Lead Poisoning Due to Hai Ge Fen

Markowitz, Steven; Nunez, Carol M.; Klitzman, Susan; Munshi, Abdulrehman A.; Kim, Woo Sup; Eisinger, J.; Landrigan, Philip J.

doi:10.1001/jama.1994.03510360058037

Cited by 65 publications

(8 citation statements)

References 15 publications

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“…Alcohol consumption was significantly associated with increased blood lead levels in our data, and nonsignificant positive trends were evident for age and cigarette smoking. Use of herbal remedies has been previously linked to lead poisoning (Centers for Disease Control and Prevention 1993; Markowitz et al 1994). In the study by Muldoon et al (1994) of women 65–74 years of age, moderate physical activity was related to decreased blood lead values, but more strenuous activity was associated with increased lead levels.…”

Section: Discussionmentioning

confidence: 99%

Prospective Study of Blood and Tibia Lead in Women Undergoing Surgical Menopause

Berkowitz¹,

Wolff²,

Lapinski³

et al. 2004

Environ Health Perspect

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Despite the dramatic decline in environmental lead exposure in the United States during the past couple of decades, concern has been expressed regarding mobilization during menopause of existing lead stored in bone. To investigate whether bone lead concentrations decrease and blood lead levels increase, we conducted a prospective study of 91 women who were scheduled to undergo a bilateral oophorectomy for a benign condition at Mount Sinai Hospital in New York City during October 1994 through April 1999. We excluded women who were younger than 30 years of age or who were postmenopausal at the time of the surgery. We observed a small but significant increase in median blood lead levels between the baseline visit and the 6-month visit (0.4 μg/dL, p < 0.0001), particularly for women who were not on estrogen replacement therapy (0.7 μg/dL, p = 0.008). No significant change was observed in blood lead values between 6 and 18 months postsurgery, nor was there evidence of significant changes in tibia lead concentrations during the follow-up period. These findings do not point to substantial mobilization of lead from cortical bone during menopause.

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Section: Discussionmentioning

confidence: 99%

Prospective Study of Blood and Tibia Lead in Women Undergoing Surgical Menopause

Berkowitz¹,

Wolff²,

Lapinski³

et al. 2004

Environ Health Perspect

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“…It has been shown that traditional Asian and Indian remedies can be high in mercury, lead, and arsenic (Asian remedies) 5 or high levels of lead only (Indian remedies) 6 . Cases of poisoning attributable to toxic metals being present in medicinal plants have been reported in the USA, Europe, and Asia 7 – 10 . A toxicology unit based in London released a case series from 1991 to 1995 of adverse occurrences linked to traditional medicines 11 .…”

Section: Introductionmentioning

confidence: 99%

Heavy Metal contamination of Dietary Supplements products available in the UAE markets and the associated risk

Jairoun

Shahwan

Zyoud

2020

Sci Rep

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A specific safety concern is the possibility that a dietary supplement could be contaminated with heavy metals. This research was undertaken to investigate the daily exposure levels of heavy metals in dietary supplements available in the UAE and to explore the factors associated with the contamination of dietary supplements with heavy metals. A total of 277 dietary supplement samples were collected from the UAE market and prepared for the analysis of selected heavy metal contamination. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the presence of heavy metals. The average daily intake of cadmium was 0.73 μg [95% CI 0.61–0.85], compared to the acceptable daily intake (ADI) of 6 μg; the daily intake of lead was 0.85 μg [95% CI 0.62–1.07], compared to the acceptable daily intake (ADI) of 20 μg; and the daily intake of arsenic was 0.67 μg [95% CI 0.57–0.78], compared to the acceptable daily intake of 10 μg. Although the dietary supplements available in the UAE have low levels of heavy metal contamination, numerous individuals are consuming a number of different dietary supplements every day and thereby may experience a cumulative level of toxic exposure. Dietary supplements formulations (Categories), dosage forms and country of origin are strong determents of heavy metal contamination in dietary supplements products.

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“…The danger of herbal therapy is well recognized and may be attributable to adulteration with pharmaceuticals (17), to contamination with heavy metals (18), or to the inherent toxicity of the herb (19). THP causes profound myocardial suppression in animal cardiac structures such as the conduction system and myocardium.…”

Section: Discussionmentioning

confidence: 99%

Calcium Influx Inhibition: Possible Mechanism of the Negative Effect of Tetrahydropalmatine on Left Ventricular Pressure in Isolated Rat Heart

Chan¹,

Chiu²,

Chen³

et al. 1999

Planta med

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The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 microM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 microM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 microM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

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Lead Poisoning Due to Hai Ge Fen

Cited by 65 publications

References 15 publications

Prospective Study of Blood and Tibia Lead in Women Undergoing Surgical Menopause

Prospective Study of Blood and Tibia Lead in Women Undergoing Surgical Menopause

Heavy Metal contamination of Dietary Supplements products available in the UAE markets and the associated risk

Calcium Influx Inhibition: Possible Mechanism of the Negative Effect of Tetrahydropalmatine on Left Ventricular Pressure in Isolated Rat Heart

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