

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“…This result agrees with Khalil (1995) who showed that nickel exerts a stimulatory effect on protein accumulation in Phormidium fragile. Zaccaro et al (2001) working with Microchaete tenera also observed an increase in protein content as a response to lead.…”

Section: Statistical Methodologymentioning

confidence: 99%

Tolypothrix tenuis stress response to nickel

Storni

Zaccaro

Capano

et al. 2007

World J Microbiol Biotechnol

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Metal ions are both essential and potentially toxic. The aim of this work was to demonstrate that diazotrophic cyanobacterium Tolypothrix tenuis N°54 can tolerate toxic concentrations of Ni 2+ in order to use the biomass in biofilters or as biofertilizer. For this purpose, growth, pigment and protein contents and catalase activity of T. tenuis growing in increasing concentrations of Ni 2+ ranging from 10 )10 to 10 )4 M were assesed. The strain did not grow at Ni 2+ concentration of 10 )4 M, but at lower concentrations there were no significant differences with the control; it was tolerant at 10 )10 and 10 )8 M. Nickel concentration of 10 )6 M is toxic for this cyanobacterial strain, because dry weight decreased by 30%; allophycocyanin and phycoerythrin decreased by 92% and 98%, respectively and protein content increased by 42%. Chlorophyll a concentration was more than double the control value in 10 )10 and 10 )8 M, but in 10 )6 M it decreased by 19%. Catalase (E.C. 1.11.1.6) activity doubled the control value in the lowest nickel concentration whereas in 10 )8 M there was no significant difference with the control and in 10 )6 , it decreased by 78%. The living biomass of this strain could be used as a step in the bioremediation process in waters contaminated with concentrations of nickel lower than 10 )6 M and eventually as a biofertilizer.

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“…Zaccaro et al 73 documented that, the algal biofertilizers were likely to assume greater significance as complement and/or supplement to chemical fertilizers in improving the nutrient supplies to cereal crops because of high nutrient turn-over in the cereal production system, exorbitant cost of fertilizers and greater consciousness on environmental protection. Cytotoxicity activity.…”

mentioning

confidence: 90%