Lead Poisoning and Multiple Sclerosis

Westerman, Maxwell P.; Bruetman, Martin E.; Pfitzer, Emil A.

doi:10.1080/00039896.1974.10666615

Cited by 18 publications

(6 citation statements)

References 9 publications

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“…Hilderbrand et al (116) observed that sexually mature male rats exposed to lead acetate for 30 days exhibited impotence and prostatic hyperplasia at blood lead levels of [14][15][16][17][18][19][20][21][22][23][24][25][26] ,ug/100 ml, and testicular damage at blood lead levels of 50-100,g/100 ml. Similarly exposed female rats exhibited irregularities of the estrous cycle at blood lead levels of [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] ,Ag/100 ml and ovarian cysts at blood lead levels of 50-100 ,Lg/100 ml. Der et al (117) exposed 21-day old female rats daily to subcutaneous injections of lead acetate for 40 days.…”

Section: Effects On Reproductionmentioning

confidence: 99%

Toxicological properties of lead.

Damstra¹

1977

Environ Health Perspect

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The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead exposure. The crucial issue of whether subtle behavioral, intellectual, and developmental impairment occurs in young children, as a result of lead-induced CNS damage is discussed in detail. This issue remains unresolved. Further studies are needed in order to determine the long-term health effects of continuous, low-level lead exposure.

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Section: Effects On Reproductionmentioning

confidence: 99%

Toxicological properties of lead.

Damstra¹

1977

Environ Health Perspect

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“…Lead is not associated with the pathogenesis of multiple sclerosis5 6; however, lead poisoning can mimic many diseases. Our study indicates that lead poisoning is a possible differential diagnosis for exacerbation of the symptoms of multiple sclerosis, in particular the cerebellar and cognitive features.…”

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confidence: 99%

Lead poisoning from complementary and alternative medicine in multiple sclerosis

Fisher

Couteur²

2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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A patient with multiple sclerosis is described who was treated for neurological symptoms thought to be a progression of his disease but subsequently found to be caused by lead poisoning secondary to the use of alternative medicine. His clinical signs improved with oral chelation therapy. Neurologists should consider asking about the use of complementary and alternative medicine before simply attributing symptoms and signs to exacerbation of multiple sclerosis. (J Neurol Neurosurg Psychiatry 2000;69:687-689)

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“…hypertension (196,197), and a miscellany of diseases such as cancer (198), multiple sclerosis (199) and fetal malformations (200). At the end of his comprehensive summary of both child-and animal-based investigations, Rutter concludes that "the evidence considered as a whole is compatible with the suggestion that low level lead exposure might cause some form of biological impairment, but that is about as much that can be said" (209).…”

Section: Subclinical Lead Toxicitymentioning

confidence: 99%

Metabolism and Toxicology of Lead

Taylor

1986

Reviews on Environmental Health

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Metabolism and toxicology of leadAmong the metals which are described as biological trace elements, lead has attracted the greatest interest.In part, this is a reflection of the extensive use of the metal for industrial and related purposes over several thousands of years (1-3) and the well recognised symptoms of toxicity (4).In addition, concern has been increasing at the amount of "environmental lead" to which the population may be exposed.Environmental sources of lead include foods, paint pigments and lead in petrol and are discussed in greater detail below.Lead has not been demonstrated to be an essential trace element with symptoms of deficiency developing if inadequately supplied. Nevertheless, nutritional aspects of the metal have been recently studied following recognition that interactions with other dietary constituents can influence toxicity.With very few exceptions exposure is to metallic lead e.g. as the vapour or to inorganic lead salts. Tetra-ethyl and other organo lead compounds are exceedingly toxic, but it is unusual for persons not associated with their manufacture or their use in the petroleum industry to receive significant exposure.This review, therefore, will not include details of organolead toxicity.

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Lead Poisoning and Multiple Sclerosis

Cited by 18 publications

References 9 publications

Toxicological properties of lead.

Toxicological properties of lead.

Lead poisoning from complementary and alternative medicine in multiple sclerosis

Metabolism and Toxicology of Lead

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