Lead poisoning with encephalic and neuropathic involvement in a child: case report

Rouzi, Latifa; Elhamri, Hecham; Kalouch, Samira; Salam, S.; Moutawakil, Bouchra El; Chaoui, Hanan; Badrane, Narjis; Fekhaoui, Mohammed; Jouhadi, Z.

doi:10.11604/pamj.2022.42.276.33007

Cited by 10 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a case study from Africa, a 3-year-old girl diagnosed with lead encephalopathy had a history of pica, and consumption of herbal medications. 5 In the authors' case, the 14-month-old boy resides in New Delhi, where his father is employed at a local paint factory, utilizing lead in its paint manufacturing process. The father frequently brought home painted toys from the factory for the child to play with and observed on numerous occasions the child chewed on these toys.…”

Section: Discussionmentioning

confidence: 99%

Neurological Presentation of Lead Toxicity: A Case Report

Gupta,

Kumar,

Gupta

2024

AMJ Neurology

View full text Add to dashboard Cite

Acute encephalopathy, caused by infectious agents, metabolic or mitochondrial dysfunction, brain tumor, or prolonged exposure to toxic elements, is a significant cause of morbidity and mortality in young children. Lead encephalopathy that occurs due to prolonged lead ingestion or exposure in children is not uncommon, and many such cases have been reported in the past. This report shares the authors’ experience of the missed diagnosis of lead encephalopathy, its red flags, and its relation to pica as a root cause. A 14-month-old boy, resident of Delhi, India, was admitted with vomiting, irritability, and two episodes of abnormal limb movements, with the first symptom starting when he was 11 months old. His case was initially treated as acute disseminated encephalomyelitis, but he showed no improvement. The child was then referred to the Sir Ganga Ram Hospital, New Delhi, India. The boy presented with severe anemia, along with basophilic stippling on the peripheral smear during routine investigations. Suspecting lead poisoning, blood lead levels were checked, and were found to be grossly elevated. The child was then started on chelation therapy. Multiple doses of chelation (dimercaprol and D-penicillamine) were given, and sequential blood lead levels were monitored, which showed a marked decrement. The child was discharged, and is being monitored routinely. Lead poisoning remains a neglected public health issue, especially in children, and delay in identification can cause significant morbidity and mortality. Pediatricians and general practitioners must be aware of this risk, especially in children with iron deficiency anemia exhibiting pica.

show abstract

Section: Discussionmentioning

confidence: 99%

Neurological Presentation of Lead Toxicity: A Case Report

Gupta,

Kumar,

Gupta

2024

AMJ Neurology

View full text Add to dashboard Cite

show abstract

“…Due to its ability to replace Zn and Ca in proteins, it has the ability to interfere with essential physiological processes [ 84 ]. The main effects of Pb exposure include neurological, respiratory, and cardiovascular disorders [ 85 , 86 ]. These are usually based on inflicting disturbances during immune modulation as well as oxidative and inflammatory mechanisms and are associated with a multitude of diseases [ 87 , 88 , 89 ].…”

Section: Non-essential/toxic Trace Elementsmentioning

confidence: 99%

The Role of Trace Elements in Cardiovascular Diseases

Wechselberger,

Messner,

Bernhard

2023

Toxics

View full text Add to dashboard Cite

Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.

show abstract

“…It was stated by the Centers for Disease Control and Prevention (USA) that lead concentrations below the level of concern are currently below 10 µg/dL. In contrast, very high levels are defined as above 70 µg/dL [3] and can result in encephalopathy, coma, or even death [4]. This highlights the need to elaborate novel methods for Pb 2+ ions detection characterized by high sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Aptasensor Miniaturization for Electrochemical Detection of Lead Ions

Jarczewska,

Sokal,

Olszewski

et al. 2024

Biosensors

View full text Add to dashboard Cite

Lead poses severe effects on living organisms, and since Pb2+ ions tend to accumulate in different organs, it is crucial to monitor Pb2+ concentration in samples such as water and soil. One of the approaches is the utilization of biosensors combined with aptamer-based layers for the electrochemical detection of lead ions. Herein, we present the studies of applying miniaturized screen-printed transducers as solid surfaces to fabricate aptamer layers. As the research is the direct continuation of our previous studies regarding the use of gold disk electrodes, the working parameters of elaborated aptasensors were defined, including the range of linear response (10–100 nM), selectivity as well as stability, regeneration, and feasibility of application for the analysis of real samples. This was achieved using voltammetric techniques including cyclic and square-wave voltammetry in the presence of methylene blue redox indicator.

show abstract

Lead poisoning with encephalic and neuropathic involvement in a child: case report

Cited by 10 publications

References 7 publications

Neurological Presentation of Lead Toxicity: A Case Report

Neurological Presentation of Lead Toxicity: A Case Report

The Role of Trace Elements in Cardiovascular Diseases

Studies on the Aptasensor Miniaturization for Electrochemical Detection of Lead Ions

Contact Info

Product

Resources

About